33 research outputs found
Spatiotemporal Assessment of GHG Emissions and Nutrient Sequestration Linked to Agronutrient Runoff in Global Wetlands
No full textWetlands play a key role in regulating global greenhouse gas (GHG) emissions but anthropogenic impacts on nutrients may severely alter this balance. Recent assessments indicate that almost 22% of the global wetland area may be affected by agricultural runoff. In this work, we developed and applied a dynamic mechanistic reaction network model of soil organic matter linking the carbon (C), nitrogen (N), and sulfur (S) cycles at 0.5° × 0.5° spatial resolution across the globe. The model was used to estimate GHG emissions and nutrient sequestration rates in wetlands, driven by environmental stressors including N, P, and S fertilization. Wetland annual GHG emissions are estimated to be 136 ± 12.5 Tg C-CH4, 589 ± 45.8 Tg C-CO2, and 0.3 ± 0.04 Tg N-N2O; in contrast, C, N, and S annual sequestration rates are estimated to be 576 ± 88.1 Tg C, 20 ± 4.4 Tg N, and 7.4 ± 0.8 Tg S, between 2000 and 2017. N fertilization inputs were responsible for 13% N2O emissions in wetlands in the Northern Hemisphere, while tropical wetlands were major reservoirs for C, N, and S. Temperature, net primary productivity, and methanogenic microorganisms exert the major control on GHG emissions. Wetland CH4 and CO2 emissions were found to have a hysteretic relationship with seasonal soil temperature, but not N2O. A global-scale assessment is pivotal for best nutrient management practices, reducing nutrient losses, and controlling gas emissions
Anàlisi genètica i funcional de la migranya hemiplègica i la migranya comuna
No full text[cat] Aquesta tesi es centra en la genètica de la migranya. La migranya comuna és un trastorn neurològic caracteritzat per episodis recurrents de mal de cap. Els criteris de la IHS (International Headache Society) subclasifiquen la malaltia en migranya amb aura (MA) i migranya sense aura (MO). L'aura són símptomes neurològics transitoris que poden acompanyar el mal de cap. Les aures més freqüents són les aures visuals, tot i que també existeixen les aures sensorials essent l'aura hemiplègica la seva forma severa. La nostra investigació es va dividir en dues areas d'acord amb la base genètica dels trastorns, d'una banda, s'ha estudiat la genètica complexa de la migranya comuna, d'altra banda s'ha estudiat una forma rara de la migranya que presenta una herència mendeliana anomenada migranya hemiplègica familiar (FHM).
Per entendre més la base genètica de la migranya comuna es va utilitzar un estudi d'associació tipus cas-control amb gens candidats. Amb aquesta finalitat es van seleccionar al voltant de 550 pacients amb migranya (MA i MO) i el seu corresponent grup de control. Per tal d'analitzar la seva implicació en la susceptibilitat genètica a la migranya, es van triar gens que codifiquen per als canals de la superfamília heterogeni de potencial receptor transitori (Transient Receptor Potential- TRP) que se sap que estan implicats en les vies nociceptives. Aquesta feina ha donat lloc a una publicació (Carreño et al. SNP variants within the vanilloid TRPV1 and TRPV3 receptor genes are associated with migraine in the Spanish population. Am J Med Genet B Neuropsychiatr Genet. 2012).
