39,808 research outputs found
Link stability estimation based on link connectivity changes in mobile ad-hoc networks
No full textDear Wang,
Re: Link Stability Estimation Based on Link Connectivity Changes in Mobile Ad-hoc Networks
I have not been able to assess if this is an author version peer-reviewed or is it an author version non peer reviewed. Could you please clarify this so I can proceed to add your paper to Spiral. Spiral digital repository only accept peer-reviewed papers.
30/11/12 author has confirmed peer reviewe
Tim Foster\u27s Regenerative Craft Website
No full textThis portfolio website explains and contextualizes Tim Foster\u27s Fairhaven Interdisciplinary concentration in Regenerative Design, Ecological Solutions and Craft through design and writing. Website link: https://timfoster.webflow.io
Preserving Linked Data Integrity on the Semantic Web by application of techniques from Hypermedia
No full textThis report presents a Literature Review of past work in Hypertext link integrity and current work in the emerging area of Semantic Web link integrity. A design and prototype for a system which applies some ideas from Hypertext link integrity to the Semantic Web is presented alongside plans for future enhancements of this system. In addition other possible avenues of research regarding ideas from traditional Hypertext link integrity are briefly discussed
Citebase Search: Autonomous Citation Database for e-Print Archives
No full textCitebase is a culmination of the Opcit Project and the Open Archives Initiative. The Opcit Project's aim to citation-link arXiv.org was coupled with the interoperability of the OAI to develop a cross-archive search engine with the ability to harvest, parse, and link research paper bibliographies. These citation links create a classic citation database which is used to generate citation analysis and navigation over the e-print literature. Citebase is now linked from arXiv.org, alongside SLAC/SPIRES, and is integrated with e-Prints.org repositories using Paracite
Pairwise stable networks in homogeneous societies with weak link externalities
No full textWe study general properties of pairwise stable and pairwise Nash stable networks when players are ex-ante homogeneous. Rather than assuming a particular functional form of utility, we impose general link externality conditions on utility such as ordinal convexity and ordinal strategic complements. Depending on these rather weak notions of link externalities, we show that pairwise Nash stable networks of various structure exist. For stronger versions of the convexity and strategic complements conditions, we are even able to characterize all pairwise stable networks: they are nested split graphs. We illustrate these results with many examples from the literature, including utility functions that arise from games with strategic complements played on the network and utility functions that depend on centrality measures such as Bonacich centrality
An initial exploration of the link relationship between UK university Web sites.
No full textAggregates of links are of interest to information scientists in the same way as citation counts are: as potential sources of data from which new knowledge can be mined. Builds on the recent discovery of a correlation between a Web link count measure and the research quality of British universities by applying a range of multivariate statistical techniques to counts of links between pairs of universities. This represents an initial attempt at developing an understanding of this phenomenon. Extracts plausible results. Also identifies outliers in the data by the techniques, some of which were verified by being tracked down to identifiable Web phenomena. This is an important outcome because successful anomaly identification is a precondition to more effective analysis of this kind of data. The identification of groupings is encouraging evidence that Web links between universities can be mined for significant results, although it is clear that more methodological development is needed, if any but the simplest patterns are to be extracted. Finally, based upon the types of patterns extracted, argues that none of the methods used are capable of fully analysing link structures on their own
Child Protection and Educational Neglect: A Preliminary Study (ML Special Issue #1)
No full textMinn-LInK is a unique collaborative, university-based research environment with the express purpose of studying child and family well being in Minnesota using state administrative data from multiple agencies.The purpose of this study is to begin the exploration of child protection intervention into educational neglect in the State of Minnesota.Zuel, Tim; Larson, Anita. (2005). Child Protection and Educational Neglect: A Preliminary Study (ML Special Issue #1). Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/185498
Biochemical and biophysical characterization of the human TIM/TIPIN/CRY complex - a potential direct link between the circadian clock and the cell cycle
No full textThe circadian clock controls the behavior of many lifeforms and is functionally connected to
DNA replication and DNA damage response. Central circadian regulators influence cell cycle
and DNA damage response by altering protein expression of regulatory factors or by interacting
with them. The central circadian repressor CRY interacts with the TIM/TIPIN complex, that is
involved in signaling of stalled replication forks and DNA damage. CRY affects TIMs’ ability
to activate the CHK1 kinase which in turn leads to activation of cell cycle checkpoints and
repair of DNA damage. It is not clear how the interaction is achieved, whether there is a direct
interaction of both proteins or if they are parts of a larger complex.
