3,034 research outputs found
aE Journal 2015/2016: aE/INTECTURE innovating architecture
No full textThe graduation studio of Architectural Engineering focuses on the integration of (new) technology in architecture. For this purpose, the name aE/ INTECTURE® was devised, which will be developed further as a brand in the coming years. Students start with a technical fascination and translate this into an architectural concept, finally being able to implement this within the environment in a responsible way. ‘If technology is the answer, what is the question?‘ Under the guidance of a team of enthusiastic (guest) lecturers, students search for the dot on the horizon that is necessary for coming up with solutions that improve the quality of the built environment and make it more sustainable. In addition, either the ‘making‘ (make) or ‘the energy and material flow’ (flow) is used and applied as a basis in different contexts.Architectural Engineerin
Genome-wide DNA methylation analysis for diabetic nephropathy in type 1 diabetes mellitus
No full textBACKGROUND: Diabetic nephropathy is a serious complication of diabetes mellitus and is associated with considerable morbidity and high mortality. There is increasing evidence to suggest that dysregulation of the epigenome is involved in diabetic nephropathy. We assessed whether epigenetic modification of DNA methylation is associated with diabetic nephropathy in a case-control study of 192 Irish patients with type 1 diabetes mellitus (T1D). Cases had T1D and nephropathy whereas controls had T1D but no evidence of renal disease. METHODS: We performed DNA methylation profiling in bisulphite converted DNA from cases and controls using the recently developed Illumina Infinium(R) HumanMethylation27 BeadChip, that enables the direct investigation of 27,578 individual cytosines at CpG loci throughout the genome, which are focused on the promoter regions of 14,495 genes. RESULTS: Singular Value Decomposition (SVD) analysis indicated that significant components of DNA methylation variation correlated with patient age, time to onset of diabetic nephropathy, and sex. Adjusting for confounding factors using multivariate Cox-regression analyses, and with a false discovery rate (FDR) of 0.05, we observed 19 CpG sites that demonstrated correlations with time to development of diabetic nephropathy. Of note, this included one CpG site located 18 bp upstream of the transcription start site of UNC13B, a gene in which the first intronic SNP rs13293564 has recently been reported to be associated with diabetic nephropathy. CONCLUSION: This high throughput platform was able to successfully interrogate the methylation state of individual cytosines and identified 19 prospective CpG sites associated with risk of diabetic nephropathy. These differences in DNA methylation are worthy of further follow-up in replication studies using larger cohorts of diabetic patients with and without nephropathy
Code for the mQTL analyses in 2023 Nature Genetics
No full textCitation:
Analysis of blood methylation quantitative trait loci in East Asians identifies ancestry-specific effects associated with complex trait variation.
Qianqian Peng, Xinxuan Liu, Wenran Li, Han Jing, Jiarui Li, Xingjian Gao, Qi Luo, Charles E. Breeze, Siyu Pan, Qiwen Zheng, Guochao Li, Jiaqiang Qian, Liyun Yuan, Na Yuan, Chenglong You, Siyuan Du, Yuanting Zheng, Ziyu Yuan, Jingze Tan, Peilin Jia, Jiucun Wang, Guoqing Zhang, Xianping Lu, Leming Shi, Shicheng Guo, Yun Liu, Ting Ni, Bo Wen, Changqing Zeng, Li Jin, Andrew E. Teschendorff, Fan Liu, Sijia Wang
aE Journal 2017/2018: aE/Intecture innovating architecture
No full textDriven by the need to think differently about resources, energy, power generation, the choice of materials, and user involvement, we see the built environment in a new perspective. The program, Architectural Engineering, seeks for innovative and inspiring architectural solutions for social and environmental issues throughout all scales.To achieve this, innovation of the architectural challenge is high on our agenda. Innovation is more than just a technical improvement. How do you implement new current issues in modern architecture? We anticipate new energy, materials, and circularity. We also use the current environment of the metropolis and the countryside. We add new buildings, strengthen existing stock, and work on new components of buildings. From high to low tech. From digital to traditional, looking carefully to the context.Architectural Engineerin
Main motifs in the prose of the leftist author Kang Kyŏng-ae
