1,286 research outputs found
The effects of Wnt5a and Wnt3a and PCP signaling on Schwann cell biology and myelination
No full textPlanar cell polarity (PCP) is known as the polarization of cells within the plane of the tissue layer. This form of polarization controls several epithelial and non-epithelial morphological processes, such as the orientation of primary cilia in the inner ear, convergent extension (CE) and directed migration. A three tiered model of PCP regulation has been proposed which consists of the global, core, and effector modules. However there is one addition level of modulation through non-canonical Wnt signaling pathway. Of the many Wnt proteins a few have been identified to signal primarily through this pathway. One such protein is Wnt5a, which has been shown to modulate PCP during directed cell migration. In this study we gather preliminary data for the presence of PCP signaling components in Schwann cells and investigate the effect of Wnt5a and its antagonist Wnt3a on Schwann cell proliferation, migration and myelination.M.S.Includes bibliographical referencesby Neha Jan
The effects of immediate versus delayed feedback after multiple-choice questions on subsequent exam performance
No full textThis thesis investigates the effects of immediate versus delayed feedback following multiple-choice questions on subsequent performance on multiple-choice and recall questions. In three experiments, students in a college psychology lecture course received immediate or delayed feedback following multiple-choice questions on an initial unit exam which was followed up with exam(s) including both multiple-choice and short-answer questions. In the first experiment, the kind of feedback did not affect performance on the same multiple-choice questions when they were repeated on the final. In the second experiment, two subsequent follow-up exams included first a short-answer version of the multiple-choice question and then the same multiple-choice question. Performance on the short-answer questions was better following delayed feedback than following immediate feedback. However, the kind of feedback had no effect on the performance of the repeated multiple-choice questions. Also, the interval between the initial exam and the follow-up exam had no effect on performance. The third experiment examined whether delayed feedback increased confidence more than immediate feedback and whether the increase in confidence mediated the improved performance on subsequent short-answer questions. The delayed feedback had no effect on confidence for the subsequent short-answer and multiple-choice responses. Together, these results demonstrate that delayed feedback improves performance on the short-answer questions by increasing the subsequent generation of the correct response but does not influence recognition of it.M.S.Includes bibliographical referencesIncludes vitaby Neha Sinh
Moral Panic, Social Exclusion and The Human Rights of Same-Sex Partners in Ghana-RETRACTED
No full textThis article is retracted :
The retraction is based on the request of the author, Dr. Neha Jain, as it contains some exclusive and private data of a community out of India, that should not be released online. https://doi.org/10.55938/ijgasr.v1i3.20
Sincerely,Editorial Team, IJGASR
Announcement: https://journals.icapsr.com/index.php/ijgasr/announcement/view/17
Longitudinal multi-omics analyses identify responses of megakaryocytes, erythroid cells and plasmablasts as hallmarks of severe COVID-19 trajectories . Bernardes et al
No full textSupplemental Tables for publication
Longitudinal multi-omics analysis identifies responses of megakaryocytes, erythroid cells and plasmablasts as hallmarks of severe COVID-19 trajectories
Joana P. Bernardes+, Neha Mishra+, Florian Tran+, Thomas Bahmer, Lena Best, Johanna I. Blase, Dora Bordoni, Jeanette Franzenburg, Ulf Geisen, Jonathan Josephs-Spaulding, Philipp Köhler, Axel Künstner, Elisa Rosati, Anna C. Aschenbrenner, Petra Bacher, Nathan Baran, Teide Boysen, Burkhard Brandt, Niklas Bruse, Jonathan Dörr, Andreas Dräger, Gunnar Elke, David Ellinghaus, Julia Fischer, Michael Forster, Andre Franke, Sören Franzenburg, Norbert Frey, Anette Friedrichs, Janina Fuß, Andreas Glück, Jacob Hamm, Finn Hinrichsen, Marc P. Hoeppner, Simon Imm, Ralf Junker, Sina Kaiser, Ying H. Kan, Rainer Knoll, Christoph Lange, Georg Laue, Clemens Lier, Matthias Lindner, Georgios Marinos, Robert Markewitz, Jacob Nattermann, Rainer Noth, Peter Pickkers, Klaus F. Rabe, Alina Renz, Christoph Röcken, Jan Rupp, Annika Schaffarzyk, Alexander Scheffold, Jonas Schulte-Schrepping, Domagoj Schunck, Dirk Skowasch, Thomas Ulas, Klaus-Peter Wandinger, Michael Wittig, Johannes Zimmermann, Hauke Busch*, Bimba F. Hoyer*, Christoph Kaleta*, Jan Heyckendorf*, Matthijs Kox*, Jan Rybniker*, Stefan Schreiber*, Joachim Schultze*, Philip Rosenstiel*, HCA Lung Biological Network and the Deutsche COVID-19 Omics Initiative (DeCOI)
