1,722,748 research outputs found
Performance evaluation of AODV and OLSR under mobility:
No full textWireless mobile ad hoc network is a infrastructureless network where each network node not only acts as a host but also acts as a router. Since the nodes are mobile,the environment is highly dynamic. For these networks to function properly a routing protocol is required that can respond to the rapid changes in the topology. Manyrouting protocols have been developed for accomplishing this task. The objective of this thesis is to study the impact of mobility on the performance of two mobile routing protocols, AODV, which is reactive routing protocol and OLSR, which is proactive routing protocol. Since not many MANETs have been deployed, most of the studies are simulation based. But for this thesis, experiments were conducted on national Open Access Research Testbed (ORBIT) for Next Generation Wireless Networks. We developed a basic framework to analyze the performance of routing protocols. We firstly evaluated the performance in a static environment where nodes are arranged in static linear topology and concluded that OLSR outperformed AODV. To study the mobility, we used Reference Point Group Mobility model that generates real life scenarios. It isclear that there is considerable cost associated with mobility. Both the protocols show decrease in throughput, higher standard deviation, more dead links and higher overhead when compared to their respective performance in static environment. However, the relative performance of AODV and OLSR depends on the mobility scenario. AODV performed better than OLSR for discrete scenario when time snapshots were taken at a lower frequency i.e. every 30 seconds. On the other hand, OLSR performed better in pseudo-continuous scenario when time snapshots were taken at higher frequency i.e. every 5 seconds.M.S.Includes bibliographical references (p. 41-42)by Tanuja Kuma
Einfluss von ZNS-Verletzung auf die m-RNA-Expression der Protease-Aktivierenden Rezeptoren (PARs) und Indentifizierung eines Interaktionspartners für PAR-2 in Retina
Full text linkProtease-activated receptor, optic nerve crush, focal ischemia, protein-protein interaction, alpha crystallin AMagdeburg, Univ., Fak. für Naturwiss., Diss., 2004von Tanuja RohatgiText engl
Use of Disease-Modifying Therapies in Pediatric MS
No full textPediatric multiple sclerosis (PedMS) is a rare disease with a more severe prognosis compared to adult-onset MS. It remains a challenging condition to treat because of the highly inflammatory nature of the disease, the prominent cognitive issues, and the limited knowledge about the efficacy and safety of current available disease-modifying therapies. Over the past decade, there has been a dramatic increase in the number of drugs licensed for adult-onset MS and several of them, although not tested in PedMS, are currently being used off-label in this population. To date, interferon-beta and glatiramer acetate are the most commonly used first-line treatments in children, although the efficacy and safety of these drugs have only been studied in observational cohorts and in unblinded randomized controlled trials. For children with breakthrough disease, escalation to higher efficacious second-line therapies, such as natalizumab, fingolimod, dimethyl fumarate, mitoxantrone, cyclophosphamide, rituximab, and daclizumab may be considered. Large observational studies showed natalizumab is an effective treatment with safety and efficacy comparable to those in adult populations. The safety, efficacy, and tolerability of the other second-line treatments in PedMS have been reported only in small size retrospective case series. Large phase III studies are underway which will provide important information regarding the efficacy and safety of fingolimod, teriflunomide, and dimethyl fumarate in PedMS. Symptomatic treatments for fatigue, spasticity, depression, bladder and bowel dysfunction, and neuropathic pain should be considered in PedMS, especially when these symptoms impact the quality of life. Further work is needed to ensure that new trials best address treatment outcomes tailored to PedM
Book Review: Tanuja Kothiyal, Nomadic Narratives: A History of Mobility and Identity in the Great Indian Desert
No full text Tanuja Kothiyal, Nomadic Narratives: A History of Mobility and Identity in the Great Indian Desert. New Delhi: Cambridge University Press, 2016, xiii + 299 pp., ₹734, ISBN: 9781107080317 (Hardbound). </jats:p
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Complexity of MS management in the current treatment era
Full text linkProdigious progress in the treatment of multiple sclerosis (MS) has occurred over the last 20 years, with the licensing of more than 15 novel and highly effective disease-modifying therapies (DMTs) to treat the disease. In this new complex scenario, an update of the previous therapeutic guidelines published by the American Academy of Neurology (AAN) in 2002 is needed for an appropriate and effective use of the old and new agents in clinical practice
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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