1,685 research outputs found
Luisa Igloria, 36th Annual ODU Literary Festival
No full textLuisa Igloria is an award -winning poet, and the author of The Saints of Streets (University of Santo Tomas Publishing House, Fall 2013), Juan Luna\u27s Revolver (University of Notre Dame Press, 2009 Ernest Sandeen Prize), Trill & Mordent (WordTech Editions, 2005), and 8 other books. Luisa has degrees from the University of the Philippines, Ateneo de Manila University, and the University of Illinois at Chicago, where she was a Fulbright Fellow from 1992-1995. Luisa teaches in and currently directs the MFA Creative Writing Program at Old Dominion University
Luisa A, Igloria, 37th Annual ODU Literary Festival
No full textLUISA A. IGLORIA is a professor and director of the MFA Creative Writing Program at ODU. She is the author of Ode to the Heart Smaller than a Pencil Eraser (2014 May Swenson Prize, University of Utah Press); Night Willow: Prose Poems (2014); The Saints of Streets (2013); Juan Luna\u27s Revolver (2009 Ernest Sandeen Prize); Trill & Mordent (2005); and eight other books. Luisa was a Fulbright Fellow from 1992-95 at the University of Illinois at Chicago. Since Nov. 20, 2010, she has written (at least) a poem a day, archived at www.vianegativa.us/author/luisa/
Luisa Igloria, 28th Annual ODU Literary Festival
No full textLuisa Igloria (previously published as Maria Luisa A. Carino) is the author of six books, four of which received the National Book Award from the Manila Critics’ Circle: Blood Sacrifice (University of the Philippines Press, 1998); Encanto (Anvil, 1994); Cartography (Anvil, 1992); and Cordillera Tales (New Day, 1990). She is also the author of In the Garden of the Three Islands (Moyer Bell/Asphodel, 1995), and the editor of Not Home, But Here: Writing from the Filipino Diaspora (Anvil, 2003). Her seventh and most recent book is Trill & Mordent (WordTech Editions, 2005), a runner-up for the 2004 Editions Prize. Igloria’s work has appeared in numerous national and international journals; she has received prestigious honors that include the 2004 Fugue Poetry Award, Finalist for the 2004 Larry Levis Editors Prize for Poetry, and Finalist for the 2003 Dorset Prize (Tupelo Press). She has received fellowships from the Fulbright Foundation, the Hawthornden Castle in Scotland, and to the Summer Literary Seminars in St. Petersburg, Russia. Igloria is an associate professor on the faculty of ODU’s Creative Writing Program
Luisa A. Igloria, 43rd Annual Literary Festival
No full textLuisa A. Igloria was recently appointed Virginia Poet Laureate (2020-2022). She is the 2019 co-winner of the Crab Orchard Open Poetry competition for Maps for Migrants and Ghosts (Fall 2020) and winner of the 2015 Resurgence Prize (U.K.), the world\u27s first major award for ecopoetry. She is the author of four chapbooks plus 14 full-length works, including The Buddha Wonders if She is Having a Mid-Life Crisis (2018), Ode to the Heart Smaller than a Pencil Eraser (2014 May Swenson Prize), and Juan Luna\u27s Revolver (2009 Ernest Sandeen Prize). She teaches in ODU\u27s MFA Program in Creative Writing
In vivo hypoxia and prostate cancer growth
No full textBackground. Solid tumors require a local vascular network that supplies O2 and nutrients for their growth. When cell proliferation exceeds angiogenesis, vasculature might become unable to sustain the O2 needs of tumors. The resulting limitation in O2 supply causes tumors to cope with an environment chronically deficient in O2 (chronic hypoxia, CH). Local over-expression of hypoxia inducible factor 1α (HIF-1α) transactivates compensatory mechanisms aimed at survival, including the angiogenic switch, which provides growth factors for the development of circulation to feed the growing tumor. However, the newly formed vessels are more twisted, tortuous, distorted and irregular than mature vessels, which leads to inefficient and irregular, perhaps pulsing oxygenation. The resulting situation resembles a paradigm whereby CH is interspersed with various reoxygenation events (CHReox). Although hypoxia is known to increase tumor aggressiveness, resistance to radiotherapy, malignant progression and enhanced metastases formation, it remains to be established if the signaling path originating from systemic hypoxia can exacerbate tumorigenesis.
Aims. Two are the aims of this thesis. First, testing the hypothesis that systemic hypoxia in vivo up-regulates prostate cancer growth. Second, to get a better insight into the role of HIF-1α, testing a condition whereby HIF-1α expression is perturbed to enable distinguishing the effects due to hypoxia from those due to HIF-1α. To this purpose, CHReox was selected as a non-pharmacological approach to alter HIF-1α expression without use of drugs and substances that may mask the results.
Methods. Male athymic nu/nu mice were xenografted with LNCaP cells and exposed for 4 weeks to either CH (10% O2) or CHReox (3 reoxygenation/week for 1 h), with normoxic mice as control.
