86,537 research outputs found
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
EPIDERMIS AND HAIR FOLLICLE IN BOVINE SKIN EXPRESS THE LEPTIN HORMONE AND ITS RECEPTOR
No full textLeptin (Ob) is a hormone that acts through the activation of the specific receptor Ob-R. It is mainly secreted by visceral and subcutaneous adipose tissue and represents the first known adipokine [1]. Ob is a pleiotropic molecule and plays an important role in the skin, where it stimulates keratinocytes to proliferate and intervenes in the regulation of wound healing processes. It also participates in the control of hair follicle morphogenesis and its cycles of growth, regression, and rest [2]. Ob may act through endocrine, paracrine and autocrine mechanisms. While it is secreted by skin structures including epidermis and hair follicles, intradermal adipose tissue also seems to have a role in Ob secretion and accordingly in the control of the hair follicle cycle in mice and humans [3]. In this work, the morphological characteristics of the skin in bovine species were evaluated by Hematoxylin-Eosin and Oil Red O stainings to investigate the presence and extension of intradermal adipose tissue that may be invoved in Ob secretion. Moreover, Ob and Ob-R expression were analized by means of RT-PCR and immunohistochemistry. Through the morphological analysis, a high and thick dermis without adipocytes was observed. Hair follicles and glands were located in the prossimal part of the skin, beneath the epidermis, while a thick layer of connective tissue, lacking adipose cells, separated these structures by subcutis. RT-PCR gave a positive outcome, evidencing the transcripts for both molecules in the bovine skin samples examined By immunohistochemistry, Ob and its receptor were observed in the epidermis and in the outer root sheath of hair follicles during the follicular cycle. The epidermis abundantly expressed Ob; while all layers of cells were involved, the suprabasal layers expressed a stronger signal. Ob-R was observed in the cells of the basal layer. As regards hair follicles, both Ob and Ob-R were expressed by the outer root sheath of hair follicles. Staining mainly extended into the regions of the infundibulum and isthmus while the bulb was negative. Immunostaining persisted in all stages of hair follicles. The expression of Ob-R in the bovine skin proves that Ob acts on this peripheral organ. The identification of Ob in the epidermis and hair follicle epithelium attests that Ob may act through a paracrine and autocrine mechanism on these structures even if an endocrine mechanism cannot be excluded. The absence of adipocytes around hair follicles and, broadly, in all the dermis indicates that the intradermal adipose tissue does not exist in bovine and accordingly cannot exert paracrine control on the hair follicle. The identification of the Ob system in bovine skin provides important information for properly understanding the biological mechanisms that regulate skin structures, and well as for comparing animal species and highlighting their differences
Diversità delle comunità macrobentoniche e qualità ambientale delle sorgenti dei Monti della Laga (Parco Nazionale Gran Sasso – Laga, Appennino centrale)
No full text[Newspaper Clipping: Author Claims Evidence of Second JFK Assassin #1]
No full textNewspaper article titled "Author Claims Evidence of Second JFK Assassin." The article states that author Richard J. Whalen concluded "that there is circumstantial evidence to support the theory of a second assassin in the shooting of President John F. Kennedy.
