1,720,959 research outputs found
The immunolocalization of ALL-1/MLL/HRX and AF-4 antigens in resting and leukaemic mononuclear cells
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Laboratory work-up for a complete molecular diagnosis on all patients; experience of the U.O Ematologia “A. Businco”, Cagliari
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Internal tandem duplication, d835 mutation in acute myeloid and promielocitic leukemia
No full textIntroduction. Biological characteristics and prognostic values
of FMS-like kinasi 3 (FLT3) gene dislocated on 13q12
were studied. This protein is employed in staminal and B
cell differentiation. Mutations of FLT3 are present in 35-
40% of patients with acute myeloid leukaemia. These
genetic alterations consist of “Internal tandem duplications”
(ITDs) and substitution of aspartic acid (Asp) in the 835
positions. Aims of study The aim of this study was to individuate
a diagnostic method for FLT3/ITDs and D835
mutation.
Materials and methods. From January 2004, 34 consecutive
cases with de novo Acute Myeloid Leukemia (AML) have
been studied. Median age was 50 years (range 25 – 80).
Twenty-three case were male and 11 female. Two PCR
methods have been used for FLT3/ITDs and one for D835
mutations. Mixed lineage leukemia gene (MLL) study and
t(9,22)p190, t(9,22)p210, t(8;21), t(4;11) translocations
analyses have been performed. Study of sequence gene
were made in Leukaemia Frankfurt Institute. Were utilised
a set of new primers dislocated between 10/11 and 12/13
exons of FLT3 gene
Results. In 11/34 (34,4%) cases, FLT3/ITDs transcripts
were positives by RT-PCR. In only two cases, FLT3/ITDs
positives was confirmed with sequence analysis. In 2/11
positive cases (18,1%) were revealed base substitutions butnot specific mutations in FLT3 gene. MLL studies and specific
AML translocations were negative on all cases. D835
mutations by exon 17 were positives on 2 cases (5,8%).
Conclusions The new primers set, for exon 11/12; 12/13 in
FLT3/ITDs gene, had given results confirmed by sequence
analysi
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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