112 research outputs found
1990-1998 : La genèse d'un bassin parisien politique
No full textUnder the last ten years, the Paris Basin has been the stage for attempts in cooperation in regional planning and of struggles between the local governments of different levels. The author has been following the process as academic as well as consultant. This paper gives her analysis of the changing strategies of the local governments in this period, which appears as a first step in building of a political Paris Basin.La dernière décennie a vu la mise en place d'un jeu d'acteurs complexe dans le Bassin Parisien. L'auteur, qui a participé à ces débats comme universitaire mais également comme consultant de l'Association des Villes du Grand Bassin Parisien, propose ici une réflexion sur le couple discours/action, en montrant les équilibres qui peu à peu se construisent à travers ce foisonnement politique. Elle tente de faire un bilan des acquis de cette période qui est bien une étape dans un chemin qui reste largement à parcourir si le Bassin Parisien doit gagner en cohérence et en lisibilité.Geppert-Hebrard Anna. 1990-1998 : La genèse d'un bassin parisien politique. In: Travaux de l'Institut Géographique de Reims, vol. 25, n°97-98, 1998. Le bassin parisien : un espace en construction, sous la direction de Anna Geppert-Hebrard . pp. 121-131
An exploration of the relationship between language choice in CEO letters to shareholders and corporate reputation
No full textThis paper proposes a taxonomy to assist in more clearly locating research on aspects of the association between corporate reputation and corporate accountability reporting. We illustrate how our proposed taxonomy can be applied by using it to frame our exploration of the relationship between measures of reputation and characteristics of the language choices made in CEO letters to shareholders. Using DICTION 5.0 software we analyse the content of the CEO letters of 23 high reputation US firms and 23 low reputation US firms. Our results suggest that company size and visibility each have a positive influence on the extent to which corporate reputation is associated with the language choices made in CEO letters. These results, which are anomalous when compared with those of Geppert and Lawrence (2008), highlight the need for caution when assessing claims about the effects on corporate reputation arising from the language choice in narratives in corporate annual reports. Author has checked copyrightDG 16/11/12Names JG 2012-11-1
Do Individuals Recognize Cascade Behavior of Others? - An Experimental Study -
No full textIn an information cascade experiment participants are confronted with artificial predecessors predicting in line with the BHW model (Bikchandani et al., 1992). Using the BDM (Becker et al., 1964) mechanism we study participants' probability perceptions based on maximum prices for participating in the prediction game. We find increasing maximum prices the more coinciding predictions of predecessors are observed, regardless of whether additional information is revealed by these predictions. Individual price patterns of more than two thirds of the participants indicate that cascade behavior of predecessors is not recognized.Information Cascades, Bayes' Rule, Decision Under Risk and Uncertainty, Experimental Economics.
Fuzzy Matched Pairs: A Means To Determine the Pharmacophore Impact on Molecular Interaction
No full text
Let us teach for real!
No full textBefore we even noticed, electronic devices and the internet have invaded our lives and our universities. Far from being just an instrument, they change the way we teach, whether we want it or not. Unfortunately, instead of helping, they carry negative effects, well documented by research in psychology, psychiatry and neuroimaging over the last decade. They affect our attention, our memory, and our social skills. Without even being aware of it, we are playing the Sorcerer’s Apprentice. Since 2011, the author has banned the digital and reinvigorated traditional teaching methods: a demanding, yet hugely rewarding experience. The present paper is a vibrant plea by a scholar to fellow scholars: let us get rid of the virtual! Let us teach for real
Record documentation of AFTO 781 series in the aspect of safety of operation of F-16 aircraft at Poznan - Krzesiny airport. Analysis of experience in 2010 - 2020
No full textThe purpose of the article is to present the conclusions and discuss the results of research outcome from the implementation and use of AFTO 781 record documentation in the formation of safety in the process of operation of a multirole aircraft F-16 C/D Block 52+ at Poznan - Krzesiny Airport in 2010 - 2020. Methods: Surveying and analyzing archival documents for comparison in the context of verifying the reliability of data. Results: The result of the conducted research is the presentation of research results and conclusions resulting from several years of use of AFTO 781 record documentation in the process of operation of F-16 C/D Block 52+ multirole aircraft at Poznan - Krzesiny Airport in 2010 - 2020. Conclusions: The main objective of the conducted study was to define the factors determining the functionality of the AFTO 781 series record documentation, in the process of maintaining a certain level of safety in the operation of F-16 aircraft. In addition, the analysis of the results of the study allowed the author to interpret the ability of technical personnel to use the functionality of the AFTO 781 series record documentation in question, as well as to define the following conclusions and proposals for action, in order to minimize the occurrence of potential risks in the operation of aircraft equipment in the future
