1,720,967 research outputs found
HIV-1 Tat e iL monocita/macrofago: dall'interazione cellula/proteina all'insorgenza delle patologie associate all'AIDS
No full textMechanisms of WHIM syndrome
No full textWHIM syndrome is a genetically inherited disease that is characterized by chronic neutropenia, myelokathexis, hypogammaglobulinemia, recurrent infections and warts. The discovery of heterozygous mutations of CXCR4, a G-protein-coupled receptor that is required for normal hematopoiesis and lymphoid homeostasis, as a major cause of WHIM syndrome has revealed the pathogenesis of this rare disorder. The recent availability of drugs that inhibit CXCL12 binding to its receptor CXCR4 has provided an attractive pathogenesis-driven therapeutic option for this disease. © 2005 Elsevier Ltd. All rights reserved
Clinical and genetic features of Warts, Hypogammaglobulinemia, Infections and Myelokathexis (WHIM) syndrome.
No full textTaxonomy and distribution of the genus Tavanicythere Bossio, 1980 (Ostracoda, Leptocytheridae)
No full textThe genus Tavanicythere was established in 1980 by Bossio on the basis of several valves recovered in the Lower Messinian brackish deposits of the Radicondoli area (Volterra Basin, Tuscany, central Italy). Three species were included in this genus: Tavanicythere lepida Bossio (the type species), Tavanicythere etrusca Bossio and Tavanicythere pulchra Bossio. Since then, many other specimens referable to Tavanicythere have been collected from several Neogene Tuscany basins (Volterra, Valdelsa, Cinigiano-Baccinello), but no specific identifications were carried out and they were generally reported in literature as Tavanicythere sp. In this paper we have revised all the collected material. Up to 15 different new taxa have been recognised, even if only 11 are formally established herein as new species, due, in some cases, to the scarcity of valves: Tavanicythere varieornata nov. sp., Tavanicythere persculpta nov. sp., Tavanicythere posteroalata nov. sp. Tavanicythere sulcata nov. sp., Tavanicythere magna nov. sp., Tavanicythere nodosa nov. sp., Tavanicythere armata nov. sp., Tavanicythere ioachinoi nov. sp., Tavanicythere julianii nov. sp., Tavanicythere parva nov. sp. and Tavanicythere irregularis nov. sp. Only few species of Tavanicythere appear to be distributed in different basins, the majority being confined to one basin only. This could be due to particular brackish environmental conditions that triggered basin endemisms. The recovery of new Tavanicythere species lead to enlarge the stratigraphical distribution of this genus, prior limited to the Early Messinian, to the time interval Late Tortonian-Messinian. Tavanicythere seems to be widespread only in the Mediterranean basin and, in particular, in Italy (Tuscany). At present, outside of Italy it has been collected only from the Late Messinian brackish deposits of the Sorbas basin (SE Spain)
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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