11,226 research outputs found
Connecting Research with Communities through Performative Social Science
No full textA pioneer in Performative Social Science, Kip Jones makes a case for the potential of arts-based social science to reach audiences and engage communities. Jones contextualises both the use of the arts in Social Science, as well as the utility of Social Science in the Arts and Humanities. The discussion turns next to examples from his own work and what happens when Art talks to Social Science and Social Science responds to Art. The benefits of such interaction and interdisciplinarity are outlined in relation to a recently completed project using multi-methods, which resulted in the production of a professional short film. In conclusion, Performative Social Science is redefined in terms of synthesis that can break down old boundaries, open up channels of communication and empower communities through engagement
Theoretical frameworks for the learning of geometrical reasoning
No full textWith the growth in interest in geometrical ideas it is important to be clear about the nature of geometrical reasoning and how it develops. This paper provides an overview of three theoretical frameworks for the learning of geometrical reasoning: the van Hiele model of thinking in geometry, Fischbein’s theory of figural concepts, and Duval’s cognitive model of geometrical reasoning. Each of these frameworks provides theoretical resources to support research into the development of geometrical reasoning in students and related aspects of visualisation and construction. This overview concludes that much research about the deep process of the development and the learning of visualisation and reasoning is still needed
Upregulation of the Tim-3/galectin-9 pathway of T cell exhaustion in chronic hepatitis B virus infection.
No full textThe S-type lectin galectin-9 binds to the negative regulatory molecule Tim-3 on T cells and induces their apoptotic deletion or functional inactivation. We investigated whether galectin-9/Tim-3 interactions contribute to the deletion and exhaustion of the antiviral T cell response in chronic hepatitis B virus infection (CHB). We found Tim-3 to be expressed on a higher percentage of CD4 and CD8 T cells from patients with CHB than healthy controls (p<0.0001) and to be enriched on activated T cells and those infiltrating the HBV-infected liver. Direct ex vivo examination of virus-specific CD8 T cells binding HLA-A2/peptide multimers revealed that Tim-3 was more highly upregulated on HBV-specific CD8 T cells than CMV-specific CD8 T cells or the global CD8 T cell population in patients with CHB (p<0.001) or than on HBV-specific CD8 after resolution of infection. T cells expressing Tim-3 had an impaired ability to produce IFN-γ and TNF-α upon recognition of HBV-peptides and were susceptible to galectin-9-triggered cell death in vitro. Galectin-9 was detectable at increased concentrations in the sera of patients with active CHB-related liver inflammation (p = 0.02) and was strongly expressed by Kupffer cells within the liver sinusoidal network. Tim-3 blockade resulted in enhanced expansion of HBV-specific CD8 T cells able to produce cytokines and mediate cytotoxicity in vitro. Blocking PD-1 in combination with Tim-3 enhanced the number of patients from whom functional antiviral responses could be recovered and/or the strength of responses, indicating that these co-inhibitory molecules play a non-redundant role in driving T cell exhaustion in CHB. Patients taking antivirals able to potently suppress HBV viraemia continued to express Tim-3 on their T cells and respond to Tim-3 blockade. In summary, both Tim-3 and galectin-9 are increased in CHB and may contribute to the inhibition and deletion of T cells as they infiltrate the HBV-infected liver