+ Equal contribution first authors
* Senior authors
Table S1. Detailed clinical characteristics of the patients included in cohort1 (related to Figure 1)
Table S3. List of genes assigned to each co-expression module (related to figure 4
National political economy of climate funds: case studies of the PPCR and the SREP
No full textOver the last 20 years international climate finance has increased in scale, developed a complex architecture and drawn in a wide range of actors and institutions. Countries have made use of increasingly diverse sources of funding, financial instruments and intermediaries (Rai et al. 2015a; Kaur et al. 2014). Funding comes from both public and private sources, and may be channelled to developing countries in a variety of ways. These include funding mechanisms set up under the UNFCCC, as well as a range of multiand bilateral channels operating outside the UNFCCC (Rai et al. 2015b). At the same time, recent developments in climate policy are driving the integration of the mitigation and adaptation agendas. The increase in funds and diversification of funding mechanisms has ledto changes in priorities and power relations at the national level. The picture is complex, given the interaction between the general international context, with its influence on climate finance incentives and governance, and the specific political environments of individual countries. While analysis of the international context has been plentiful (see, for example, Paterson and Grubb 1992; Luterbacher and Sprinz 2001; Aldy et al. 2003; Adger et al. 2006; Nakhooda and Norman 2014), there is a need for greater attention to be paid to this interaction, and to ask how international initiatives are being translated and reformulated in national contexts (Tanner and Allouche 2011; Naess et al. 2015). In this chapter we address this question through case studies of the PilotProgram for Climate Resilience (PPCR) and the Scaling Up Renewable Energy Program (SREP) as they operate in Bangladesh, Ethiopia and Nepal. These two programmes represent global funding initiatives supporting the climate adaptation and climate mitigation agendas, respectively; both are part of the group of non-UNFCCC multilateral funds managed by the World Bank known as the Climate Investment Funds
sj-pdf-1-qhr-10.1177_10497323211036896 – Supplemental material for Body Image and Eating Disorders Among South Asian American Women: What Are We Missing?
No full textSupplemental material, sj-pdf-1-qhr-10.1177_10497323211036896 for Body Image and Eating Disorders Among South Asian American Women: What Are We Missing? by Neha J. Goel, Brogan Thomas, Rachel L. Boutté, Brahmpreet Kaur and Suzanne E. Mazzeo in Qualitative Health Research</p
Liquid-Liquid Phase Separation of Histone Proteins in Cells: Role in Chromatin Organization
No full text© 2019 Biophysical SocietyLiquid-liquid phase separation (LLPS) of proteins and nucleic acids has emerged as an important phenomenon in membraneless intracellular organization. We demonstrate that the linker histone H1 condenses into liquid-like droplets in the nuclei of HeLa cells. The droplets, observed during the interphase of the cell cycle, are colocalized with DNA-dense regions indicative of heterochromatin. In vitro, H1 readily undergoes LLPS with both DNA and nucleosomes of varying lengths but does not phase separate in the absence of DNA. The nucleosome core particle maintains its structural integrity inside the droplets, as demonstrated by FRET. Unexpectedly, H2A also forms droplets in the presence of DNA and nucleosomes in vitro, whereas the other core histones precipitate. The phase diagram of H1 with nucleosomes is invariant to the nucleosome length at physiological salt concentration, indicating that H1 is capable of partitioning large segments of DNA into liquid-like droplets. Of the proteins tested (H1, core histones, and the heterochromatin protein HP1α), this property is unique to H1. In addition, free nucleotides promote droplet formation of H1 nucleosome in a nucleotide-dependent manner, with droplet formation being most favorable with ATP. Although LLPS of HP1α is known to contribute to the organization of heterochromatin, our results indicate that H1 also plays a role. Based on our study, we propose that H1 and DNA act as scaffolds for phase-separated heterochromatin domain
Correction to: A cell-cycle signature classifier for pan-cancer analysis
No full textIn the original published version, the list of authors was incomplete. Theodora A. Constantin was missing, and Neha Tabassum and Theodora A. Constantin share first authorship. The correct author list is given above. The original article has been corrected. DOI to original article: https://doi.org/10.1038/s41388-020-01426-
