17 research outputs found
Prevotella denticola Lipopolysaccharide from a Cystic Fibrosis Isolate Possesses a Unique Chemical Structure
No full textWe report the first complete structural characterization of the lipopolysaccharide (LPS) from a cystic fibrosis (CF) clinical isolate of Prevotella denticola (B003V1S1X). Chemical, spectroscopic, and spectrometric analyses revealed a unique rough-type LPS (LOS) structure. The structure has a highly negatively charged heptasaccharide core region containing hexoses, with the first two sugars, 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) and mannose, highly phosphorylated. Furthermore, the lipid A moiety has the typical structure for the genus Prevotella, and was also highly phosphorylated.</p
Cornell Confronts the End of Mandatory Retirement
No full text[Excerpt] In July 1995, the first author of this paper was appointed vice president of academic programs, planning and budgeting at Cornell and, at his initiative, a joint faculty-administrative committee was subsequently established, with him as chair, to look into how the university should respond to the elimination of mandatory retirement. In this chapter, we discuss the environment in which the university found itself when the committee was established, the recommendations of the committee, faculty reactions to the recommendations, and the actions that the university ultimately decided to pursue
A Stochastic Simulation Framework for the Government of Canada's Debt Strategy
No full textDebt strategy is defined as the manner in which a government finances an excess of government expenditures over revenues and any maturing debt issued in previous periods. The author gives a thorough qualitative description of the complexities of debt strategy analysis and then demonstrates that it is, in fact, a problem in stochastic optimal control. Although this formal definition is conceptually useful, the author recommends the use of simulation to help characterize the set of strategies that a government can use to fund its borrowing requirements. He then describes in detail a stochastic simulation framework, building from previous work in Bolder (2001, 2002); this framework forms one important element in the debt strategy decision-making process employed by the Government of Canada. The primary objective in constructing this stochastic simulation framework is to learn about the nature of the risk and cost trade-offs associated with different financing strategies. To this end, the paper includes a detailed description of the model; a set of possible debt cost and risk measures, including one potentially useful conditional risk measure; illustrative results under normal stochastic conditions; an analysis of the sensitivity of the results to various key model parameters; a novel approach to stress testing; and a possible framework for selecting a financing strategy, given assumptions about government risk preferences.Debt management; Econometric and statistical methods; Economic models
Monetary and Fiscal Policies in Canada: Some Interesting Principles for EMU?
No full textChoosing a well-designed framework for fiscal and monetary policies is a challenge for economic authorities. Although they have chosen the same objectives to promote economic growth—price stability and fiscal sustainability—the Canadian and European economic authorities have adopted different frameworks in which to attain them. The author examines some principles of the Canadian framework that have gained broad public support and provide a good degree of macroeconomic stabilization, and examines whether the European authorities might wish to consider adopting some of those principles.Monetary policy framework; Fiscal policy
Attrition from Australian ICT degrees – Why women leave
No full textStudent attrition is of particular concern in the field of ICT because the industry faces staffing shortfalls, generally and a noticeable lack of female employees. This paper explores the reasons female students give for leaving their ICT courses. An online survey of early leavers from four Australian universities was conducted. The results show that, for many students, it is a combination of issues that leads to their withdrawal. Contrary to expectations, few female ex-students had experienced serious life events that necessitated their withdrawal or indicated that negative behaviour or attitudes had contributed to their decision to leave. More commonly female participants cited reasons associated with their lack of expected background knowledge. Recommendations are made to address issues that could be mitigated by university action
Medicaid Policy Changes in Mental Health Care and Their Effect on Mental Health Outcomes
No full textIn recent years, Medicaid has experienced a dramatic increase in spending on prescription drugs in general and psychotropic medications in particular. The purpose of this study is to examine the effects of increased Medicaid spending on psychotropic drugs on improving the mental health and well-being of participants at the population level. Specifically, we study the effect on outcomes that are strongly correlated with mood disorders, including depression, and Attention Deficit/Hyperactivity disorder, controlling for concomitant increases in Medicaid eligibility thresholds and expansion into managed care for mental health services. Knowledge of the effects of changes in the Medicaid program is crucial to policymakers as they consider implementing and expanding mental health services. Our results show that increased spending on antidepressants and stimulants are associated with improvements in some outcomes, but not in others.
