1,721,080 research outputs found
L’impatto sociale del riciclaggio di RSU: riflessioni preliminari sui risultati di una indagine in un paese dell’entroterra marchigiano
No full textNeuroprotection by Drugs, Nutraceuticals and Physical Activity
Full text linkAcute and chronic neural injuries, including stroke, brain trauma and neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), Parkinson's disease (PD), and Alzheimer's disease (AD) are associated with high morbidity and mortality rates [...]
ROTTA SUL VILLAGGIO GLOBALE, GLOBALIZZAZIONE, AMBIENTE E DIRITTI UMANI, COOPERAZIONE ALLO SVILUPPO.
No full textHeat stress as a potential risk factor for vitamin D deficiency
Full text linkRising environmental temperatures induced by climate change cause several physiological responses linked to morbidity and mortality. In this context, heat stress may also contribute to vitamin D deficiency (VDD) through its ability to activate the hypothalamus -hypophyseal axis and cortisol release. VDD may be determined by chronic cortisol exposure, becoming an indirect consequence of an imbalance in glucocorticoid metabolism induced by heat stress in living environment. Several studies suggest the ability of cortisol to increase the catabolism of vitamin D by activating the cytochrome P450 enzymes (CYP), especially CYP24A1 and CYP3A1, and to compete with vitamin D at steroid receptor level leading to potential VDD. This phenomenon could also reinforce the weak influence of non-genetic and genetic determinants of change in vitamin D levels
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
DRL Path Planning for UAV-Aided V2X Networks: Comparing Discrete to Continuous Action Spaces
No full textIt is expected that future 6G vehicular networks will rely on Unmanned Aerial Vehicles (UAVs) acting as flying Base Stations, namely Unmanned Aerial Base Stations (UABSs), in order to provide a wide range of services that current terrestrial networks cannot manage. Vehicles may exploit strong links with the UABS, enabling applications such as advanced driving and extended sensing. In this context, if vehicular users are satisfied with an appropriate Quality of Experience (QoE), they are able to upload a given amount of data for a given time window, continuously. To allow this, an efficient path planning is fundamental. This paper presents a Deep Reinforcement Learning (DRL)-based solution, where a novel reward function is proposed with the aim of offering a continuous service to vehicles. Results are presented in terms of the percentage of satisfied users and both, a continuous action space as well as a discrete action space, are considered exploiting two different DRL algorithms (i.e., Double Dueling Deep Q Network (3DQN) and Deep Deterministic Policy Gradient (DDPG)) in order to compare the two and select the best one according to the described scenario of interest
Diario e fumetti
No full textL'articolo procede ad una esemplificazione di tipologie testuali, formati e media in cui il genere diaristico si esprime nel fumetto. Per ogni tipologia viene analizzato un esemplare nei livelli e nei registri linguistici e nelle forme iconiche adottate. Ne risulta un linguaggio vicino al parlato la cui referenzialità è ricostruita dalla narrazione e dall'intermodalità. Un linguaggio di registro non sempre colloquiale ma pur sempre fortemente deittico esplorativo delle possibilità offerte dall'ambiente diamesico specifico tra cui spiccano webcomic e graphic novel
P-glycoprotein (ABCB1) and oxidative stress: Focus on Alzheimer's disease
Full text linkATP-binding cassette (ABC) transporters, in particular P-glycoprotein (encoded by ABCB1), are important and selective elements of the blood-brain barrier (BBB), and they actively contribute to brain homeostasis. Changes in ABCB1 expression and/or function at the BBB may not only alter the expression and function of other molecules at the BBB but also affect brain environment. Over the last decade, a number of reports have shown that ABCB1 actively mediates the transport of beta amyloid (Aβ) peptide. This finding has opened up an entirely new line of research in the field of Alzheimer's disease (AD). Indeed, despite intense research efforts, AD remains an unsolved pathology and effective therapies are still unavailable. Here, we review the crucial role of ABCB1 in the Aβ transport and how oxidative stress may interfere with this process. A detailed understanding of ABCB1 regulation can provide the basis for improved neuroprotection in AD and also enhanced therapeutic drug delivery to the brain
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