With purified proteins we showed that CRY bound TIM/TIPIN in a direct manner and formed
a stoichiometric trimeric complex. We found that the two human CRY paralogs (CRY1 and
CRY2) differ in their affinity to TTP and that CRY2 bound with higher affinity. This was
possibly due to the highly variable tails between CRY1 and CRY2 as most divergent feature
between CRY1 and CRY2. We furthermore confirmed data from literature, that the TIM NTerminus
is sufficient to bind CRY. A functionally undescribed loop within TIM was
dispensable for CRY binding, but caused both CRYs to bind with different affinities, indicating
a further regulatory detail. Using Small-Angle X-Ray scattering and Crosslink MS, we created
a hypothetical model to visualize the interaction of CRY and TIM. Initial pulldown experiments
identified candidate proteins that might be affected by the TIM loop.
The observation of a direct trimeric complex of TTP/CRY indicates that CRY and TIM/TIPIN
functionally connect the circadian clock with signaling of DNA damage and replication stress.
Different binding affinities of CRY1 and CRY2 to TTP give a hint in order to understand
functional differences between the CRY paralogs and indicate functional importance of the Cterminal
CRY tails. The TIM loop was not functionally described before and its effect on CRY
binding could indicate an additional regulatory detail. The candidate proteins identified in a
TIM loop dependent pulldown could serve as a starting point for functional characterization of
the TIM loop.Die innere Uhr beeinflusst das Verhalten vieler Lebensformen und ist funktionell verbunden
mit der DNA Replikation und der zellulären Reaktion auf DNA Schäden. Circadiane
Regulatoren können auf diese Prozesse Einfluss nehmen, indem sie die Biosynthese von daran
beteiligten Proteinen steuern oder direkt mit diesen interagieren. Der zentrale circadiane
Repressor CRY interagiert mit dem TIM/TIPIN Komplex, der in die Signaltransduktion von
stockenden Replikationsgabeln und DNA Schäden involviert ist. CRY kann TIMs Fähigkeit,
die CHK1 Kinase zu aktivieren, beeinflussen. Nach Aktivierung der CHK1 Kinase, aktiviert
CHK1 Prozesse wie den Zellzyklusarrest in der S-Phase und DNA Reparatur. Es ist unklar, wie
die Interaktion von CRY und TIM/TIPIN reguliert ist und ob es sich um eine direkte Interaktion
handelt oder ob sie Teile eines gemeinsamen großen Komplexes sind.
Mit isolierten Proteinen konnten wir zeigen, dass CRY TIM/TIPIN direkt band und einen
trimeren Komplex bildete. Wir haben beobachtet, dass sich die beiden CRY Paraloge (CRY1
und CRY2) in ihrer Affinität zu TIM/TIPIN unterschieden und dass CRY2 mit einer höheren
Affinität band. Dieser Effekt war möglicherweise auf die flexiblen C-terminalen Anhänge von
CRY zurückzuführen, die sich zwischen CRY1 und CRY2 stark unterscheiden. Wir vermuten,
dass dieser Unterschied auf unterschiedliche Interaktionen des CRY Anhangs mit einer bisher
funktionell unbeschriebenen Proteinschleife von TIM zurückzuführen ist. Diese Proteinschleife
war für die Bindung an CRY nicht essentiell und ihre Deletion verursachte, dass die CRY
Proteine TIM/TIPIN mit gleicher Affinität banden. Mit Hilfe von Small-Angle X-Ray Scattering
und Crosslink Massenspektrometrie Daten erstellten wir ein hypothetisches Modell für einen
CRY/TIM Komplex. Initiale Pulldown Experimente konnten Kandidatenproteine
identifizieren, welche durch die TIM Proteinschlaufe beeinflusst werden könnten.