En el cas particular de les formes monogèniques de FHM es coneixen tres gens involucrats en la malatia (CACNA1A, ATP1A2 i SCN1A), les proteïnes codificades per aquests gens tenen un paper rellevant en la neurotransmissió del glutamat. L'anàlisi funcional de les mutacions que causen FHM han mostrat en última instància un augment de l'alliberament de la neurotransmissió. En el cas de mutacions al CACNA1A s'ha vist un efecte de guany de funció, a diferència de les mutacions al ATP1A2 que presenten un efecte de pèrdua de funció. En aquest treball s'ha fet un screening mutacional per identificar mutacions en pacients per seqüenciació directa. Quan les mutacions eren suficientment interessants s'han generat construccions en vectors d'expressió per subseqüents estudis funcionals en cèl·lules eucariotes. Aquesta feina ha donat lloc a tres publicacions. A la primera (Serra et al. A mutation in the first intracellular loop of CACNA1A prevents P/Q channel modulation by SNARE proteins and lowers exocytosis. Proc Natl Acad Sci. 2010) es va identificar un canvi que modula la funció del canal de CACNA1A. Aquest estudi ajuda a explicar la contribució genètica en la heterogeneïtat clínica d'una família i a entendre millor el mecanisme molecular dels canals de calci tipus P/Q. El segon (Carreño et al. Acute striatal necrosis in hemiplegic migraine with the novo CACNA1A mutation. Headache. 2011) és un informe d'un pacient que presenta una necrosi aguda stratial. Té una rellevància clínica a causa de l'aparició primerenca dels símptomes neurològics previs als atacs hemiplègics. El tercer i últim treball (Carreño et al. Screening of the ATP1A2 and CACNA1A genes in patients with hemiplegic migraine: clinical, genetic and functional studies. [work in progress]) recull l'screening mutacional al gens ATP1A2 i CACNA1A en 19 pacients amb FHM. Es van identificar 5 mutacions prèviament descrites i dues mutacions noves.[eng] This Thesis is focused in migraine genetics, migraine is a prevalent neurological disorder characterized by recurrent episodes of headache. This research was divided in two areas according to the genetic basis of the disorders; on the one hand we studied the common migraine with a complex genetics, on the other hand we studied the rare mendelian forms of familial hemiplegic migraine (FHM).
To understand more the genetic basis of the common migraine a case-control association study approach was used with candidate genes. For that purpose, around 550 patients with migraine and their corresponding control group were selected. In order to analyze their involvement in the genetic susceptibility to migraine, we chose genes encoding for channels of the heterogeneous superfamily of Transient Receptor Potential (TRP) which are known to be involved in the nociceptive pathway.
In the particular case of FHM, a monogenic form of the disorder, there are three genes known to be involved in the FHM (CACNA1A, ATP1A2 and SCN1A), whose encoded proteins are playing a relevant role in the neurotransmission of the glutamate. Functional analysis of the mutations causing FHM have shown ultimately an increased neurotransmission release. CACNA1A previous studies reveled a gain-of-function effect from FHM mutations, unlike mutations on ATP1A2 that present a loss-of-function effect. Our work consisted on identifying mutations in patients by direct sequencing. If the mutations were interesting enough vector constructions were generated for functional studies in eukaryotic cells. This work gave rise to three publications: First; the identification of a change that modulates the function of the CACNA1A channel. This study contributes to explain the genetic contribution in the clinical heterogeneity of one family and to know more about the molecular mechanism of the P/Q calcium channel. Second; a report of a patient that presents an acute stratial necrosis that had clinical relevance because of the early onset of the neurological symptoms previous to the hemiplegic attacks. Third; a mutational screening of ATP1A2 and CACNA1A genes in 19 patients with FHM. 5 previously described mutations and two new mutations were found. Functional studies were carried out for the newly mutations
Content analysis of men's lifestyle magazines
No full textThe aim of this study is to examine the contents of men's lifestyle magazines such as Maxim, Esquire, FHM, and one women's lifestyle magazine Glanc. The author used two analytical procedures: qualitative analysis by experts group and quantitative content analysis of sentences in the selected articles of the chosen magazines. The analysis pointed out the differences between the perception of content and the actual content. If the reader has some impression of the text, it does not mean that a more detailed analysis of sentences will reach the same conclusion. Effect of text is highly individual matter - this thesis came to the conclusion that although men's lifestyle magazines can be controversial for some people, upon closer examination the magazines cannot be clearly labeled as chauvinistic, cynical, ironic or tabloid. The author devoted to these categories in detail in the quantitative part of the analysis. Key words: Maxim, FHM, Esquire, Glanc, journal, magazine, lifestyle, content analysis, theme, interview, report, medium, tabloid, chauvinism, irony, cynicis
Content analysis of men's lifestyle magazines
