1,721,015 research outputs found
Sustainable qualities: Powerful drivers of social change
Full text linkLooking attentively at the complexity of contemporary society, we can detect a variety of creative communities involved in sustainable social innovation. Behind each of these initiatives stands a group of people who have been able to imagine, develop and manage something new, beyond the standard ways of thinking and doing. They have succeeded in challenging the apparent hegemony of mainstream ideas about how problems need to be solved by providing valuable alternatives. A primary common feature of such creative communities is that most of them have sprung from collaboratively confronting the problems of everyday life. Facing up to these, they have conceived new models of thought and action where everybody wins – individuals, society and the environment. A second common feature is that they produce and are, in turn, driven by new notions of qualities: new qualities of their physical and social environments. We can refer to these as sustainable qualities: qualities that require more sustainable behaviours in order to enjoy their benefits
Self or Non‐Self? It Is also a Matter of RNA Recognition and Editing by ADAR1
No full textA‐to‐I editing is a post‐transcriptional mechanism affecting coding and non‐coding dsRNAs, catalyzed by the adenosine deaminases acting on the RNA (ADAR) family of enzymes. A‐ to‐I modifications of endogenous dsRNA (mainly derived from Alu repetitive elements) prevent their recognition by cellular dsRNA sensors, thus avoiding the induction of antiviral signaling and uncontrolled IFN‐I production. This process, mediated by ADAR1 activity, ensures the activation of an innate immune response against foreign (non‐self) but not self nucleic acids. As a consequence, ADAR1 mutations or its de‐regulated activity promote the development of autoimmune diseases and strongly impact cell growth, also leading to cancer. Moreover, the excessive inflammation promoted by Adar1 ablation also impacts T and B cell maturation, as well as the development of dendritic cell subsets, revealing a new role of ADAR1 in the homeostasis of the immune system
Case 6. Relational design practices in Belgium: Disarticulating power dynamics through fictional Offices
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
The adaptive potential of RNA editing-mediated miRNA-retargeting in cancer
No full textA-to-I RNA editing is a post-transcriptional mechanism that converts the genomically coded Adenosine (A) into Inosine (I) at the RNA level. This type of RNA editing is the most frequent in humans and is mediated by the ADAR enzymes. RNA editing can alter the genetic code of mRNAs, but also affect the functions of noncoding RNAs such as miRNAs. Recent studies have identified thousands of microRNA editing events in different cancer types. However, the important role played by miRNA-editing in cancer has been reported for just a few microRNAs. Herein, we recapitulate the current studies on cancer-related microRNA editing and discuss their importance in tumor growth and progression. This article is part of a Special Issue entitled: mRNA modifications in gene expression control edited by Dr. Soller Matthias and Dr. Fray Rupert
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