1,792,775 research outputs found
Tap Dak
Full text linkabstract: Tap Dak witnessed his village being burned and people being killed. He was nine years old when he was separated from his family.
“Lost Boys Found” is an ongoing, interdisciplinary project that is collecting, recording and archiving the oral histories of the Lost Boys/Girls of Sudan. The collection is a work-in-progress, seeking to record the oral history of as many Lost Boys/Girls as are willing, and will be used in a future book.Age: 22Region: Southern SudanThis picture and bio was donated to the "Lost Boys Found" ora history project from The Arizona Lost Boys Cente
Varicellovirus UL 49.5 proteins differentially affect the function of the transporter associated with antigen processing, TAP
No full textCytotoxic T-lymphocytes play an important role in the protection against viral infections, which they detect through the recognition of virus-derived peptides, presented in the context of MHC class I molecules at the surface of the infected cell. The transporter associated with antigen processing (TAP) plays an essential role in MHC class I–restricted antigen presentation, as TAP imports peptides into the ER, where peptide loading of MHC class I molecules takes place. In this study, the UL49.5 proteins of the varicelloviruses bovine herpesvirus 1 (BHV-1), pseudorabies virus (PRV), and equine herpesvirus 1 and 4 (EHV-1 and EHV-4) are characterized as members of a novel class of viral immune evasion proteins. These UL49.5 proteins interfere with MHC class I antigen presentation by blocking the supply of antigenic peptides through inhibition of TAP. BHV-1, PRV, and EHV-1 recombinant viruses lacking UL49.5 no longer interfere with peptide transport. Combined with the observation that the individually expressed UL49.5 proteins block TAP as well, these data indicate that UL49.5 is the viral factor that is both necessary and sufficient to abolish TAP function during productive infection by these viruses. The mechanisms through which the UL49.5 proteins of BHV-1, PRV, EHV-1, and EHV-4 block TAP exhibit surprising diversity. BHV-1 UL49.5 targets TAP for proteasomal degradation, whereas EHV-1 and EHV-4 UL49.5 interfere with the binding of ATP to TAP. In contrast, TAP stability and ATP recruitment are not affected by PRV UL49.5, although it has the capacity to arrest the peptide transporter in a translocation-incompetent state, a property shared with the BHV-1 and EHV-1 UL49.5. Taken together, these results classify the UL49.5 gene products of BHV-1, PRV, EHV-1, and EHV-4 as members of a novel family of viral immune evasion proteins, inhibiting TAP through a variety of mechanisms
Adaptive System Identification with Tap-Assignment in Oversampled and Critically Sampled Subbands
No full textAdaptation of the tap profile in subband adaptive system identification problems can further enhance the efficient use of computational resources if implemented on a DSP with an otherwise too tight benchmark performance. Here, we derive a generalisation of previous work to extend tap-assignment algorithms to a new class of oversampled filter banks with non-uniform bandwidths and different subsampling rations. We compare efficiency and adaptation results for this approach to the critically sampled case and a fullband identification with same complexity
Tap and Jazz Dance in Higher Education: Uncovering the Significance of Tap and Jazz Dance Training in University Dance Studies
Full text linkThe values system in the United States is based in Western intellectual tradition, which has caused an imbalance in the availability to study certain forms of dance at the collegiate level. Ballet and modern dance are accepted as individual art forms that are culturally rich. Meanwhile, tap and jazz dance are often viewed as subordinate dance forms. Even today, some people consider these forms of dance as mere entertainment and will not credit them as true art forms. Likewise, a majority of dance programs in United States’ universities do not offer courses in these forms, and even fewer require students to study them. Unfortunately, the United States has turned away from its own cultural forms of dance rather than nurturing their practice and growth.
History shows that this neglect is rooted in racism and classism, which also permeates the education system. Tap and jazz dance are sophisticated art forms that have moved audiences for over a century. Yet, there are extremely limited opportunities to study these forms in the university system. This research project was designed to demonstrate through multiple lenses the dire need for a stronger presence of tap and jazz dance in higher education. The historical suppression of these art forms is examined while considering how the dichotomy of the development of ballet and modern dance versus the development of tap and jazz dance affected the cultural response to each. A case study is presented in which classically trained ballet and modern dancers received tap dance training, and then analysis and observations were collected on the benefits of this training in all of their dancing. Lastly, four voices from the professional realm of dance speak to the importance of the availability of tap and jazz dance in the university setting
Project Tap Collection - Accession 1437 - M705 (761)
No full textThe Project Tap Collection consists of two copies of I am Not Born Yet But I Have A Looking Glass: Student Poetry Project Tap edited by Michael Waters and published by the South Carolina Arts: Commission: Columbia, SC in 1975. The publication consist of student poetry from Chester District Schools (Dora Jones-Gayle Elementary School, Southside Elementary School, and York Road Elementary School), Fort Mill District Schools (Fort Mill Senior High and Fort Mill Junior High), and Lancaster County Schools (Buford High, Erwin Elementary, Flat Creek Elementary, Indian Land Elementary, and Kershaw Middle School). Project TAP (Total Arts Program) was created to place artists in the participating public schools.https://digitalcommons.winthrop.edu/manuscriptcollection_findingaids/2397/thumbnail.jp
<i>N-TAP-ARP6</i> and <i>C-TAP-ARP6</i> transgenes rescue the <i>arp6-1</i> phenotype.