Fluorescent Hexose Conjugates Establish Stringent Stereochemical Requirement by GLUT5 for Recognition and Transport of Monosaccharides
No full textFluorescent Hexose Conjugates Establish Stringent Stereochemical Requirement by GLUT5 for Recognition and Transport of Monosaccharides
No full textThe
specificity characteristics of transporters can be exploited
for the development of novel diagnostic therapeutic probes. The facilitated
hexose transporter family (GLUTs) has a distinct set of preferences
for monosaccharide substrates, and while some are expressed ubiquitously
(e.g., GLUT1), others are quite tissue specific (e.g., GLUT5, which
is overexpressed in some breast cancer tissues). While these differences
have enabled the development of new molecular probes based upon hexose-
and tissue-selective uptake, substrate design for compounds targeting
these GLUT transporters has been encumbered by a limited understanding
of the molecular interactions at play in hexose binding and transport.
Four new fluorescently labeled hexose derivatives have been prepared,
and their transport characteristics were examined in two breast cancer
cell lines expressing mainly GLUTs 1, 2, and 5. Our results demonstrate,
for the first time, a stringent stereochemical requirement for recognition
and transport by GLUT5. 6-NBDF, in which all substituents are in the d-fructose configuration, is taken up rapidly into both cell
lines via GLUT5. On the other hand, inversion of
a single stereocenter at C-3 (6-NBDP), C-4 (6-NBDT), or C-5 (6-NDBS)
results in selective transport via GLUT1. An in silico docking study employing the recently published
GLUT5 crystal structure confirms this stereochemical dependence. This
work provides insight into hexose-GLUT interactions at the molecular
level and will facilitate structure-based design of novel substrates
targeting individual members of the GLUT family and forms the basis
of new cancer imaging or therapeutic agents
Natural and human induced late quaternary environmental change on the Noordhoek Valley, Cape Town, South Africa
No full textIncludes bibliographical references (leaves 130-139).This research project attempts to determine the relative influences of climate, sea level changes and human activities during the period of sediment accumulation in the Noordhoek basin in the southwestern Cape. South Africa. The research relies on lacustrine sedimentary deposits and their compositional changes as evidence of the dynamic depositional environments from which environmental conditions are inferred. Data on spatial changes on land surfaces have also been employed to complement the sedimentary chronology from catchments beyond historic records. Assessment of the extent of human influence on the Noordhoek basin has been achieved through comparison with the pristine conditions found on the Cape Nature Reserve. Analysis of dated sediment cores from the Noordhoek valley and the Cape Peninsula Nature reserve has facilitated the reconstruction of major environmental changes for the late Pleistocene and Holocene periods. An extended record of environmental change from the longest core (LM-Core) has enabled environmental reconstruction and the determination of the relative influences of climate, sea level change and human activities on the local! environment of the basin during the late Quaternary. Sedimentological evidence from the cores reveals the long-term evolution of the wetlands as being influenced by fluctuating sea levels and climate change until the mid-Holocene. Short-term environmental processes during the late Holocene. resulting from direct anthropogenic activities such as irrational uses of the wetlands for agriculture and urbanisation are responsible for polluting and transforming the status of the wetlands. Heavy metal concentrations in sediment cores from the two Noordhoek wetlands have allowed the elucidation of recent human impacts. The vertical distribution of these metals correlates with and complements the evidence of spatial changes in land use and land cover. Metal enrichment in the modern Noordhoek wetland sediments and increased organic matter content indicates increasing anthropogenic impacts on the valley as agriculture and urbanisation increased. In comparison. there is a much lower concentration of heavy metals at Groot Rondevlei, as its catchment has been less prone to severe local disturbance such as urban development and recent agricultural activities. The absence of a tightly resolved chronology for these cores restricts the understanding of the commencement and duration of major environmental changes, which have been accounted for elsewhere in the region. This limits the opportunity for direct comparison between this and other known sites. However, the Noordhoek valley is a potential resource for longer-term Quaternary environmental study. The application of a multi-disciplinary approach and high-resolution dating are highly recommended for future research in this area
0005
No full textPAGE SIX
DAILY PALO ALTO TIMES. WEDNESDAY, JULY 31, 1912.