Path planning for underwater information gathering based on genetic algorithms and data stochastic models
No full textRecent technological developments have paved the way to the employment of Autonomous Underwater Vehicles (AUVs) for monitoring and exploration activities of marine environments. Traditionally, in information gathering scenarios for monitoring purposes, AUVs follow predefined paths that are not efficient in terms of information content and energy consumption. Informative Path Planning (IPP) represents a valid alternative, defining the path that maximises the gathered information. This work proposes a Genetic Path Planner (GPP), which consists in an IPP strategy based on a Genetic Algorithm, with the aim of generating a path that simultaneously maximises the information gathered and the coverage of the inspected area. The proposed approach has been tested offline for monitoring and inspection applications of Posidonia Oceanica (PO) in three different geographical areas. The a priori knowledge about the presence of PO, in probabilistic terms, has been modelled utilising a Gaussian Process (GP), trained on real marine data. The GP estimate has then been exploited to retrieve an information content of each position in the areas of interest. A comparison with other two IPP approaches has been carried out to assess the performance of the proposed algorithm
Also By The Same Author: AKTiveAuthor, a Citation Graph Approach to Name Disambiguation
No full textThe desire for definitive data and the semantic web drive for inference over heterogeneous data sources requires co-reference resolution to be performed on those data. In particular, name disambiguation is required to allow accurate publication lists, citation counts and impact measures to be determined. This paper describes a graph-based approach to author disambiguation on large-scale citation networks. Using self-citation, co-authorship and document source analyses, AKTiveAuthor clusters papers, achieving precision of 0.997 and recall of 0.818 over a test group of eight surname clusters
John F. Kennedy telegram to Roosevelt
No full textJersey Homesteads (later the Borough of Roosevelt) was established in the 1930s as an agro-industrial cooperative community. It was established specifically for urban Jewish garment workers, many of whom had emigrated from Europe. President John F. Kennedy sent a telegram to the citizens of Roosevelt, New Jersey, apologizing for not being able to attend the memorial dedication in honor of former President Franklin Delano Roosevelt. (Jersey Homesteads became Roosevelt in 1945 in honor of the president.) President Kennedy expressed his gratitude to the people of Roosevelt for constructing the memorial, and commented that it will serve as a constant reminder of Roosevelt's good works
Extracellular vesicles from triple negative breast cancer promote pro-inflammatory macrophages associated with better clinical outcome
No full textTumor associated macrophages (TAMs), which differentiate from circulating monocytes, are pervasive across human cancers and comprise heterogeneous populations. The contribution of tumor-derived signals to TAM heterogeneity is not well understood. In particular, tumors release both soluble factors and extracellular vesicles (EVs), whose respective impact on TAM precursors may be different. Here, we show that triple negative breast cancer cells (TNBCs) release EVs and soluble molecules promoting monocyte differentiation toward distinct macrophage fates. EVs specifically promoted proinflammatory macrophages bearing an interferon response signature. The combination in TNBC EVs of surface CSF-1 promoting survival and cargoes promoting cGAS/STING or other activation pathways led to differentiation of this particular macrophage subset. Notably, macrophages expressing the EV-induced signature were found among patients’ TAMs. Furthermore, higher expression of this signature was associated with T cell infiltration and extended patient survival. Together, this data indicates that TNBC-released CSF-1-bearing EVs promote a tumor immune microenvironment associated with a better prognosis in TNBC patients
Logarithmic variance profiles and the corresponding f-1 spectra of temperature fluctuations in turbulent Rayleigh-Bénard convection
No full textWe report experimental results for the temperature variance 2(z) and the corresponding frequency spectra P(f) in turbulent Rayleigh-Bénard convection (RBC) in a cylindrical sample of aspect ratioT= D/L = 1:00 (D = 1:12 m is the diameter and L = 1:12 m the height). The measurements were conducted in the Rayleigh-number range 1011 < Ra < 1:35 1014 and Pr ' 0:8. For Ra = 1:35x1014, 2(z) could be described well by a logarithmic dependence on the vertical position z in a range of z 1 < z < z 2 with z 1 ' 70 and z 2 = 0:1L. Here L=(2Nu) is the thickness of a thin thermal sublayer adjacent to the horizontal plate where the heat flux (denoted by the Nusselt number Nu) is carried mostly by thermal diffusion. In the log layer, we found that the temperature spectra had a significant frequency range over which P(f) f with close to 1. As Ra decreased, increased so that the log layer became thinner. At Ra = 2:05 1011, z 2 < z 1 and therefore there was no range for a log layer. Correspondingly, the temperature spectrum near the horizontal plate did not have the f1 scaling form either
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