412 research outputs found
sj-docx-1-opp-10.1177_10781552221104773 - Supplemental material for Perspectives toward biosimilars among oncologists: A Malaysian survey
No full textSupplemental material, sj-docx-1-opp-10.1177_10781552221104773 for Perspectives toward biosimilars among oncologists: A Malaysian survey by Soon Cien Chong, Retha Rajah, Poh Lee Chow, Hsio Ching Tan, Chin Man Chong, Kar Yee Khor, Wan Ping Lee and Wan Ying Tan in Journal of Oncology Pharmacy Practice</p
Rethinking the Common Intention Constructive Trusts in Stack v Dowden and Jones v Kernott – should the Resulting Trusts be preferred?
No full textYee Ching Leung takes the two landmark cases, Stack v Dowden [2007] UKHL 17 and Jones v Kernott [2011] UKSC 53, as starting points to consider the new Common Intention Constructive Trust approach in dealing with the issue of how the beneficial interest of a property is to be shared between two separating cohabitants. The article analyses whether this new approach should be preferred over the traditional Resulting Trust approach. The author explains the two approaches and gives three arguments in support of the Resulting Trust approach. First, it provides a greater degree of certainty, which is crucial in property law. Secondly, the traditional approach is more coherent in principle when comparing to the Common Intention Constructive Trust approach. Thirdly, the author argues that the Resulting Trust approach would not leave the discretion of judges unconfined. Toward the end of the article, the author gives two brief replies to the critics of the Resulting Trust approach. However, the Common Intention Constructive Trust approach is now the law of England and whether the Resulting Trust approach will return remains to be seen
Optimization under uncertainty in radiation therapy
No full textThesis (Ph. D.)--Massachusetts Institute of Technology, Sloan School of Management, Operations Research Center, 2007.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Includes bibliographical references (p. 175-182).In the context of patient care for life-threatening illnesses, the presence of uncertainty may compromise the quality of a treatment. In this thesis, we investigate robust approaches to managing uncertainty in radiation therapy treatments for cancer. In the first part of the thesis, we study the effect of breathing motion uncertainty on intensity-modulated radiation therapy treatments of a lung tumor. We construct a robust framework that generalizes current mathematical programming formulations that account for motion. This framework gives insight into the trade-off between sparing the healthy tissues and ensuring that the tumor receives sufficient dose. With this trade-off in mind, we show that our robust solution outperforms a nominal (no uncertainty) solution and a margin (worst-case) solution on a clinical case. Next, we perform an in-depth study into the structure of different intensity maps that were witnessed in the first part of the thesis. We consider parameterized intensity maps and investigate their ability to deliver a sufficient dose to the tumor in the presence of motion that follows a Gaussian distribution. We characterize the structure of optimal intensity maps in terms of certain conditions on the problem parameters.(cont.) Finally, in the last part of the thesis, we study intensity-modulated proton therapy under uncertainty in the location of maximum dose deposited by the beamlets of radiation. We provide a robust formulation for the optimization of proton-based treatments and show that it outperforms traditional formulations in the face of uncertainty. In our computational experiments, we see evidence that optimal robust solutions use the physical characteristics of the proton beam to create dose distributions that are far less sensitive to the underlying uncertainty.by Timothy Ching-Yee Chan.Ph.D
The spatial and temporal distribution of heavy metals in sediments of Victoria Harbour, Hong Kong
No full textAuthor name used in this publication: Chloe Wing-yee TangAuthor name used in this publication: Carman Ching-man Ip2007-2008 > Academic research: refereed > Publication in refereed journalAccepted ManuscriptPublishedGreen (AAM
Development and validation of a health literacy scale for family caregivers of older people with chronic illness
No full textBackground: family caregivers (FCs) encounter a variety of health problems in older people with chronic illness, necessitating a certain level of health literacy to access, understand, appraise and apply health information and services. This study aimed to develop and validate a scale for measuring health literacy among FCs of older people with chronic illness.Methods: concept mapping was first employed to develop a conceptual model of health literacy of FCs. Scale domains were derived from the conceptual model, and item generation was performed using deductive and inductive methods. Quantitative methods, including merging scale dimensions and items, expert reviews, cognitive interviews, and item reduction analysis, were used to refine the scale. Confirmatory factor analysis was employed to validate the scale's structure. Concurrent validity, internal consistency, and test-retest reliability were also examined.Results: a 20-dimension conceptual model was developed, and 60 items were generated for the scale. Expert review (content validity index > 0.85) and cognitive interview with FCs confirmed the relevance and clarity of the majority of the generated scale items. Confirmatory factor analysis with 451 FCs of older people with chronic illness supported a 5-factor structure (symptom management, daily personal care and household tasks, care coordination, communication and relationship with the care recipient, and self-care of caregivers) with 42 finalized scale items, including four levels of health literacy skills (accessing, understanding, appraising and applying health information). Concurrent validity with the European Health Literacy Questionnaire (HLS-EU-Q47) was satisfactory (r = 0.67, p < 0.01). The Cronbach's α coefficient of the scale was 0.96, with subscales ranging from 0.84 to 0.91. The two-week test-retest reliability was 0.77 (p < 0.01).Conclusions: this study developed a conceptual model explaining the concept and factors of health literacy among FCs of older people with chronic illness that could provide the groundwork for future studies in developing relevant evidence-based interventions. A new Health Literacy Scale-Family Caregiver (HLS-FC) with satisfactory psychometric properties was developed in this study, which can be utilized to identify caregivers with insufficient health literacy and facilitate timely interventions by healthcare professionals.</p