Context-Based Identification of Protein-Protein Interfaces and “Hot-Spot” Residues
No full textSummaryReliable determination of protein-protein interaction sites is of critical importance for structure-based design of small molecules modulating protein function through macromolecular interfaces. We present an alignment-free computational method for prediction of protein-protein interface residues. The method (“iPred”) is based on a knowledge-based scoring function adapted from the field of protein folding and small molecule docking. Based on a training set of 394 hetero-dimeric proteins iPred achieves sustained accuracy on an external unbound test set. Prediction robustness was assessed from more than 1500 diverse complexes containing homo- and hetero-dimers. The technique does not rely on sequence conservation, so that rapid interface identification is possible even for proteins for which homologs are unknown or lack conserved residue patterns in interface region. Functional “hot-spot” residues are enriched among the predicted interface residues, rendering the method predestined for macromolecular binding site identification and drug design studies aiming at modulating protein-protein interaction that might influence protein function. For a comparative structural model of peptidase HtrA from Helicobacter pylori, we performed mutation studies for predicted hot-spot residues, which were confirmed as functionally relevant for HtrA activity or oligomerization
Cooling rates of neutron stars and the young neutron star in the Cassiopeia A supernova remnant
No full textWe explore the thermal state of the neutron star in the Cassiopeia A supernova remnant using the recent result of Ho & Heinke that the thermal radiation of this star is well described by a carbon atmosphere model and the emission comes from the entire stellar surface. Starting from neutron star cooling theory, we formulate a robust method to extract neutrino cooling rates of thermally relaxed stars at the neutrino cooling stage from observations of thermal surface radiation. We show how to compare these rates with the rates of standard candles – stars with non-superfluid nucleon cores cooling slowly via the modified Urca process. We find that the internal temperature of standard candles is a well-defined function of the stellar compactness parameter x=rg/R, irrespective of the equation of state of neutron star matter (R and rg are circumferential and gravitational radii, respectively). We demonstrate that the data on the Cassiopeia A neutron star can be explained in terms of three parameters: f?, the neutrino cooling efficiency with respect to the standard candle; the compactness x; and the amount of light elements in the heat-blanketing envelope. For an ordinary (iron) heat-blanketing envelope or a low-mass (? 10?13 M?) carbon envelope, we find the efficiency f?? 1 (standard cooling) for x? 0.5 and f?? 0.02 (slower cooling) for a maximum compactness x? 0.7. A heat blanket containing the maximum mass (?10?8 M?) of light elements increases f? by a factor of 50. We also examine the (unlikely) possibility that the star is still thermally non-relaxe
Distinct Roles of Secreted HtrA Proteases from Gram-negative Pathogens in Cleaving the Junctional Protein and Tumor Suppressor E-cadherin
No full textHoy B, Geppert T, Boehm M, et al. Distinct Roles of Secreted HtrA Proteases from Gram-negative Pathogens in Cleaving the Junctional Protein and Tumor Suppressor E-cadherin. Journal of Biological Chemistry. 2012;287(13):10115-10120.The periplasmic chaperone and serine protease HtrA is important for bacterial stress responses and protein quality control. Recently, we discovered that HtrA from Helicobacter pylori is secreted and cleaves E-cadherin to disrupt the epithelial barrier, but it remained unknown whether this maybe a general virulence mechanism. Here, we show that important other pathogens including enteropathogenic Escherichia coli, Shigella flexneri, and Campylobacter jejuni, but not Neisseria gonorrhoeae, cleaved E-cadherin on host cells. HtrA deletion in C. jejuni led to severe defects in E-cadherin cleavage, loss of cell adherence, paracellular transmigration, and basolateral invasion. Computational modeling of HtrAs revealed a conserved pocket in the active center exhibiting pronounced proteolytic activity. Differential E-cadherin cleavage was determined by an alanine-to-glutamine exchange in the active center of neisserial HtrA. These data suggest that HtrA-mediated E-cadherin cleavage is a prevalent pathogenic mechanism of multiple Gram-negative bacteria representing an attractive novel target for therapeutic intervention to combat bacterial infections
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