Die Beobachtung des direkten trimeren Komplexes zwischen CRY und TIM/TIPIN deutet an,
dass diese Proteine eine direkte Verbindung zwischen der inneren Uhr und der zellulären
Reaktion auf DNA Schäden und Replikationsstress darstellen. Unterschiedliche
Bindungsaffinitäten zwischen den CRY Paralogen und TIM/TIPIN lassen funktionelle
Unterschiede vermuten und geben einen Hinweis auf die funktionelle Bedeutung der Cterminalen
CRY Anhänge. Die TIM Proteinschleife wurde bisher nicht funktionell beschrieben,
und ihr Effekt auf die CRY Bindung könnte ein weiteres regulatorisches Detail darstellen. Die
im Pulldown identifizierten Kandidatenproteine könnten als Ausgangspunkt für eine weitere
funktionelle Charakterisierung der TIM Proteinschlaufe dienen.XII, 182 Blätte
Player agency in interactive narrative: audience, actor & author
No full textThe question motivating this review paper is, how can
computer-based interactive narrative be used as a constructivist learn-
ing activity? The paper proposes that player agency can be used to
link interactive narrative to learner agency in constructivist theory,
and to classify approaches to interactive narrative. The traditional
question driving research in interactive narrative is, ‘how can an in-
teractive narrative deal with a high degree of player agency, while
maintaining a coherent and well-formed narrative?’ This question
derives from an Aristotelian approach to interactive narrative that,
as the question shows, is inherently antagonistic to player agency.
Within this approach, player agency must be restricted and manip-
ulated to maintain the narrative. Two alternative approaches based
on Brecht’s Epic Theatre and Boal’s Theatre of the Oppressed are
reviewed. If a Boalian approach to interactive narrative is taken the
conflict between narrative and player agency dissolves. The question
that emerges from this approach is quite different from the traditional
question above, and presents a more useful approach to applying in-
teractive narrative as a constructivist learning activity
Governing Minnesota: Tim Walz on the past year and the road ahead
No full textJoin us for a conversation with Governor Tim Walz as he begins his second year in office. Gov. Walz will reflect on the progress and challenges he has experienced with his agenda so far, as well as lay out his 2020 legislative session priorities for the state. WCCO political reporter Pat Kessler will moderate the conversation.
This event will also be live streamed on our YouTube page. Streaming at the link z.umn.edu/Walzlive will begin shortly before the event. Guests will be seated on a first-come, first served basis. Please be sure to arrive early to secure a seat.
Tim Walz is the 41st Governor of Minnesota, elected in 2018. Walz served six terms in the U.S. House of Representatives serving Minnesota's First Congressional District. In Congress, Walz served on the Agriculture Committee, Armed Services Committee and Veterans' Affairs Committee. Walz also served on the Congressional-Executive Commission on China. Before his election to Congress, Walz spent 24 years in the Army National Guard and was a teacher and coach at Mankato West High School.
Pat Kessler has been covering Minnesota politics for more than 30 years. In 2015, he was honored for lifetime achievement in broadcasting by the Midwest chapter of the National Academy of Television Arts and Sciences. Before joining WCCO-TV, Mr. Kessler was a reporter for Minnesota Public Radio and a technical assistant for “A Prairie Home Companion.”Walz, Tim; Kessler, Pat. (2020). Governing Minnesota: Tim Walz on the past year and the road ahead. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/214901
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