1,720,971 research outputs found
Overview of physiological processes during sleep
No full textPhysiological regulation can be defined as the integrated neural control mechanism underlying somatic, autonomic, and neuroendocrine activity. Such an integration occurs mostly at hypothalamic level. Physiological regulation is intrinsically heterogeneous between non-rapid eye movement (NREM) and rapid eye movement (REM) sleep. During NREM sleep, it is aimed at the maintenance of body homeostasis at a low level of energy expenditure. During REM sleep, the cardiorespiratory instability and the thermoregulatory impairment are indicative of a derangement of the integrative neural regulation of physiological functions. However, the finding that osmoregulation is maintained during REMS suggests that this derangement does not affect the whole hypothalamus
Overview of physiological processes during sleep
No full textPhysiological regulation can be defined as the integrated neural control mechanism underlying somatic, autonomic, and neuroendocrine activity. Such an integration occurs mostly at hypothalamic level. Physiological regulation is intrinsically heterogeneous between non-rapid eye movement (NREM) and rapid eye movement (REM) sleep. During NREM sleep, it is aimed at the maintenance of body homeostasis at a low level of energy expenditure. During REM sleep, the cardiorespiratory instability and the thermoregulatory impairment are indicative of a derangement of the integrative neural regulation of physiological functions. However, the finding that osmoregulation is maintained during REMS suggests that this derangement does not affect the whole hypothalamus
Sleep deprivation soon after recovery from synthetic torpor enhances tau protein dephosphorylation in the rat brain
Full text linkNeuronal Tau protein hyperphosphorylation (PPtau) is a hallmark of tauopathic neurodegeneration. However, a reversible brain PPtau occurs in mammals during either natural or "synthetic" torpor (ST), a transient deep hypothermic state that can be pharmacologically induced in rats. Since in both conditions a high sleep pressure builds up during the regaining of euthermia, the aim of this work was to assess the possible role of post-ST sleep in PPtau dephosphorylation. Male rats were studied at the hypothermic nadir of ST, and 3-6 h after the recovery of euthermia, after either normal sleep (NS) or total sleep deprivation (SD). The effects of SD were studied by assessing: (i) deep brain temperature (Tb); (ii) immunofluorescent staining for AT8 (phosphorylated Tau) and Tau-1 (non-phosphorylated Tau), assessed in 19 brain structures; (iii) different phosphorylated forms of Tau and the main cellular factors involved in Tau phospho-regulation, including pro- and anti-apoptotic markers, assessed through western blot in the parietal cortex and hippocampus; (iv) systemic factors which are involved in natural torpor; (v) microglia activation state, by considering morphometric variations. Unexpectedly, the reversibility of PPtau was more efficient in SD than in NS animals, and was concomitant with a higher Tb, higher melatonin plasma levels, and a higher frequency of the microglia resting phenotype. Since the reversibility of ST-induced PPtau was previously shown to be driven by a latent physiological molecular mechanism triggered by deep hypothermia, short-term SD soon after the regaining of euthermia seems to boost the possible neuroprotective effects of this mechanism
c-Fos expression in the anterior and mediodorsal thalamus following cold exposure in the rat.
No full textAuthor Correction: Neural control of fasting-induced torpor in mice (Scientific Reports, (2019), 9, 1, (15462), 10.1038/s41598-019-51841-2)
No full textIn this Article, there is a repeated typographical error in the legends of Figure 1, 2 and 3 where, “§p ̧ 0.05 vs. Fasting group; #p ̧ 0.05 vs. all other conditions.” should read: “#p ̧ 0.05 vs. Fasting group; §p 0.05 vs. all other conditions.”
Involvement of serotonergic neurons in thermogenic and wake-promoting effects of orexin-A delivery into the raphe pallidus in the rat.
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
- …