The shaping of student knowledge: learning with dynamic geometry software
No full textThe focus of this paper is a software genre usually referred to as ‘dynamic geometry’ because of the ability of the user to dynamically manipulate geometrical figures created with the software tool. Using data from a longitudinal study of 12-13 students’ use of dynamic geometry software, the focus of the analysis is on the interpretations the students make of geometrical objects and relationships when using this form of software. The analysis suggests that the students’ mathematical reasoning is shaped by their interactions with the software in that their ability to explain geometrical facts and relationships evolves from imprecise, ‘everyday’ expressions, through reasoning that is overtly mediated by the software environment, to mathematical explanations of the geometric situation that transcend the particular tool being used. Such findings suggest that curriculum initiatives that encourage the use of dynamic geometry software are appropriate but that the incorporation of such software into classroom practices is unlikely to be straightforward
Reaction of 3-chloro-3-methyldiazirines with hydrogen atoms
No full textPT: J; CR: BINGHAM RC, 1975, J AM CHEM SOC, V97, P1285 BRADLEY GF, 1977, J CHEM SOC P2, P1214 BRASLAVSKY S, 1977, CHEM REV, V77, P473 CHADWELL HM, 1933, J AM CHEM SOC, V55, P1363 CLARK DT, 1969, T FARADAY SOC, V62, P393 CLARK DT, 1969, T FARADAY SOC, V62, P399 CLARK DT, 1969, T FARADAY SOC, V62, P405 CLOUGH PN, 1970, CAN J CHEM, V48, P2919 DYKSTRA CE, 1978, J AM CHEM SOC, V100, P1378 FIGUERA JM, 1978, J CHEM SOC F1, P809 FREY HM, 1966, ADV PHOTOCHEM, V4, P225 FREY HM, 1977, J CHEM SOC F1, P2010 GILBERT JC, 1979, TETRAHEDRON LETT, P4619 GRAHAM WH, 1965, J AM CHEM SOC, V87, P4306 JAMIESON JWS, 1970, CAN J CHEM, V48, P3619 JENNINGS BM, 1976, J AM CHEM SOC, V98, P6416 JONES M, 1973, CARBENES, V1 JONES WE, CHEM BIOMED ENV INST JONES WE, 1973, CHEM REV, V73, P407 JONES WE, 1978, J CHEM SOC F2, V74, P831 LAU A, 1964, SPECTROCHIM ACTA, V20, P97 LIU MTH, UNPUBLISHED LIU MTH, 1973, CAN J CHEM, V51, P2393 LIU MTH, 1977, CAN J CHEM, V55, P3596 MAEDA Y, 1979, J AM CHEM SOC, V101, P837 MARTIN LR, 1979, INT J CHEM KINET, V11, P543 MEIER H, 1977, ANGEW CHEM INT EDIT, V16, P835 MOFFAT JB, 1978, CHEM DIAZONIUM DIA 1 MOSS RA, 1978, J CHEM SOC CHEM COMM, P775 SCHMITZ E, 1964, ANGEW CHEM INT EDIT, V3, P333 SCHMITZ E, 1971, 23RD INT C PUR ALL C, V2, P283 SCOTT PM, 1969, J PHYS CHEM-US, V73, P1513 SMITH NP, 1979, J CHEM SOC P2, P213 WITTER RA, 1973, J ORG CHEM, V38, P484; NR: 34; TC: 3; J9: J AMER CHEM SOC; PG: 2; GA: JN379Source type: Electronic(1
MNDO calculations on diazirines
No full textPT: J; CR: ARCHER WH, 1976, J CHEM SOC F1, V72, P1448 BIGOT B, 1978, IUPAC S PHOTOCHEMIST, P46 BINKLEY JS, QPCE368 BRADLEY GF, 1977, J CHEM SOC P2, P1214 BRASLAVSKY S, 1977, CHEM REV, V77, P473 BURKHOLDER D, J AM CHEM SOC CLOUGH PN, 1970, CAN J CHEM, V48, P2919 DEWAR MJS, J AM CHEM SOC, V99, P4999 DEWAR MJS, 1977, J AM CHEM SOC, V99, P4907 DEWAR MJS, 1978, J AM CHEM SOC, V100, P3607 DEWAR MJS, 1978, J AM CHEM SOC, V100, P777 ENGLEBRECHT WJ, 1975, JS AFRICAN CHEM I, V28, P191 FIGUERA JM, 1978, J CHEM SOC F1, P809 FREY HM, 1966, ADV PHOTOCHEM, V4, P225 FREY HM, 1977, J CHEM SOC F1, P2010 GILBERT JC, 1979, TETRAHEDRON LETT, P4619 HEHRE WJ, 1972, J CHEM PHYS, V56, P2257 HENCHER JL, 1967, J AM CHEM SOC, V89, P5527 JENNINGS BM, 1976, J AM CHEM SOC, V98, P6416 JONES M, 1973, CARBENES, V1 JONES WE, 1973, CHEM REV, V73, P407 JONES WE, 1976, J PHOTOCHEM, V5, P311 JONES WE, 1978, J CHEM SOC F2, V74, P831 LATHAN WA, 1973, FORTSCHR CHEM FORSCH, V40, P1 LAU A, 1964, SPECTROCHIM ACTA, V20, P97 LIU MTH, 1973, CAN J CHEM, V51, P2393 LIU