No full textThe subject of this bachelor thesis is the life and work of the Korean writer Kang Kyǒng-ae, with a focus on her short prose. The aim of this thesis is an analysis of two works - Salt and Darkness - with attention to the context of the author's time. Nowadays, Kang Kyǒng-ae is considered a significant author of the 1930s and her works reflect the phenomenon of Korean emigrants in Manchuria. For a long time, leftist tendencies caused her prose to be neglected, which resulted in a considerably limited number of studies concerned with her work, in comparison to the number of studies about other writers. There are virtually no Czech studies of her work. The text of the thesis initially presents the timeframe of Kang's authorship and then analyzes select works of hers. The analysis of the works focuses on recurring motifs, which are put into a historical and social context. Keywords Kang Kyǒng-ae, Korean 1930s literature, leftist literature, Sogǔm, Ǒdu
Epigenetic clocks galore: a new improved clock predicts age-acceleration in Hutchinson Gilford Progeria Syndrome patients
No full textComment on: “Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies” by Steve Horvath, et al. published in Aging Volume 10, Issue 7, pp 1758—75. http://www.aging-us.com/article/101508/tex
Biographical Romance, or The Wonders of ihe Life of An Émigrée of Choice: Fryderyk Járosy (1889–1960) – the Author of Unwritten Memoirs of Life Among the Polish Diaspora in London
No full textEnglish version. Original issue: “Archiwum Emigracji” 2009, no. 1 (10)https://apcz.umk.pl/AE/article/view/AE.2009.01
Epigenetic and genetic deregulation in cancer target distinct signaling pathway domains
No full textCancer is characterized by both genetic and epigenetic alterations. While cancer driver mutations and copy-number alterations have been studied at a systems-level, relatively little is known about the systems-level patterns exhibited by their epigenetic counterparts. Here we perform a pan-cancer wide systems-level analysis, mapping candidate cancer-driver DNA methylation (DNAm) alterations onto a human interactome. We demonstrate that functional DNAm alterations in cancer tend to map to nodes of lower connectivity and inter-connectivity, compared to the corresponding alterations at the genomic level. We find that epigenetic alterations are relatively over-represented in extracellular and transmembrane signaling domains, whereas cancer genes undergoing amplification or deletion tend to be enriched within the intracellular domain. A pan-cancer wide meta-analysis identifies WNT and chemokine signaling, as two key pathways where epigenetic deregulation preferentially targets extracellular components. We further pinpoint specific chemokine ligands/receptors whose epigenetic deregulation associates with key epigenetic enzymes, representing potential targets for epigenetic therapy. Our results suggest that epigenetic deregulation in cancer not only targets tissue-specific transcription factors, but also modulates signaling within the extra-cellular domain, providing novel system-level insight into the potential distinctive role of genetic and epigenetic alterations in cancer
Autour du Nepos d'Alburnus, Maior, Panes, fils de Bizo (AE, 20081167=AE, 2007, 1201) : petit-fils ou neveu
No full textInternational audienceIn this article, the author studies again the inscription on a stone of a nepos from Alburnus Maior: Panes, son of Bizo (AE, 2008, 1167 = AE,2007, 1201). If the word nepos very often means « grandson », there are cases where it means « nephew ». The author pays special attention to the Latin kinship terminology in this inscription because names and lines are not Roman but peregrine. So, there is ambiguity as we cannot exactly know the relations between all these names. Now, between a grandfather and his grandson or an uncle and his nephew, there is the same number of generations. It is necessary for one to compare these to other inscriptions and words in addition to nepos (auia, auus, nurus, gener, pater, mater) or only with nepos in Rhenodanubian provinces (Raetia, Pannoniae, Moesiae, Dacia): these 67 inscriptions are in an appendix.The author concludes that the these two possibilities exist here
Cell-type deconvolution in epigenome-wide association studies: a review and recommendations
No full textA major challenge faced by epigenome-wide association studies (EWAS) is cell-type heterogeneity. As many EWAS have already demonstrated, adjusting for changes in cell-type composition can be critical when analyzing and interpreting findings from such studies. Because of their importance, a great number of different statistical algorithms, which adjust for cell-type composition, have been proposed. Some of the methods are ‘reference based’ in that they require a priori defined reference DNA methylation profiles of cell types that are present in the tissue of interest, while other algorithms are ‘reference free.’ At present, however, it is unclear how best to adjust for cell-type heterogeneity, as this may also largely depend on the type of tissue and phenotype being considered. Here, we provide a critical review of the major existing algorithms for correcting cell-type composition in the context of Illumina Infinium Methylation Beadarrays, with the aim of providing useful recommendations to the EWAS community
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