32,142 research outputs found
William Tarn, Hellenistic Civilisation. Third Edition revised by the Author and G. T. Griffith
No full textNachtergael Georges. William Tarn, Hellenistic Civilisation. Third Edition revised by the Author and G. T. Griffith. In: L'antiquité classique, Tome 44, fasc. 2, 1975. p. 782
William Tarn, Hellenistic Civilisation. Third Edition revised by the Author and G. T. Griffith
No full textNachtergael Georges. William Tarn, Hellenistic Civilisation. Third Edition revised by the Author and G. T. Griffith. In: L'antiquité classique, Tome 44, fasc. 2, 1975. p. 782
Selective tumor cell death induced by irradiated riboflavin through recognizing DNA G-T mismatch
No full textRiboflavin (vitamin B2) has been thought to be a promising antitumoral agent in photodynamic therapy, though the further application of the method was limited by the unclear molecular mechanism. Our work reveals that riboflavin was able to recognize G-T mismatch specifically and induce singlestrand breaks in duplex DNA targets efficiently under irradiation. In the presence of riboflavin, the photo-irradiation could induce the death of tumor cells that are defective in mismatch repair system selectively, highlighting the G-T mismatch as potential drug target for tumor cells. Moreover, riboflavin is a promising leading compound for further drug design due to its inherent specific recognition of the G-T mismatch
f(G,T) and its Cosmological Implications
No full textA coupled formulation of the Gauss-Bonnet invariant term G and the
energy momentum trace T term provide a modified f(G,T) gravity,
has been analyzed in this study. The functional form for the
f(G,T) gravity has been taken as f(G,T)=αT+ βGThe presentation of the authors' names and (or) special characters in the title of the pdf file of the accepted manuscript may differ slightly from what is displayed on the item page. The information in the pdf file of the accepted manuscript reflects the original submission by the author
Identification of Immune Gene Signature Associated with T Cells and Natural Killer Cells in Type 1 Diabetes [Corrigendum]
No full textWang N, Wang G, Feng X, Yang T. Diabetes Metab Syndr Obes. 2024;17:2983—2996.
The authors have advised the affiliation callouts in the author list on page 2983 are incorrect. The correct author callouts should read as follows:
Na Wang1, Guofeng Wang1,2, Xiuli Feng1, Teng Yang
Selection of HIV-specific immunogenic epitopes by screening random peptide libraries with HIV-1-positive sera
No full textEfforts to develop a protective HIV-1 vaccine have been hindered by difficulties in identifying epitopes capable of inducing broad neutralizing Ab responses. In fact, the high mutation rate occurring in HIV-1 envelope proteins and the complex structure of gp120 as an oligomer associated with gp41 result in a high degree of antigenic polymorphism. To overcome these obstacles, we screened random peptide libraries using sera from HIV-infected subjects to identify antigenic and immunogenic mimics of HIV-1 epitopes. After extensive counterscreening with HIV-negative sera, we isolated peptides specifically recognized by Abs from HIV-1-infected individuals. These peptides behaved as antigenic mimics of linear or conformational HIV-1 epitopes generated in vivo in infected subjects. Consistent with these findings, sera of simian HIV-infected monkeys also recognized the HIV-specific epitopes. The selected peptides were immunogenic in mice, where they elicited HIV-specific Abs that effectively neutralized HIV-1 isolates. These results demonstrate that pools of HIV-1 mimotopes can be selected from combinatorial peptide libraries by taking advantage of the HIV-specific Ab repertoire induced by the natural infection
Elaboration on Kwapien's theorem: Representing bounded mean zero functions f as coboundary f = g ◦ T − g
No full textIn [8] Kwapien proved that every mean zero function f ∈ L∞[0, 1] we can write as f = g ◦ T − g for some g ∈ L∞[0, 1] and some measure preserving transformation T of [0, 1]. However, as was discovered in [4] there is a gap in the proof for the case that f is not continuous. The aim of this bachelor thesis is filling in that gap in the proof. We first extend Kwapien’s proof for continuous functions to certain other measure spaces. Thereafter, we use the method of proof suggested by Kwapien, to proof the theorem for mean zero function f ∈ L∞[0, 1] for which λ(f−1({x})) = 0 for all x ∈ R. Using this result we then proof that every mean zero function f ∈ L∞[0, 1] can be written as a sum f =(g1 ◦ T1 − g1) + (g2 ◦ T2 − g2) where g1, g2 ∈ L∞[0, 1] and where T1, T2 are measure preserving transformations of [0, 1]. We finish this thesis with an application of Kwapien’s theorem in the study to singular traces Applied Mathematic
Lost in Translation. About the Castilian Gloss on Giles of Rome’s De regimine principum
No full textThe paper shows how deep are the changes that Giles of Rome's de regimine principum undergoes in the so-called Castilian Gloss. the traditional attibution to the Franciscan friar Juan Garcia de Castrojeriz has been challenged. The paper claims, however, on internal evidence, that the author must have been a Franciscan friar. The book is edited by G. Briguglia and T. Ricklin
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
No full textIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
- …