MTH, 1977, CAN J CHEM, V55, P3596 MARTIN M, 1976, REV ROUM CHIM, V21, P31 MEIER H, 1977, ANGEW CHEM INT EDIT, V16, P835 MOFFAT JB, 1978, CHEM DIAZONIUM DIA 1 MOFFAT JB, 1979, J MOL STRUCT, V52, P275 NEWTON MD, 1970, J CHEM PHYS, V52, P4064 PIERCE L, 1962, J AM CHEM SOC, V84, P2651 PITTMAN CU, 1974, J ORG CHEM, V39, P373 SCHARPEN LH, 1969, J CHEM PHYS, V50, P2063 SCHMITZ E, 1964, ANGEW CHEM INT EDIT, V3, P333 SCHMITZ E, 1971, 23RD INT C PUR ALL C, V2, P283 SMITH NP, 1979, J CHEM SOC P2, P213 SNYDER LC, 1969, J AM CHEM SOC, V91, P2189 THIEL W, QCPE353 WOLLRAB JE, 1968, J CHEM PHYS, V49, P2405 WOLLRAB JE, 1969, J CHEM PHYS, V51, P1584 YURTSEVER E, 1974, CHEM PHYS LETT, V25, P605; NR: 43; TC: 5; J9: THEOR CHIM ACTA; PG: 7; GA: JW621Source type: Electronic(1
Michael Jones, jazz trumpet
No full textThis Graduate recital features Michael Jones (jazz trumpet), with Ryan Bosick (bass), J. B. Faires (bass), Tyrone Garner II (drums), Tim Gillins (trombone), Travis Wesley Hoover (piano), Josh Marcus (alto sax), and the EIU Jazz Ensemble, directed by Sam Fagalay
Tim Donovan Interview, 2005
No full textIn this 2005 interview, Tim Donovan, Director of the Ohio Canal Corridor, discusses the history of this non-profit organization dedicated to preserving and restoring the Ohio canal and its towpath. Donovan, who grew up on the west side of Cleveland in the 1950s, and attended St. Ignatius High School and Cleveland State University, recounts early jobs he had in the Cleveland area, including working at Jones & Laughlin\u27s steel mills and serving as a Census Bureau surveyor. He was working at J&L during the famous 1969 Cuyahoga River fire. Donovan also worked as a videographer, and it was this occupation which led him to his life\u27s work of preserving the Ohio Canal. In the balance of this interview, he discusses the many efforts he and others made, first to preserve the Warehouse District in the 1980s, and then the Ohio Canal from the mid 1980s to the present (2005). He discusses in detail how the non-profit corporation was built; contributions from the private sector, including American Steel & Wire and Alcoa; and critical federal preservation legislation passed during the Clinton Administration
Tim Donovan Interview, 2005
No full textIn this 2005 interview, Tim Donovan, Director of the Ohio Canal Corridor, discusses the history of this non-profit organization dedicated to preserving and restoring the Ohio canal and its towpath. Donovan, who grew up on the west side of Cleveland in the 1950s, and attended St. Ignatius High School and Cleveland State University, recounts early jobs he had in the Cleveland area, including working at Jones & Laughlin\u27s steel mills and serving as a Census Bureau surveyor. He was working at J&L during the famous 1969 Cuyahoga River fire. Donovan also worked as a videographer, and it was this occupation which led him to his life\u27s work of preserving the Ohio Canal. In the balance of this interview, he discusses the many efforts he and others made, first to preserve the Warehouse District in the 1980s, and then the Ohio Canal from the mid 1980s to the present (2005). He discusses in detail how the non-profit corporation was built; contributions from the private sector, including American Steel & Wire and Alcoa; and critical federal preservation legislation passed during the Clinton Administration
by Glen Norcliffe, Una Brogan, Peter Cox, Boyang Gao, Tony Hadland, Sheila Hanlon, Tim Jones, Nicholas Oddy, and Luis Vivanco (eds)
No full textDekker H-J. Book Review: by Glen Norcliffe, Una Brogan, Peter Cox, Boyang Gao, Tony Hadland, Sheila Hanlon, Tim Jones, Nicholas Oddy, and Luis Vivanco (eds). The Journal of Transport History. 2023;44(2):330-332
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