SPLITTING
kindling costs more time
and takes more trouble
than it is worth. We split
kindling by the cord and
can sell it to you cheap.
Free Delivery.
Order Oak Stovewood
from us.
WORRELLS
Oppoalte Freight Depot.
PHONE SS.
I-HO.NK 07.
OOVKRKMKNT INtPRCrrwi)
REFRIOKRATEr- MKATH
at she
. Stanford Meat Co
304 I'tiiventity A-rnaatv
DELICACIKkt, POULTRY.
Fresh fish every f rids*
NOTICE TO BIDDERS.
Sealed proposals will be received
by the Board ot Public Works of the
City of Palo Alto for the construction of a Garbage Incinerator Plant,
until & o'clock p. 111. on tbe 6th day
of August, 1912.
Proposals must be on blanks to
be /urnlshed by the City of Palo
Alto and must be accompanied by a
certified check on some solvent
bank In an amount equal to fi per
cent of the bid, payable to tha City
Clerk, as a guarantee that contract
will be entered Into If proposal be
accepted.
Specifications may be secured *nt
the odlce of the City Clerk of the
City of Palo Alto.
Tbe Board of Public Works reserves tbe right to reject any and
all bids.
FRANK KASSON.
7-6-tm City Clork.
At the Top of the Woolworth
Building, Tallest In the World
F. W. Sherman
Furniture Packed
and Shipped
CITY
Garbage Co.
L. PONZ1NI
A postal will brlnt
the manager u
yonr address a*
once. Oar sddr***
la P. O. Box 4C1
Palo Alto
437 Wens-Mta- SL
P. L. SEAMANS
THE LEADING JEWELER
Largest and Most Complete Otoe*
Ever Brought to Palo Alto.
Only Kngr.iT.-r Id Palo Alto.
What We Say It Is It Is.
AU Goods Kb-t-rsved Free.
Week's Poultry Ranch
will sup, your table wlta cttols*
anllk-fatt«ned poultry, dressed ant
tri-Mse-d, ready to cook, and dellveree
*o yonr door. Order over phone*
77IX. Ranch located on Hamlltos
extension, Palo Alto.
renchLaundry
at. J. FAIRFIELD, Msiiagei
Forest Are and Ramona «t.
registered optician.
H. BLEIBLER
Blacksmlthtnc—701 High St.
Wagons and carriage work.
Rubber tires a specialty.
PHONB BS1X
4>»seeas*M.«>»».inn*»
We Ilnnrll.
ROHNER'S IIOMi-MAIig
CATtUP
A Palo Alto Article.
•a. W. LA PEIRE * »ON.
Photo copyright. 1S13, by American Press Association.
THE last piece of steel was recently riveted lo place on the Woolworth
bulldlog, in City Hall square. New York city, the tallest habitable
building ln tbe world. Tbe photograph here reproduced show* tne
workmen at tbe top of the structure celebrating the event. It also
shows a number of downtown New York offlce buildings, dwarfed by the
gigantic proportions of the Woolworth. This building la fifty-five stories ln
height, and Its lower light, *ioO feet in the air. will te visible nlncty-alz miles
at sea. 1U total cost will be abont 13,000,000. Tbls Includes the cost of the
land on whlch*1t stands—84.500.000. Tbe floor spnee will be about twenty-
three acres, wltb room for 2.0UO offices, wblcb will accommodate aboot 10,000
people. The rent roll Is expected to be somewhere In the nelghbornood of
tK.W0.U00 a year. Cass Gilbert is the architect -.'he new building will he
fifty feet higher than the Metropolitan tower. 138 feet higher than tba Singer
building and 243 feet higher than tbe Washington monument. Tne EllTel
tower, in Paris. Is 9S5 feet high, but that la not a building.
NOTICE OF SALE OP REAL
TATE AT PRIVATE SALE.
