101,160 research outputs found
Long noncoding RNAs and microRNAs in cardiovascular pathophysiology
No full textRNAs not encoding proteins have gained prominence over the last couple of decades as fundamental regulators of cellular function. Not surprisingly, their dysregulation is increasingly being linked to pathology. Here, we review recent reports investigating the pathophysiological relevance of this species of RNA for the cardiovascular system, concentrating mainly on recent findings on long noncoding RNAs and microRNAs in cardiac hypertrophy and failure
Interplay between European regulation and national policies in biodiversity conflict reconciliation
No full textSuccessful public conservation policies at various governmental levels have increased some populations of protected species to the extent that they are causing damage to human activities. As a reaction public authorities are developing biodiversity reconciliation policies. Finland and Germany have both created reconciliation policies including a package of measures like management of population, support of technical measures and compensation for damage. All these measures are affected by European policy and law, though no special reconciliation policy has been adopted at European level. This article explores the options European legislation offers and the restrictions it imposes on member states. Based on experiences with German and Finnish biodiversity reconciliation policies, the interrelationship between European and national regulation is elaborated, leading to suggestions for better coordination of reconciliation policies between different governmental levels. --Biodiversity conflict reconciliation,European regulation,fisheries and aquaculture,local damage management,nature conservation,policy instruments
Yermessungskunde fiir Kartographen-ll par Richard Koitzsch (en collaboration avec E. Thum et M. Döhler)
No full textLibault André. Yermessungskunde fiir Kartographen-ll par Richard Koitzsch (en collaboration avec E. Thum et M. Döhler). In: Annales de Géographie, t. 73, n°397, 1964. pp. 339-340
Debating new strategies for cardiac protection in the ageing heart in Naples, Italy: news from the joint meeting of the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart
No full textLetter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
Circulating miRNAs as mediators in cell-to-cell communication
No full textSince their discovery in the blood circulation in 2008 [1], miRNAs have emerged as the subclass of the noncoding RNA superfamily that has gained most attention in biomarker development. Due to their biochemical properties, the number of publications that have explored the clinical application of circulating miRNAs as diagnostic and prognostic indicators of cardiovascular disease has grown exponentially over the last decade [2]. Surprisingly, despite the enormous research and economic interest, the biology of these small noncoding RNAs in circulation is far from being completely understood.This work was supported by Deutsche Forschungsgemeinschaft (Grant Number BA5631/2-1 to C Bär) and KFO311 (to T Thum). D de Gonzalo-Calvo was a recipient of Juan de la Cierva-Incorporación grant from the Ministerio de Economía y Competitividad (IJCI-2016-29393). CIBER Cardiovascular (CB16/11/00403) is an Instituto de Salud Carlos III Project. T Thum has filed and licensed patents in the field of noncoding RNAs. T Thum is founder and holds shares of Cardior Pharmaceuticals GmbH
Handwritten biographical information on Paulina T. McClung Merritt
No full textA handwritten biography of Paulina T. McClung Merritt by an unknown author, 1892.
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
No full textIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Pelevin’s Trinity in the novel “t”: author – protagonist – reader
No full textThe article attempts to interpret Pelevin's artistic strategy in the novel "T" by exploring its subject organization and addressing the key problems of the author, the protagonist, and the reader as they are seen by the researcher. The article analyzes the peculiarities of constructing the narrative reality in the novel "T", and goes on to discuss Pelevin's philosophic models of the development of the humankind, and the emergence of his new anthropology
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