723 research outputs found
The role of TIM-containing molecules in airway disease and their potential as therapeutic targets
No full textIsabel Vega-Carrascal, Emer P Reeves, Noel G McElvaneyRespiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, IrelandAbstract: T cell immunoglobulin and mucin-domain (TIM)-containing molecules have emerged as promising therapeutic targets to correct abnormal immune function in several autoimmune and chronic inflammatory conditions. Despite the initial discovery linking TIM-containing molecules and the airway hyperreactivity regulatory locus in mice, there is a paucity of studies on the function of TIM-containing molecules in lung inflammatory disease. Initially, studies were limited to mice models of asthma. More recently however, TIM-containing molecules have been implicated in an ever-expanding list of airway conditions that includes pneumonia, tuberculosis, influenza, sarcoidosis, lung cancer, and cystic fibrosis. This present review discusses the role of TIM-containing molecules and their ligands in the lung, as well as their potential as therapeutic targets in airway disease.Keywords: T cell immunoglobulin and mucin-domain, inflammation, galectin-9, airway diseas
Evolving biocomplexity: Experimental studies on the evolution of protein complexes and ecological diversity
No full textBN/Bertus Beaumont La
Les Beaumont-Navarre: notes historiques et généalogiques
No full textSe da la genealogía de los Beaumont-Navarra que aunque ha sido muy estudiada, el autor considera que ha habido errores y en algunos casos no está completa por lo que merece la pena presentar sus descubrimientos y diversos documentos en los que se encuentra la informaciónThe genealogy of the Beaumont-Navarres is introduced although it has previously been the subject of many a study, the author considers there have been mistakes and in some instances it is not even completeit is therefore worth the trouble for the author to introduce his discoveries and the various documents in which such information is to be found
C. Beaumont Wicks index, MSS.1552
No full textAbstract: Index cards, in French, that contain the author and a description of the work including the date.Scope and Content Note: The collection contains index cards, written in French, that contain the author and a description of the work being indexed, including the date.Biographical/Historical Note
The Dearth of the Author: Philip Massinger and the Beaumont and Fletcher Folio
No full textIn 1647, Humphrey Moseley and Humphrey Robinson published a folio collection of unpublished works which they attributed to Francis Beaumont and John Fletcher, two writers famous for their collaborations from 1606 to 1613. But in affording Beaumont a place on the title page, the publishers misattributed the volume. Scholars now accept that Beaumont had very little direct input in the collection whereas Philip Massinger, who began collaborating with Fletcher soon after Beaumont’s retirement, had a very significant, unacknowledged role in the collected plays. This essay offers the first extended discussion of why it was that Massinger was written out of this canon-defining volume. I argue first that Massinger was by many accounts a popular and vendible dramatist, whose omission from the folio had little to do with him having a poor reputation. Instead, I suggest that the reputation of the names Beaumont and Fletcher, established in the preceding decades, proved irresistible to the publishers. Furthermore, I argue that Massinger’s reputation as a distinctive solo playwright also counted against him, making it harder to apprehend him as a prolific collaborator. Next, I demonstrate how the 1647 folio participated in a process of canonization which elided Massinger’s significant collaborative contribution and discuss the distorting effect this has had on our understanding of Beaumont, Fletcher, Massinger, and playwrighting practice more broadly. I end by pointing towards some ways of rectifying the historical elision of Massinger’s collaboration with Fletcher
Introduction: Research Aims and Methodology
No full textThis is the author accepted manuscript. The final version is available from Hart Publishing via the link in this record
Effective remedies in cross-border civil and commercial law disputes: a case for an institutional reform at EU level
No full textThis is the author accepted manuscript. The final version is available from Hart Publishing via the link in this record
Les Lumières de Marie Leprince de Beaumont. Nouvelles données biographiques
No full textStory-teller, journalist, novel-writer, well-thinking author, Marie Leprince de Beaumont (1711-1780) has a very contrasted reputation. Some of her contem¬ poraries judged her to be a dull and duplicitous bigot ; on the other hand, some of our contemporaries, following nineteenth-century editors of her edifying books, wrote her hagiography, or at least undervalued her confession written in an autobiographical letter published in 1906. The correspondence between her and her friend, lover, or husband, Thomas Pichon-Tyrrell (1700-1781), as well as several recently discovered archive documents, allow us to paint the picture of an independent woman, a female author conscious of her mission and a business woman, an adventurer, a Christian philosopher, perhaps a true 'femme des Lumières.Artigas-Menant Geneviève. Les Lumières de Marie Leprince de Beaumont. Nouvelles données biographiques. In: Dix-huitième Siècle, n°36, 2004. Femmes des Lumières. pp. 291-301
Wordsworth’s Epistle to Sir George Beaumont: the road twice taken
No full textHere, I investigate a later Wordsworth poem in its markedly different 1811 and 1842 versions – the verse epistle to Sir George Beaumont. This epistle, calling upon the country house poems developed by Ben Jonson and upon the topographical rambling of Wordsworth’ own youthful verse, should be seen as an attempt to update to new contexts an old form in which the address of patron by poet had modelled a virtuous sociability exemplified in the moral community of the country estate. His epistle, a missive from a domestic journey that is chatty and yet ordered, reveals Wordsworth forging verse-conditions to reshape the inherited model, so that exemplary community takes the form of intimate, domestic sociability based on the dales family rather than the landed estate. It represents an alternative both to the blank-verse celebration of rustic society that had stalled in ‘Home at Grasmere’ and to the rustic speech that, in 1798, 1800 and 1807, had narrated the troubles of rural folk.
Examining the greatly expanded version of 1842, I discuss the role of revision as a mode of renewing the past in which celebratory revival conceals elegiac regret (Wordsworth’s effort to renew destroyed community by writing as if that destruction had not yet occurred revives both the community and the consciousness of its loss). I explore its peculiar tone, its fascinating double perspective, and the complex literary allusions in which the undisclosed fact of death is accommodated, if not resolved
Sites in the imagination: The Beaumont Hamel Newfoundland Memorial on the Somme
No full textThe Beaumont Hamel Newfoundland Memorial is a 16.5-hectare (40 acres) tract of preserved battleground dedicated to the memory of the 1st Newfoundland Regiment, who suffered an extremely high percentage of casualties during the first day of the Battle of the Somme in July 1916. Beaumont Hamel Memorial is an extremely complex landscape of commemoration where Newfoundland, Canadian, Scottish and British imperial associations compete for prominence. It is argued here that those who chose the site of the Park, and subsequently reordered its topography, helped to contrive a particular historical narrative that prioritized certain memories over others. In its design, the park has been arranged to indicate the causal relationship between distant military command and immediate frontline response, and its topographical layout focuses exclusively on a 30-minute military action during a 50-month war. In its preserved state the part played by the Royal Newfoundland Regiment can be measured, walked and vicariously experienced. Such an achievement has required close semiotic control and territorial demarcation in order to render the 'invisible past' visible, and to convert an emptied landscape into significant reconstructed space. This paper examines the initial preparation of the site in the 1920s and more recent periods of conservation and reconstruction. The author examines precedents for the preservation of battlefields, the spatiality of commemoration and the expectations aroused by such sites of memory. By focusing on the Beaumont Hamel memorial site the author explores several areas of contention: historical accuracy, topographical legibility and freedom of access. © 2004 Arnold
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