No full textThe aim of this study is to examine the contents of men's lifestyle magazines such as Maxim, Esquire, FHM, and one women's lifestyle magazine Glanc. The author used two analytical procedures: qualitative analysis by experts group and quantitative content analysis of sentences in the selected articles of the chosen magazines. The analysis pointed out the differences between the perception of content and the actual content. If the reader has some impression of the text, it does not mean that a more detailed analysis of sentences will reach the same conclusion. Effect of text is highly individual matter - this thesis came to the conclusion that although men's lifestyle magazines can be controversial for some people, upon closer examination the magazines cannot be clearly labeled as chauvinistic, cynical, ironic or tabloid. The author devoted to these categories in detail in the quantitative part of the analysis. Key words: Maxim, FHM, Esquire, Glanc, journal, magazine, lifestyle, content analysis, theme, interview, report, medium, tabloid, chauvinism, irony, cynicis
The Impact of Business Unit Strategy, Structure and Technical Innovativeness on Change in Management Accounting and Control Systems at the Business Unit Level: An Empirical Analysis
No full textThis study tests the hypothesis that business unit strategy and business unit structure affect change in a business unit's Management Accounting & Control System (MACS). Business units are parts of a larger 'whole' organization, such as departments, teams, strategic groups or divisions. Change in MACS has been assessed by asking managers to estimate the number of changes that has taken place in their business unit's MACS over a two-year time period. Using data from a survey amongst 61 business unit managers in the Netherlands, the study suggests that the costing & transfer pricing and reward system are relatively 'resistant to change'. The results also indicate that the administrative capacity of a business unit is the main driver of change in MACS. Finally, business unit strategy and business unit structure affect change in specific components of MACS at the business unit level, apparently depending on whether the change in MACS facilitates or influences managerial decisions. [ABSTRACT FROM AUTHOR
Marrying Black girls by Hagen Engler
No full textThe Centre for Psychological Services and Career Development (PsyCaD) in partnership with the UJ Library cordially invite you to a discussion with the author of the book: Marrying Black Girls for Guys who aren’t Black: Hagen Engler. Former editor of FHM magazine, Hagen Engler is a columnist, blogger, wordsmith and author based in Sandton. Combining anecdotes, rhymes, essays and freestyle political discourse, the book charts his personal route through his marriage to a black woman, to an integrated society. The discussion will be led by: Portia Maruping – Counselling Psychologist, Centre for Psychological Services and Career Development (PsyCaD), U
Carbon, Nitrogen, and Sulfur Elemental Fluxes in the Soil and Exchanges with the Atmosphere in Australian Tropical, Temperate, and Arid Wetlands
No full textAustralian ecosystems, particularly wetlands, are facing new and extreme threats due to climate change, land use, and other human interventions. However, more fundamental knowledge is required to understand how nutrient turnover in wetlands is affected. In this study, we deployed a mechanistic biogeochemical model of carbon (C), nitrogen (N), and sulfur (S) cycles at 0.25∘× 0.25∘ spatial resolution across wetlands in Australia. Our modeling was used to assess nutrient inputs to soil, elemental nutrient fluxes across the soil organic and mineral pools, and greenhouse gas (GHG) emissions in different climatic areas. In the decade 2008–2017, we estimated an average annual emission of 5.12 Tg-CH4, 90.89 Tg-CO2, and 2.34 × 10−2 Tg-N2O. Temperate wetlands in Australia have three times more N2O emissions than tropical wetlands as a result of fertilization, despite similar total area extension. Tasmania wetlands have the highest areal GHG emission rates. C fluxes in soil depend strongly on hydroclimatic factors; they are mainly controlled by anaerobic respiration in temperate and tropical regions and by aerobic respiration in arid regions. In contrast, N and S fluxes are mostly governed by plant uptake regardless of the region and season. The new knowledge from this study may help design conservation and adaptation plans to climate change and better protect the Australian wetland ecosystem
Marrying Black girls by Hagen Engler
No full textThe Centre for Psychological Services and Career Development (PsyCaD) in partnership with the UJ Library cordially invite you to a discussion with the author of the book: Marrying Black Girls for Guys who aren’t Black: Hagen Engler. Former editor of FHM magazine, Hagen Engler is a columnist, blogger, wordsmith and author based in Sandton. Combining anecdotes, rhymes, essays and freestyle political discourse, the book charts his personal route through his marriage to a black woman, to an integrated society. The discussion will be led by: Portia Maruping – Counselling Psychologist, Centre for Psychological Services and Career Development (PsyCaD), U
Visual Parody in Alcohol Advertisements between 1997 and 2007
No full textŠajā bakalaura darbā tiek aplūkota tēma „Vizuālās parodijas alkohola reklāmās (1997. – 2007. g.)”. Pētījuma lauks iekļauj četrus, Latvijā iznākošus, dzīvesstila žurnālus – FHM, Klubs, Lilit un Santa. Par pētījuma objektu tiek uzlūkotas 200 alkohola reklāmas vienības, no kurām 20 reklāmas vienības autore pētījusi detalizēti.