No full text(A- upper blot) T2 plants homozygous for N-TAP- or C-TAP-ARP6 transgenes express a fusion protein with the expected size of 67.5 kDa. The fusion protein is specifically detected only in transgenic plants and not in arp6-1 or WT plants using a peroxidase anti-peroxidase (PAP) soluble complex, which binds the protein A moiety of the TAP tag. (A- lower blot) The same protein extracts as in the upper blot were probed with a monoclonal ARP6 antibody. ARP6 presence is specifically detected in all transgenic plants as a 67.5 kDa fusion protein band compared to the 44 kDa ARP6 band in WT plants, and is absent in arp6-1 mutant plants. The ARP6 antibody reacts less strongly with N-TAP-ARP6, most likely because the antibody recognizes the N-terminal region, which is adjoined to the TAP tag in this fusion. (B) Transgenic plants look more similar to WT plants than arp6-1 plants, with more compacted, non-serrated rosette leaves. (C) Early flowering phenotype is rescued in transgenic plants when compared to the arp6-1. (D) The average number of rosette leaves of N-TAP-ARP6 and C-TAP-ARP6 transgenic plants at flowering is significantly higher than in arp6-1 (n = 6 for WT and arp6-1, and n = 12 for N-TAP 11–4 and C-TAP 10–2). Asterisks indicate significant differences from arp6-1 plants with parp6-1 plants are rescued in N-TAP-ARP6 and C-TAP-ARP6 transgenic plants. (F) The fertility defects of arp6-1 plants are rescued in N-TAP 11–4 and C-TAP 10–2 transgenic plants.</p
Fluoride and dental caries
Full text linkFluorine was probably discovered by the chemist Scheele in 1771, and eventually isolated in 1886 by Moissan. Its presence in bones and teeth was initially disputed but eventually confirmed in the middle of the eighteenth century. In this article the author discusses the few epidemiological studies which confirm the relationship between fluoride concentration in drinking water, mottled enamel and the incidence of dental caries and also describes the Maltese scene in regards the caries level in tap water.peer-reviewe
Direct evidence that the N-terminal extensions of the TAP complex act as autonomous interaction scaffolds for the assembly of the MHC I peptide-loading complex
No full textThe loading of antigenic peptides onto major histocompatibility complex class I (MHC I) molecules is an essential step in the adaptive immune response against virally or malignantly transformed cells. The ER-resident peptide-loading complex (PLC) consists of the transporter associated with antigen processing (TAP1 and TAP2), assembled with the auxiliary factors tapasin and MHC I. Here, we demonstrated that the N-terminal extension of each TAP subunit represents an autonomous domain, named TMD0, which is correctly targeted to and inserted into the ER membrane. In the absence of coreTAP, each TMD0 recruits tapasin in a 1:1 stoichiometry. Although the TMD0s lack known ER retention/retrieval signals, they are localized to the ER membrane even in tapasin-deficient cells. We conclude that the TMD0s of TAP form autonomous interaction hubs linking antigen translocation into the ER with peptide loading onto MHC I, hence ensuring a major function in the integrity of the antigen-processing machinery
The Tap Room Rathmullan House Menus 2017
Full text linkWhen people think of a traditional country house, they are unlikely to envisage relaxed informal dining. In 2014, we decided to break the mould and embark on a project that offered our guests an alternative, more casual dining option. The Tap Room is the culmination of this thinking, with three local businesses – Kinnegar Brewing, Sacarpello & Co and Rathmullan house, working in unison to provide a memorable dining experience. The focus here is on real stone baked pizzas courtesy of Scarpello & Co. from the outdoor wood fired pizza oven, plus a selection of Irish craft beers on tap from Kinnegar Brewery. Scarpello & Co strongly believe in using the best ingredients to complement their fresh homemade dough. The result is a pizza which would not be out of place in the finest Milanese pizzeria. Kinnegar Brewing have established themselves as one of the country’s leading micro-breweries over the past 5 years. With only a 2km journey from the brewery to our Tap Room, you won’t find a fresher pint of Kinnegar anywhere in Ireland. The relaxed atmosphere and friendly service, make this the ideal location to wind down after a walk on the beach in this idyllic location on the shores of the Swilly. Since opening in 2014, the Tap Room has proved a huge success which culminated in being named in John & Sally McKennas Guides, Top 100 restaurants in Ireland for 2015.https://arrow.tudublin.ie/menus21c/1433/thumbnail.jp
TAP-tag proteomics.
No full textA. TAP—Tandem Affinity Purification; TEV–Tobacco Etch Virus protease; Prot A–protein A; SBP–Streptavidin Binding Protein. Workflow of TAP-tag proteomics and Tandem MS followed by data elaboration (MaxQuant, Proteus) in combination with extended data mining by MIST, STRING, IPA, and g:Profiler. g:Profiler results were further refined and graphically elaborated in Cytoscape using the EnrichmentMap application. B. Volcano blot (Proteus) was created to distinguish DEK/NUP214 and empty vector interactomics—a synopsis of potential DEK/NUP214 interactors. C. MIST analysis of DEK/NUP214 interactors applying a threshold of Log2 fold change corresponding to an increase of interaction of 1.5-fold and a p<0.05.</p
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