Less-institutionalized social structures: a theoretical, methodological, and empirical analysis of how networks and culture matter for emergence
No full textUsing a networks and culture lens, I investigate the micro-level processes underlying the production of order in social contexts or locations that are relationally-defined and meaningful, but lack cultural cues to action and interpretation or are in the early stages of acquiring such meaning. Drawing on neoinstitutionalist theory, I refer to such social structures as less-institutionalized. To explain order in the absence of situational cultural cues literature in social network analysis has traditionally attributed regularities to situational structural tendencies that preclude shared understandings and/or subjective engagement. Recent literature in the sociology of culture that revives overarching moral intuitions as a basis for action similarly rejects the explanatory value of situational cultural cues. Arguing that culture is neither irrelevant nor implicated in an overarching way in culturally less-institutionalized situations, I posit that order can be linked to individuals’ tacit and discursive use of cultural repertoires acquired over the life-course through involvements in multiple networks of interaction and domains of shared meanings or ‘netdoms.’ I analytically distinguish between three categories of less-institutionalized situations of the basis of the degree of uncertainty in interpretation and action they impose upon their occupants: high, intermediate, and absence/low. I demonstrate my argument using three examples of less-institutionalized situations/positions from distinct sociological fields: (1) rapid labor-force feminization in South Asia (high-uncertainty); (2) an emergent area of knowledge production (intermediate-uncertainty); and (3) falling average sibship-size implicated in worldwide fertility decline (low/absent uncertainty). Elaborating upon three cross-netdom mechanisms - analogizing, contrasting, and spillovers – and using a mixture of interpretive techniques, multilevel statistical models, and exponential random graph models, I show that occupants use cultural repertoires discursively in high-uncertainty less-institutionalized positions, tacitly in low-uncertainty situations, and in a combination of tacit and deliberative ways under conditions of intermediate uncertainty. I also develop a mathematical model to show how less-institutionalized practices/interpretations can come to be institutionalized over time through management of uncertainty within homophilous networks. Lastly, positing a duality between the cultural repertoires of individuals and those of social locations, I conclude with a discussion on how less-institutionalized positions offer a unique window into investigating processes of emergence and social change.Ph. D.Includes bibliographical referencesIncludes vitaby Neha Gonda
The sleep–circadian connection: pathways to understanding and supporting autistic children and adolescents and those with attention-deficit hyperactivity disorder
No full textAutism and attention-deficit hyperactivity disorder (ADHD) are among the most common neurodivergent neurotypes worldwide. Epidemiological evidence shows that sleep and circadian disturbances, such as difficulty initiating and maintaining sleep, and delayed sleep–wake phase, are highly prevalent in autistic children, children with ADHD, and those with both neurotypes. Despite scientific advancements, a comprehensive framework integrating sleep and circadian mechanisms with targeted interventions for autism and ADHD remains underdeveloped. In this Review we examine sleep and circadian rhythm differences in autistic children and adolescents, and in those with ADHD or both neurotypes, focusing on the underlying biological mechanisms. We discuss recent advances in the genetic and molecular links between sleep, circadian rhythms, and neuroplasticity, alongside the influence of these systems on physiology and therapeutic strategies. Both pharmacological and non-pharmacological interventions are considered, with an emphasis on the need for an integrated support model that accounts for the dynamic interplay between sleep and circadian rhythms in these populations. We identify key gaps in the current evidence base, particularly in relation to non-pharmacological interventions, and outline future research directions. Although most randomised controlled trials in children and adolescents have focused on behavioural sleep interventions, we also discuss emerging findings from trials using alternative approaches, such as targeted light therapy in adults, with implications for paediatric populations. Finally, we emphasise the importance of incorporating the perspectives of autistic children and adolescents and those with ADHD, as well as their parents and caregivers, into research designs.</p
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