2,224 research outputs found
Decrease in serum tacrolimus level and rise in serum creatinine under late addition of Cinacalcet in a renal transplant recipient with hyperparathyroidism: A case report
No full textCinacalcet is a calcimimetic drug that has been approved for treatment of secondary and tertiary hyperparathyroidism in patients with renal failure requiring renal replacement therapy. A few cases of successful treatment in renal transplant patients immunosuppressed with cyclosporine have been reported. Herein we have reported the case of a 48-year-old renal transplant recipient presenting with secondary hypercalcemic hyperparathyroidism (parathyroid hormone [PTH] 896 pg/mL; total calcium, up to 3.3 mmol/L) under immunosuppressive therapy with tacrolimus. Owing to substantial comorbidity and a high operative risk, we decided to initiate a therapeutic trial with cinacalcet. Using a daily dose of 30 mg of Cinacalcet, normal calcium levels and a mild fall in PTH levels (decline of 62 pg/mL) were achieved within the first week of treatment. At this point, we also observed a marked decrease in tacrolimus levels (from 6.3 to 2.6 mg/dL) without any change in concomitant medications. Thus, we adapted the tacrolimus dosage. Concurrent with cinacalcet therapy, there was a rise in serum creatinine levels (from 3.9 to 4.9 mg/dL before discontinuation of cinacalcet), which was not reversible after termination of 3 weeks of treatment with cinacalcet, but continued. Cinacalcet and tacrolimus are both metabolized via cytochrome P 450. The documented decrease in tacrolimus serum levels, suggested a drug- drug interaction between tacrolimus and cinacalcet. The irreversible deterioration in renal function may be attributed to nephrotoxic properties of cinacalcet, but may also indicate an acceleration of the natural course of chronic allograft nephropathy
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3370: James Mueller
No full textPhotograph of author Jim Mueller, professor in the Mayborn school of Journalism at UNT, posing with his book, "Shooting Arrows and Slinging Mud"
Development of ergosterol, microbial biomass C, N, and P after steaming as a result of sucrose addition, and Sinapis alba cultivation
No full textA pot experiment was carried out to monitor the recovery of a steaming-reduced microbial biomass (C, N, and P) and fungal ergosterol by sucrose addition. The second objective was to investigate the recovery of a steaming-reduced microbial biomass by white mustard (Sinapis alba) cultivation and its interactions with microbial residues, freshly formed from sucrose addition. Thirty days after steaming, the soil microbial biomass C and N was still significantly reduced by 80%, leading to a rather constant microbial biomass C/N ratio around 7 throughout the experiment. The steaming-induced decreases of microbial biomass P and ergosterol were only roughly 50%, leading to a decrease in the microbial biomass C/P ratio and an increase in the ergosterol-to-microbial biomass C ratio. Sucrose addition led to a 25% reduction in the ergosterol-to-microbial biomass C ratio. Mustard cultivation had significant positive effects on microbial biomass C, N, P, and ergosterol, but the effects were smaller than those of sucrose addition. Cultivating mustard had no significant effects on the C loss or on the incorporation of sucrose C into the microbial biomass. In contrast, the application of sucrose led to a significant decrease in the mustard shoot biomass and especially in the mustard root biomass.Alexander von Humboldt Foundation (AvH
Inside a sediment‐stressed Middle Devonian carpet reef: Cave exposes details of three‐dimensional facies architecture and palaeoecology
No full textABSTRACTDuring the Middle Devonian, reef growth reached an acme, and corals and stromatoporoids colonized depositional niches commonly considered unfavourable for reefal organisms. This paper documents the detailed facies architecture and palaeoecology of a stratigraphically thin (ca 12 m, ‘carpet reef’), lower Givetian reefal body exposed along the walls and ceilings of the labyrinthine passages in the Klutert Cave in western Germany. The cave exposures (ca 26 000 m2 of rock surface) and data from short cores, neighbouring caves and outcrops document the growth and demise of an autoparabiostrome. The reef forms part of a parasequence with a lower carbonate and an upper clastic unit, bounded by flooding surfaces. Despite the comparatively small study area (ca 1 km2), the exceptional exposure quality reveals facies changes over relatively short distances both vertical and lateral. The sedimentary matrix of the reefal build‐up contains between 20 to 95 wt.‐% of clay and quartz of silt to sand fraction. Based on this observation, the corals and stromatoporoids thrived in murky waters and under sediment‐stressed conditions. Stromatoporoids, for example, display irregular ragged flanks, a feature that is in agreement with a sediment‐stressed environment. No evidence of reduced growth rates, decreased calcification rates, or lower numbers of species is found. In fact, coral diversity and density are highest within one of the two biostromal units that show peak clastic matrix values, indicating a remarkable adaptation of reef builders to sediment‐stressed conditions. The initial settlement of rugose phaceloid corals took place on a mixed clastic–carbonate substrate (the basal flooding surface). Up‐section, a succession of coral–stromatoporoids is present that is here described in great detail. Reef collapse occurred when much of the accommodation space was filled, and argillaceous sediments suffocated stromatoporoids and corals in a protected, low‐energy environment.Deutsche Forschungsgemeinschaft
http://dx.doi.org/10.13039/50110000165
Data for "Mueller Matrix Extrapolations from Linear Partial Polarimetry"
No full textTo demonstrate our method for extrapolating full, depolarizing Mueller matrices from fewer than 16 measurements, we measured an ensemble of roughened plastic bricks using a Mueller imaging polarimeter and a linear Stokes camera. The Mueller matrix images from the Mueller imaging polarimeter and the images taken with four polarizer orientations from the linear Stokes camera are included.
For inquiries regarding the contents of this dataset, please contact the Corresponding Author listed in the README.txt file. Administrative inquiries (e.g., removal requests, trouble downloading, etc.) can be directed to [email protected]</p
Near-Infrared Human Eye Mueller Matrix Images
No full textNear-infrared Mueller matrix images of 20 human subjects' eyes.
Images were taken using a dual-rotating-retarder Mueller polarimeter. The human subjects were illuminated with a diffuse near-infrared LED light source (945-955 nm) where 0.0315 W/m2 was incident on the subject’s face and/or eye. Mueller matrix images were reconstructed from 25 polarimetric measurements taken over the course of approximately 15 seconds. Due to the small, random unconscious movements of the eye, image alignment code was applied in post-processing.
For inquiries regarding the contents of this dataset, please contact the Corresponding Author listed in the README.txt file. Administrative inquiries (e.g., removal requests, trouble downloading, etc.) can be directed to [email protected]</p
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