ES-'
F*t» of Alclbisd**.
The brilliant, witty and dissolute
j AlcLbinde* had one of tbe most cxtcn
In the Superior Court of the City aire experiences^ln exile^ that ever fell
aud County of San Fntnclttco,
State of Cnllfomln.
Action No. 11H74 N. S.
ment No. O—Probate.
Business
An offer wtnted for lot,
with improvement; 100xJ06
corner Alma and Homer.
Apply to
John F. Byxbee.
101 LMIi.n Are., Palo Alto. Cal.
,**,,,.,,...,,»,,...,,.....
AUTOMOBILE AND CARRIAGE PAINTER
HERMANN DOSB
MONOGRAMS AND SIGN*
IS High St, Phoae SS1X
la
TRY POLARINE HEAVY ot
OUR SPECIAL AUTO OIL
for automobile lubrication.
sale only ny tne
G. H Allen Oil Co
890 High Street, Palo Als*.
ror
Recommended For
Indigestion
ASTEURIZED
INE NECTAR
-.ASANTEST
DRINK
RESSEI) from
ma
INEAPPLE8
Madx H-THawaii HONK 0«SL
Palo Alto Soda WorKs
DISTRIBUTORS 31H High Street
In the Matter of
| THOMAS RIDOUT, I>ecca*ed.
Notice Is hereby given that ln
{pursuance of an order of tho Su-
jperior Court of the City and County
! of San Frnnclsco. State of Califor-
; nla. made, filed and entered on the
' 2d day of Keb>-uary. 1912, In the
matier of the estate or Thomas
| Kid-out. deceased, the undersigned
{ Executors of the Last Will and Tes-
| lament of said dot eased will sell at
private sale the following described
] property, to wit:
| All those certain lots, pieces or
j parcels of land situate, lying and
being In the County of Santa Clara.
State of California. ' bounded and
particularly described as follows, to
wit: Lots numbered Five (5) and
Six (6) In Block numbered Thirty-
one. (31). ln South Palo Alto,
to tbe lot of man. While lh command of tbo Sicilian army be was recalled to stand trial for the dc»truction of the busts of Hermes, tin
Depart. rage t]iftt lmi.1 taken place hint before
his departure. Knowing that hi*
death had been determined on. be es-
tln* E*tate of- caped to Siiarta. where, by adopting
tbe manuetr* of the people. In strange
contrail to bis former style of luxury,
be became Immensely popular. He cn-
gngod In military o|x*rntlou* against
the Athenians and succeeded So well
as to excite the envy of the Spartun
leader*, who expelled him. whereupon
be went to Persia nnd lived there with
l magnlllceu'-e that astonished
Persians themselves. He was l-vcalled
to Athena wllh thc same caprli-limn
ncss that innrkcd bis ostracism and
was iip|K)1ntetl commander In chief of
nl) the Athenian forces- but, falling in
an Important expedition, he was again
sent Into exile and was finally nssaa-
slnated Id Persia.
NO HEAL IS COMPLETE
without our pure bread. Each bits
Invites another, because It Is ao alluringly palatable. Try a loaf today. After your family bas eaten
It once, you will And them asking
for It at breakfaat, dinner and* supper. This baa been proved a fact.
Prove lt for your own satlsfsctloa i
HfiRWKCK'g BAKERY
*»* + ♦ »*..»*
ELITE MARKET
STEIERT A PHILLIPS
Proprietor*.
Phone 7.. 218 fnlveralty Are. ,
Inspected meats, No. 1 grade
hams and batcons, flab, poultry and delicacies.
•a * a a •****■»■* *
a a ** »■» + ■>
WEIGH OUR COAL
and you'll find a toa weighs 2,000
pounds without the driver, Just
ton of coal, nothing else. Tbls Is
the beat time to buy coal. Wa are
In a position to know, for we bave
looked over the field. Better let n*
flll your wanta now.
M. C. FORD
ffit-s Hsmlhoa Avenne. Phono 60.
Clearance Sale
Closing out Odd Lots and Short
-Sets at a Bargain
See Our Window
BIXBY & LILUIE
HIGH GRADE GROCERS
A Fashion Thst Failed.
