1,721,036 research outputs found
Breast Cancer Derived Extracellular Vesicles in Bone Metastasis Induction and Their Clinical Implications as Biomarkers
Full text linkCancer incidence and mortality are rapidly growing worldwide. The main risk factors for cancer can be associated with aging as well as the growth of the population and socioeconomic condition. Breast cancer, a crucial public health problem, is the second cause of death among women. About 70% of patients with advanced breast cancer have bone metastases. In bone metastasis, cancer cells and osteoclasts form a vicious cycle: cancer cells promote osteoclast differentiation and activation that, in turn, induce cancer cell seeding and proliferation in the bone. Growing evidence shows that extracellular vesicles (EVs) play a key role in carcinogenesis, proliferation, pre-metastatic niche formation, angiogenesis, metastasis, and chemoresistance in several tumors, such as breast, lung, prostate, and liver cancer. Here, we discuss the role of EVs released by breast cancer cells, focusing on bone metastasis induction and their clinical implications as biomarkers
Role of miRNAs shuttled by exosomes in the crosstalk between chronic myelogenus leukemia and endothelial cells.
No full textExosomes released by K562 chronic myeloid leukemia cells promote angiogenesis in a Src-dependent fashion.
No full textRole of exosomes released by colon cancer stem cells in the modulation of tumor microenvironment
No full textContribution of proteomics to understanding the role of tumor-derived exosomes in cancer progression: State of the art and new perspectives
Full text linkExosomes are nanometer-sized vesicles (40–100 nm diameter) of endocytic origin released
from different cell types under both normal and pathological conditions. They function as cell
free messengers, playing a relevant role in the cell–cell communication that is strongly related
to the nature of the molecules (proteins, mRNAs, miRNAs, and lipids) that they transport.
Tumor cells actively shed exosomes into their surrounding microenvironment and growing
evidence indicates that these vesicles have pleiotropic functions in the regulation of tumor
progression, promoting immune escape, tumor invasion, neovascularization, and metastasis.
During the last few years remarkable efforts have been made to obtain an accurate definition
of the protein content of tumor-derived exosomes (TDEs) by applying MS-based proteomic
technologies. To date, TDEs proteomic studies have been mainly utilized to catalog TDEs
proteins with the purpose of identifying disease biomarkers. The future challenge for improving
our understanding and characterization of TDEs will be the implementation of new systemsdriven
and proteomic integrative strategies. The aim of this article is to provide an overview of
the most characterized exosomes-mediated mechanisms that contribute to the pathogenesis of
cancer and to review recent proteomics data that support the protumorigenic role of TDEs
Additional file 6: of SWATH-MS based quantitative proteomics analysis reveals that curcumin alters the metabolic enzyme profile of CML cells by affecting the activity of miR-22/IPO7/HIF-1Îą axis
Full text linkTable S3. DownReg Proteins_FunRichGOterms. (XLSX 50 kb
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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