1,721,036 research outputs found
Reperfusion in the brain: is time important? The DAWN and DEFUSE-3 trials
No full text(Opening paragraph) Reperfusion therapy using intravenous thrombolysis and mechanical thrombectomy are the only approved treatments for acute ischaemic stroke, but must be administered in a narrow therapeutic window of up to 4.5 and 6 h, respectively. A further meta-analysis by the HERMES (Highly Effective Reperfusion evaluated in Multiple Endovascular Stroke Trials) collaboration has suggested that mechanical thrombectomy may be beneficial up to 7.3 h after stroke onset. However, the results of the DAWN (DWI or CTP Assessment with Clinical Mismatch in the Triage of Wake-Up and Late Presenting Strokes Undergoing Neurointervention with Trevo) and the DEFUSE 3 (Endovascular Therapy Following Imaging Evaluation for Ischaemic Stroke)7 trials may extend this window up to 24 h in carefully selected patients
Reperfusion in the brain: is time important? The DAWN and DEFUSE-3 trials.
No full text(Opening paragraph) Reperfusion therapy using intravenous thrombolysis and mechanical thrombectomy are the only approved treatments for acute ischaemic stroke, but must be administered in a narrow therapeutic window of up to 4.5 and 6 h, respectively. A further meta-analysis by the HERMES (Highly Effective Reperfusion evaluated in Multiple Endovascular Stroke Trials) collaboration has suggested that mechanical thrombectomy may be beneficial up to 7.3 h after stroke onset. However, the results of the DAWN (DWI or CTP Assessment with Clinical Mismatch in the Triage of Wake-Up and Late Presenting Strokes Undergoing Neurointervention with Trevo) and the DEFUSE 3 (Endovascular Therapy Following Imaging Evaluation for Ischaemic Stroke)7 trials may extend this window up to 24 h in carefully selected patients
WSO897858 Supplemental material2 - Supplemental material for Validation of the simplified modified Rankin scale for stroke trials: Experience from the ENCHANTED alteplase-dose arm
No full textSupplemental material, WSO897858 Supplemental material2 for Validation of the simplified modified Rankin scale for stroke trials: Experience from the ENCHANTED alteplase-dose arm by Xiaoying Chen, Jingwei Li, Craig S Anderson, Richard I Lindley, Maree L Hackett, Thompson Robinson, Pablo M Lavados, Xia Wang, Hisatomi Arima, John Chalmers, Candice Delcourt and for the ENCHANTED Investigators in International Journal of Stroke</p
WSO897858 Supplemental material1 - Supplemental material for Validation of the simplified modified Rankin scale for stroke trials: Experience from the ENCHANTED alteplase-dose arm
No full textSupplemental material, WSO897858 Supplemental material1 for Validation of the simplified modified Rankin scale for stroke trials: Experience from the ENCHANTED alteplase-dose arm by Xiaoying Chen, Jingwei Li, Craig S Anderson, Richard I Lindley, Maree L Hackett, Thompson Robinson, Pablo M Lavados, Xia Wang, Hisatomi Arima, John Chalmers, Candice Delcourt and for the ENCHANTED Investigators in International Journal of Stroke</p
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Supplemental material for Building a European ‘network of networks’ for stroke clinical research – The European Stroke Organisation Trials Alliance (ESOTA)
No full textSupplemental Material for Building a European ‘network of networks’ for stroke clinical research – The European Stroke Organisation Trials Alliance (ESOTA) by Peter Kelly, Rustam A Salman, Anita Arsovska, Diederik WJ Dippel, Urs Fischer, Gary A Ford, Blanca Fuentes, Robin Lemmens, John C Marshall, Paul J Nederkoorn, Thompson Robinson, Christian Weimar, Eivind Berge and on behalf of the ESO Trials Network Committee ESOTA Steering Group in European Stroke Journal</p
A qualitative study exploring how stroke survivors' expectations and understanding of stroke Early Supported Discharge shaped their experience and engagement with the service
Full text linkPurpose:
To explore how stroke survivors’ expectations and understanding of Early Supported Discharge (ESD) helped them make sense of their experiences, and shaped their engagement with the service.
Methods:
Data were collected as part of a study of large-scale implementation of stroke ESD: the WISE realist mixed-methods study. Semi-structured interviews were conducted with five purposefully selected stroke survivors from six sites in England implementing stroke ESD (n = 30). Participants were aged 32–88 years (20 males). Interviews were audio recorded, transcribed verbatim and transcripts were analysed using reflexive thematic analysis.
Results:
Three overarching themes were identified: (1) ESD as a post-stroke recovery tool, (2) desire to recover quickly, (3) psychosocial impact and support. Stroke survivors were uncertain about what to expect when they first entered the service, however, their experience of ESD exceeded their expectations and increased their engagement with the service. Stroke survivors especially valued the goal-oriented approach the team adopted. Rehabilitation at home was perceived as positive and practical, encouraging independence within real-life contexts. Psycho-social support played an important role in the stroke survivors’ rehabilitation.
Conclusions:
Ensuring stroke survivors are fully informed about ESD and what to expect, optimises engagement with the services, improves experience and could enhance outcomes
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