Charles II- attempted to put down
the mutnbllity of fashion—in masculine costume On Oct 0, 1CGC, as
Pepys record-t. the king declared in
council "bis resolution of setting
fashion In clothes, wblcb be will never
__ slter. It will be a vest I know not
pe'r Map on"fllo".oThe" offlce'oV'the! JP*bc*W. but It Is to tweb the nobility
County Recorder of said Santa 1*!™*" w,n f° *%£i Jga*S
„. _ »■«*.*. Istor Pepys wees tbe Duke of Vork tr>
Clara County and filed therein on! on thfi MW ,.vwt„ wulch ,„ nBnI(l (U.
May 15, 1905 {Map Book "K," clnrw* to -*, |-ka [bo Inws of thc Medc*
pago 751. ondorsed "Map No. 2 off an(* Pcrslaua It wns "a long cassock
the Seale Addition to the Town of! close to tbe body, of black ciotb aud
Palo Alto."—and the Improvements! pinked wltb white silk under lt. and a
thereon consisting of a flve-room! coat over It and the legs ruffled with
barn and other outbuild- bloc* ribbon like a pigeon'* leg" But
Louts XIV. maliciously dressed all bis
cottage,
logs.
Said salo will be made on or Oftoi
MONDAY, thc 12th day of August,
1912, and bids muBt be In writing
and will be received at the ofSce of
M. T. Moses, Room 518 David
Hewes Building. No. 995 Market
street, In the City and County of
San Francisco. State of California
or may be delivered to tba undersigned' Executors personalty or may
be filed In tbe office of the Clerk of
said Court, and said property will
be aold. subject to the confirmation
of such sale by the said Superior
Court, to tho highest bidder, and
tho terms of said sale are: Cash
ln gold coin of the United Stat***i of
America. A deposit of ten (10) per
cent ot the amount of such sale
shall be made with tbe undorsignad
Executors by the purchaser at the
time of tri acceptance of any such
bid nnd the making of such sale by
said Erocutors, and the ba'ianco
shall be paid on tbe delivery of
deed of conveyance and after confirmation of sale as aforesaid.
Dated. San Francisco. California
July 19. 1912.
EMORY A. DAVIS,
WALTER H. BLUNDEN,
Executors of tbe Last Will and
Testament of Thomas Rldout,
deceased.
M. T. MOSES, Attorney for said
Executor*. David Hewes Bulldlag,
No. 995 Market street. San Fran-
*.lsco, California.
7-16*1 It
footmen ln this costume, and so did
French noblemen, wltb tho result thot
the English court very soon discarded
tbe "unalterable" costume.
MISS MARGARET WILSON.
Eld**t DsuflhUr ot Democratic Nomine* For th* Prasidtmcy.
Notice to Bidders
Sealed proposals will be received
by tho Board of Public Works of
the City of Palo Alte for tbe construction of a Reinforced Concrete
Building for tbe Municipal Water
and Power Plants until 5 o'clock
m. on the 19th day of AugUBt,
1912.
Proposals must be on blanks to
be furnished by tbe City of Palo
Alto and must be accompanied by
a "certified check on some solvent
bank In nn amount equal to 5 per
cent of tho hid, payable to the City
Clerk, ns a guarantee that contract
will be entered Into It proposal be
accepted.
Plans and specifications may be
secured at the office of the City
Clerk of tho City of Palo Alto.
The Board of Public Works reserves the right to reject nny and
all bids.
FRANK KASSON.
City Clerk.
Daled Palo Alto. July 30. 1912.
7-30-1 J3t
FIRE AWRM (TATIOXB.
. ;
0—W'»t**-rwork*.
i 12—Uni-iewlty aad Ramona.
! 1*—Everett aad Emersion.
; IB—rnlveraity awad High.
It—For-rwt and Emrrwin.
IS—Addison an*) Emrraon.
; 91—University and Waverley. ,
21!—lUwthorne and Wa*ierh*r/, J
■2T.—Hawthorne and Wee*s*tea*. j
27—Unlre-ralty and Webe*». ,
.1-2—Homer and Waverley.
