1,721,036 research outputs found
How chemokines invite leukocytes to dance
No full textA prominent activity of the chemokine system is the regulation of leukocyte trafficking. Here we summarize recent findings on the initial steps in chemokine receptor-induced signal transduction in leukocytes. In particular, we discuss the potential influences of the formation of oligomers of ligand and receptor and of coupling between chemokine signals and regulators of the cytoskeleton, such as small GTPases
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Fosforilação da HsPI3-Kinase-C2α = Phosphorylation of HsPI3-Kinase-C2α
No full textMestrado em Métodos Biomoleculares AvançadosVárias isoformas da enzima fosfoinositide-3-cinase (PI3-Cinase), uma vasta
família de cinases lipidicas têm nos últimos anos vindo a ser clonada e
caracterizada. P13-Cinases constituem uma família de cinases conservadas
durante a evolução que catalisam a adição de uma molécula de fosfato ao
fosfatidilinositol e seus derivados, esta adição tem lugar no anel inositol na
posição D3. P13-Cinases estão agrupadas em três classes de acordo com as
moléculas que preferencialmente utilizam como substrato in vitro e de acordo
com as suas características estruturais.
Fosfoinositide-3-Cinase-C2α (PI3-Cinase-C2α), pertence à classe I1 de P13-
Cinases, esta classe é caracterizada pela utilização de fosfatidilinositol e
fosfatidilinositol-4-P como substrato in vitro. Todos os membros da classes I1
possuem no seu C-terminal um domínio C2, característico da classe.
Este trabalho permitiu a identificação do local de fosforilação da HsPI3-Cinase-
C2α bem como a identificação de duas cinases envolvidas na sua fosforilação.
A fosforilação de HsP13-Kinase-C2α ocorre na Ser259 e este resíduo é um alvo
comum de fosforilação mitótica e de fosforilação induzida por radiação UV.
Durante o ciclo celular HsP13-Cinase-C2α é predominantemente fosforilada na M fase e a cinase envolvida 6 a Cdk1,após radiação UV a fosforilação é
mediada pela JNK.In recent years, a large family of Phosphoinositide-3-Kinases (PI3-Kinase)
isozymes has been characterized and cloned. PI3-Kinases constitute a family
of evolutionary conserved lipid kinases that catalyse the addition of a
phosphate molecule to the D3 position of the inositol ring of
phosphatidylinositol and its derivatives. P13-Kinases are grouped into three
classes according to the molecules that they preferentially utilize as substrates
and their structural characteristics.
Phosphoinositide-3-Kinase-C2α (P13-Kinase-C2α) belongs to class II P13-
Kinases, which are defined by their in vitro use of phosphatidylinositol and
phosphatidylinositol-4-phosphate as substrates. All type II P13-Kinases contain
a C2 domain at their C-terminus.
This work resulted in the identification of a phosphorylation site on HsP13-
Kinase-C2α as well the identification of two kinases involved in mitotic and UVinduced
phosphorylation of HsP13-Kinase-C2α. The phosphorylation of HsP13-
Kinase-C2α occurs in Ser259 and this serine is a common target in mitotic and
UV-induced phosphorylation. We found that during the cell cycle HsP13-
Kinase-C2α is predominantly phosphorylated in mitotic phase and the kinase
involved is Cdkl and after UV irradiation the phosphorylation of HsPI3-Kinase-
C2α is mediated by JNK
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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