Darbs tiek balstīts uz teorētisko bāzi, kurā tiek aplūkoti vizuālās komunikācijas teorētiskie aspekti, kā arī vizuālās komunikācijas elementi. Teorētiski tiek pamatots arī dzīvesstila, zīmju un simboli jēdzienu skaidrojums.
Darba empīriskajā daļā autore piedāvā pētījuma izklāstu, izmantojot kvantitatīvās kontentanalīzes un vizuālās semiotikas pētniecības metodes.This bachelor paper treats „Visual Parody in Alcohol Advertisements of 1997. – 2007. year. The Exploring field includes four Latvian lifestile magazines – FHM, Klubs, Lilit, Santa. As an exploration object is taken 200 alcohol advertisements, incorporated 20 advertisments that the Author has investigated in details.
The Paper is based on theoretical part that deals with visual communication aspects and elements. Lifestyle, signs and symbols are also described from theoretical aspects.
In the empiric part of the paper the author proffers investigation presentment – quantitative content analyses and visual semiotics research methods
Análisis de la administración estratégica de la Fundación Hermano Miguel para proponer la mejora del plan estratégico actual y diseñar el cuadro de mando integral como una herramienta de apoyo de su gestión
No full textEste estudio se realizó en la Fundación Hermano Miguel (FHM), ubicada en el norte de la ciudad de Quito, es una organización sin fines de lucro que brinda servicios de rehabilitación integral a personas con algún tipo de discapacidad, especialmente de escasos recursos económicos. Esta organización posee un plan estratégico definido años atrás, lo han ido actualizando, pero la FHM ha experimentado un estancamiento en su crecimiento, así como muchas otras organizaciones en el Ecuador. Según bibliografía revisada esto se atribuye en su mayoría a que las organizaciones no aplican eficientemente la administración estratégica.
El objetivo de este trabajo es el análisis de la administración estratégica de la FHM, centrándose en sus componentes principales: planificación estratégica actual, plan operativo vigente y su ejecución. Esto se hace sobre la base de las tres preguntas que sugiere el autor (Thompson et al, 2012), ¿Dónde estamos? ¿A dónde vamos?, Y ¿Cómo llegamos? El resultado de este trabajo establece una diferente planificación estratégica, que permita alcanzar la visión planteada. Para el efecto, se propone su Cuadro de Mando Integral, CMI. La propuesta del plan estratégico se realiza a partir del análisis ambiente externo aplicando el método de las siete preguntas que propone (Thompson et al, 2012).This study was carried out at Fundación Hermano Miguel FHM, located in the north of the city of Quito, is a non-profit organization that provides comprehensive rehabilitation services to people with some type of disability, especially of limited economic resources. This organization has a strategic plan defined years ago, have been updating, but the foundation has experienced a stagnation in its growth, as well as many other organizations in Ecuador. According to bibliography reviewed this is attributed for the most part to the fact that organizations do not efficiently apply strategic management. The objective of this work is the analysis of the strategic administration of the FHM, focusing on its main components: current strategic planning, current operational plan and its execution. This is done on the basis of the three questions that author (Thompson et al, 2012) suggests, where are we? Where do we go? And how do we get there? The result of this work establishes a different strategic planning, that allows to reach the vision raised. For this purpose, its Integral Scoreboard is proposed. The proposal of the strategic plan is made from the external environment analysis applying the method of the seven questions proposed by (Thompson et al, 2012).Mejía Guzmán, Kléber Hernán, directo
