3,245 research outputs found

    Letter from Cy Donner to Michi Weglyn, June 2, 1967

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    A letter from Cy Donner to Michi Weglyn encouraging her to come out to California to talk to producers about two shows called "Youthquake" and "Pretty Talk".These materials are from box 73 and 74 of the Frank Chin Papers. The Frank Chin Papers contain personal and professional correspondence between Frank Chin and Michi Weglyn relating to particular projects on which either author was working as well as files related to the Day of Remembrance Tribute to Michi Weglyn

    The effect of a shear bond in the Rankine method for the fire resistance of RC columns

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    The Rankine formula has been adopted by many natural codes for designing columns and frames at ambient temperature. The method had recently been adapted for structural fire resistance prediction by Tan and co-workers [Tang CY, Tan KH. Basis and application of a simple interaction formula for steel frames under fire conditions. J Struct Engrg ASCE 2001;127(10):1206-13; Tang CY, Tan KH, Ting SK. Basis and application of a simple interaction formula for steel columns under fire conditions. J Struct Engrg ASCE 2001;127(10): 1214-20; Tan KH, Tang CY. Interaction formula for reinforced concrete columns in fire conditions. ACI Struct J 2004;101(1):19-28; Tan KH, Tang CY. Interaction model for unprotected concrete filled steel columns under standard fire conditions. J Struct Eng 2004;130:1405-13]. The conventional Rankine method considers a linear interaction of two failure modes: plastic squashing and linear elastic buckling, ignoring the coupling interaction between the two modes. Consequently, the conventional method gives lower bounds to actual failure loads. This paper discusses the physical meanings of the Rankine approach and the effect of coupling interaction (termed "shear bond" for consistency with our earlier publications) between the collapse modes on the ultimate failure load. The purpose is to demonstrate that the Rankine method is a conservative, robust, and rational method for the structural design of columns under either ambient or elevated temperatures. The approach can be further adapted to provide more accurate failure load predictions by incorporating the shear bond effect into the Rankine formula. Material deterioration at elevated temperature and the resulting effects on the strength and stability of columns are also quantified. A computer code (SAFIR), developed at the University of Liege, was used to calibrate the modified Rankine method. © 2008 Elsevier Ltd. All rights reserved.link_to_subscribed_fulltex

    Outcome of medium-dose VP-16/CY/TBI superior to CY/TBI as a conditioning regimen for allogeneic stem cell transplantation in adult patients with acute lymphoblastic leukemia

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    The choice of conditioning regimen before allogeneic stem cell transplantation (SCT) in patients with acute lymphoblastic leukemia (ALL) is important. We retrospectively compared outcomes of medium-dose VP-16/cyclophosphamide/total body irradiation (VP/CY/TBI) regimen and CY/TBI. Five hundred and twenty-nine patients (VP/CY/TBI: n = 35, CY/TBI: n = 494) who met all of the following criteria were compared: first time for SCT, aged 15-59 years; first or second complete remission at SCT; bone marrow or peripheral blood as stem cell source; and HLA phenotypically matched donor. Median age of the patients was 34 years, and patients who received VP/CY/TBI were younger (28 years vs. 34 years, P = 0.02). Cumulative incidences of relapse and non-relapse mortality (NRM) were higher for patients who received CY/TBI (P = 0.01 for relapse, P < 0.01 for NRM). After a median follow-up period of 36.9 months, 5-year overall survival (OS) rates were 82.2% in the VP/CY/TBI group and 55.2% in the CY/TBI group. OS, and disease-free survival (DFS) in the VP/CY/TBI group were shown to be significantly better by multivariate analysis [hazard ratio: 0.21 (95% confidence interval: 0.06-0.49) for DFS, hazard ratio: 0.25 (95% confidence interval: 0.08-0.59) for OS]. VP/CY/TBI was associated with a lower relapse rate and no increase in NRM, resulting in better survival than that in CY/TBI for adult ALL patients
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