Phosphoproteomics Unravel HBV Triggered Rewiring of Host Phosphosignaling Events
No full textHepatitis B virus (HBV) infection persists as a major global health problem despite the availability of HBV vaccines for disease prevention. However, vaccination rates remains low in some regions of the world, driving the need for novel strategies to minimise infections and prevent disease progression. Thus, understanding of perturbed molecular signaling events during early phases of HBV infection is required. Phosphosignaling is known to be involved in the HBV infection processes, yet systems-level changes in phosphosignaling pathways in the host during infection remain unclear. To this end, we performed phosphoproteome profiling on HBV-infected HepG2-NTCP cells. Our results showed that HBV infection drastically altered the host phosphoproteome and its associated proteins, including kinases. Computational analysis of this phosphoproteome revealed dysregulation of the pathways involved in immune responses, cell cycle processes, and RNA processing during HBV infection. Kinase Substrate Enrichment Analysis (KSEA) identified the dysregulated activities of important kinases, including those from CMGC (CDK, MAPK, GSK, and CLK), AGC (protein kinase A, G, and C), and TK (Tyrosine Kinase) families. Of note, the inhibition of CLKs significantly reduced HBV infection in HepG2-NTCP cells. In all, our study unravelled the aberrated phosphosignaling pathways and the associated kinases, presenting potential entry points for developing novel therapeutic strategies for HBV treatment
Subsidiary embeddedness and its influence on the strategic decision-making of the headquarters.
No full textThis paper responds to the need for understanding how subsidiary embeddedness, which is defined as a function of three variables – resource interdependence, technological development and communication, can affect the influence the subsidiaries have on the headquarters in the making of strategic decisions
Encapsulating bacteria in reactive magnesia cement for self-healing concrete
No full textCracks in concrete are inevitable and introduce problems that cause stress loss and affects the structural integrity of the structure. Manual repairing methods are costly and negatively impact the already burdened environment which emphasises the need for cheaper and sustainable methods. An increasingly popular alternative is the study of self-healing through microbial self-healing agents. The highly alkali concrete poses as a challenge to the survival of the bacteria when directly added, thus there is a need for encapsulation to protect it. Therefore, this paper investigates the feasibility of using Reactive Magnesia Cement (RMC), that has undergone accelerated carbonation, as the encapsulation material to protect the bacteria (Bacillus Cohnii) to achieve self-healing and concurrently, the mechanical properties of the matrix are not compromised. Crack width measurements and compressive strength tests were conducted to establish the feasibility, while SEM, XRD and calorimetry tests were conducted to shed light on the microstructure and morphology of the capsule and healing products. The gradient density characteristic of the capsule, of its outer surface being covered in hydrated magnesium carbonates (HMCs) with its core region of porous brucite identified from SEM and XRD tests, explained the reason for the compressive strength being unaffected by the capsule addition. The results from addition of the proposed MgO capsule and nutrients of yeast extract and calcium lactate into the PC matrix reported complete crack healing and an 8% increase in strength explained by the pre-reaction of bacteria on the surface of the capsule with the nutrients.Bachelor of Engineering (Civil
INTEGRATED ECOLOGICAL PLANNING IN SINGAPORE: NEOTIEWPIA ECO-VILLAGE IN BUSTLING METROPOLITAN
No full textABSTRACT :The Neotiewpia Eco-Village is located within the Lim Chu Kang district at the north of Singapore. The Eco-Village only comprised of 3.5 sq km. Meanwhile the area was
dominated by farms, chalets and Sungei Buloh Wetland Reserve. In 2006, National University of Singapore, School of Design and Environment (SDE), MSc. Environmental Management and Nature Society of Singapore initiated an ecological planning exercise within the Neotiewpia site
to reduce the environmental impact from the development while providing Eco-friendly Tourism and R&D activities that feasible in the site. We did participate in the exercise and we tried explaining the ecological process, the limitation and potential development for integrated
ecological planning framework in Developing Countries like Indonesia, Brazil, etc with high ecological-values ecosystems. The Vision of Neotiewpia was “A Model Eco-Village that Respects its Natural Heritage, Builds Strong Community Links and Promotes Economic Development on Nature’s Premises." And Neotiewpia was successfully planned and designed with integrated ecological planning approach. It embraced the land evaluation and impact assessment. Further the plan was found feasible by the Singapore Government by earmarking the Lim Chu Kang and Kranji for Agri-tainment development in 2008 (although partially
implemented). The Neotiewpia or Lim Chu Kang area was found thriving with Green-Economy and Agro-Tourism. This integrated ecological planning could be translated to other areas in Developing Countries with agriculture potential and facing development pressures such as Neotiewpia. This concept would give alternate Green-Solution to the current economic crisis
Underlying Differences in the Treatment of Left Ventricular Thrombus With Non-Vitamin K Antagonist Oral Anticoagulants
No full text10.1016/j.amjcard.2019.07.001AMERICAN JOURNAL OF CARDIOLOGY1246991-99
- …