Results. Tumors grew faster in hypoxia than in normoxia, in agreement with higher phosphorylation rate of protein kinase B (Akt), an inhibitor of apoptosis and inducer of cell proliferation. Tumor Hb content was higher in hypoxia than in normoxia, reflecting the higher blood Hb content rather than increased vascularization, in agreement with similar tissue level of VEGF, a mediator of angiogenesis. Although CH and CHReox induced similar patterns of these parameters, expression level of HIF-1α, assessed by Western blot and immunohistochemistry, was markedly higher for CHReox than CH. The inflammatory infiltrate in the tumor mass was less in hypoxia than in normoxia, in the favour of greater mass of tumor cells in hypoxia. However, although the inflammatory infiltrate displayed relevant characteristics of apoptosis, tumor cells were scarcely apoptotic.
Conclusion. Systemic hypoxia in vivo increases the rate of prostate LNCaP tumor growth in athymic nude mice, irrespectively of CH or CHReox. Such effect is influenced neither by tumor vascularization nor by VEGF. As HIF-1α expression levels are markedly different in the two hypoxic conditions, yet the tumor growth rate is essentially the same, it appears that in the tested in vivo model the HIF-1α-linked pathways are less prominent that those linked to the PI3K/Akt pathwa
Luisa González
No full textThis is a testimonial of the representation of the play entitled A ras del suelo, by Luisa González. This deals with the initial encounter with the author, her knowledge and the begin- ning of a wonderful and enriching friendship among Luisa González and the Costa Rican actress Eugenia Cheverri.Es un testimonio de la génesis de la puesta en escena de la obra “A ras del suelo” de Luisa González. El encuentro inicial, físico con ella, su participación como autora, y el inicio de una hermosa amistad entre la escritora del relato y la gente de teatro costarricense en los años setenta
Luisa Igloria, 41st Annual ODU Literary Festival
No full textLuisa A. Igloria is the winner of the 2015 ResurgencePrize (UK), the world\u27s first major award for ecopoetry, selected by former UK poet laureate Sir Andrew Motion, Alice Oswald, and Jo Shapcott. She is the author of three chapbooks plus the full length works The Buddha Wonders if She is Having a Mid-Life Crisis (Phoenicia Publishing, Montreal; March 2018), Ode to the Heart Smaller than a Pencil Eraser (selected by Mark Doty for the 2014 May Swenson Prize, Utah State University Press), Night Willow (Phoenicia Publishing, Montreal, 2014),The Saints of Streets (University of Santo Tomas Publishing House, 2013), Juan Luna\u27s Revolver (2009 Ernest Sandeen Prize, University of Notre Dame Press), and nine other books. She teaches on the faculty of the MFA Creative Writing Program at Old Dominion University, which she directed from 2009-2015
Luisa A. Igloria: 47th Annual ODU Literary Festival
No full textLuisa A. Igloria is the author of Caulbearer (Immigrant Writing Series Prize, Black Lawrence Press, 2024), Maps for Migrants and Ghosts (Co-Winner, 2019 Crab Orchard Open Poetry Prize), The Buddha Wonders if She is Having a Mid-Life Crisis (2018), 12 other books, and 4 chapbooks. With Aileen Cassinetto and Jeremy S. Hoffman, she co-edited Dear Human at the Edge of Time: Poems on Climate Change in the U.S. (Paloma Press, 2023), offered as a companion to the Fifth National Climate Assessment (NCA5). Originally from Baguio City, she makes her home in Norfolk VA where she is the Louis I. Jaffe and University Professor of English and Creative Writing at Old Dominion University’s MFA Creative Writing Program. She also leads workshops for and is a member of the board of The Muse Writers Center in Norfolk. Luisa is the 20th Poet Laureate of the Commonwealth of Virginia (2020-22), Emerita. During her term, the Academy of American Poets awarded her a 2021 Poet Laureate Fellowship
Structural insights on the role of halogen bonding in protein MEK kinase-inhibitor complexes
No full textKinases are enzymes that play a critical role in governingessential biological processes. Due to their pivotal involvementin cancer cell signaling, they have become key targets in thedevelopment of anti-cancer drugs. Among these drugs, thosecontaining the 2,4-dihalophenyl moiety demonstrated signifi-cant potential. Here we show how this moiety, particularly the2-fluoro-4-iodophenyl one, is crucial for the structural stabilityof the formed drug-enzyme complexes. Crystallographic analy-sis of reported kinase-inhibitor complex structures highlightsthe role of the halogen bonding that this moiety forms withspecific residues of the kinase binding site. This interaction isnot limited to FDA-approved MEK inhibitors, but it is alsorelevant for other kinase inhibitors, indicating its broadrelevance in the design of this class of drug
Diva Carmen Luisa Letelier Valdés, contralto
No full textCarmen Luisa Letelier Valdés y Valene Georges son fundadoras del célebre Ensemble Bartok Chile. En este trabajo Valene Georges presenta un recuerdo tanto de los titánicos logros que ambas han alcanzado con el Ensemble Bartok Chile en el país como en el extranjero, como de la estrecha amistad que las ha unido durante más de treinta años.Both Carmen Luisa Letelier-Valdés and Valene Georgesfounded the renowned Ensemble Bartok Chile. In this article Valene Georges presents a retrospective view ofthe titanic achievements that both have shared with this ensemble in Chile and abroad. Besides, the author presents a personal view ofher close friendship with Carmen Luisa during more than thirty years
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