84—KltiRsley and Wavetiey.
» B«—(I tanning and Webster.
8*—Ktng*Iey and Webster.
-tit—rnlverslty and Gulnde.
• 40—Univewtty and Hale.
i
Answer a want :.<'. and Investigate
•bat "opportunity** in person.
Ana we ring Her Father.
"Could yoo support my dnughlcr In
tha style to wblcb sbe ba* been accustomed f
■'1 hsve never tried soch rigid ceoi.
omy. air"- Life
Pbone 821. 828 1'nlren.itj Av.
Palo Alto Market
I*ur1(Uen A atonnlcfcaoB
Our Meats are the Best.
OUR PRICE IS RIGHT
UNITED STATES POSTOFFICE, PALO ALTO, OAL.—SCHEDULE OP
HAILS RECEIVED AND DISPATCHED.
In Effect Jane 0, 1012.
RECEIVED.
From— Due. Frequency.
San Jose «... 6:35 a.m. Dally
San Francisco and Santa Crus 6:58 a.m. Daily
San Frnnclsco, Mnyfleld, Santa Cruz.... 7;r>f, a.m. Dally oxcept Sunday
Stanford University 8:10 a.m. Dally oxcept Snnday
San Frnnclsco, San Joso and L. A 8:26 a.m. Dally
Stanford University 9:25 a.m. Sundays only
Stanford University 11:30 a.m. Dally except Sunday
San Francisco and Pacific Grove 11:98 a.m. Dally except Sunday
San Frnnclsco. San Jose and L. A 12:43 p.m. Dally oxcept Sunday
San Frnnclnco and Pacific Grove I;46 p.m. Dally except Sunday
Stanford University 3:00 p.m. Daily except Sunday
San Frnnclsco and Santa Cruz 3:01 p.m. Dally
San Franciaco, Mayfield. Santa Crus . f>:-|0 p.m. Dally except Sunday
Stanford University ". ... 6:15 p.m. Dally except Sunday
San Francisco, San Joso and L, A..... 6:16 p.m. Dally except Sunday
DISPATCHED.
To— t Close. Frequency.
San KrnnclHco and Snnta Crux 6:28 a.m. Dally
Stanford University 6:52 a.m. Dally
San Francisco, Mayfield, Santa Cruz.... 7:25 a.m. Dally except Sunday
San Francisco, San Jose and L. A 7:56 a.m. Sunday only
San Francisco and Psclflc Grove 11:05 a.m. Dally except Sunday
San Francisco. San Jobc and L. A 12:13 p.m. Dally except Sunday
Stanford University 12:13 p.m. Dally except Sunday
San Frnnclsco and Pacific Grove 2:15 p.m. Dally oxcopt Sunday
Snn Francisco and Santa Cruz. 2:31 p.m. Dally
Stanford University 2:31 p.m. Dally excopt Sunday
Stanford University 5:00 p.m. Dally except Sunday
San Francisco, Mayfield, Santa Cruz... 5:10 p.m. Dally except Sunday
Los Altos 5:40 p.m. Dally except Sunday
San FranclBco, San Jose and L, A.. ■. ■ *<:46 p.m. Dally except Sunday
C. H. DOBBEL, Postmaster.
Why You Take No Chances
The Studebaker name for sixty years
has been a guarantee of quality. It eliminates the slightest element of chance in
your purchase of an automobile.
Every part of a Studebaker car is
made in our own plants. We analyze and
absolutely know the materials which ro
into our cars. Our .guarantee is good.
75,000 Studebaker cars are on the
road and every owner will tell you that
a Studebaker car always makes good.
We know that the Studebaker
(Flanders) "20" at 800 is equal in material and workmanship to any car built—
and thc price is within jiour reach.
Ready for immediate delivery.;
Equlpr*. .
A*. ... .Mfar /or III. n*w 3lu..l.U, «,, r.l.r.t". .. ... J ,. .« *J. ** I
Tha Studebaker Corporation Detroit, Michi«aa»
Jordan & Walters Garage
Phone 241 524 High Stree
