1,721,037 research outputs found
Presentation1_Hua-Tan-Sheng-Jing Decoction Treats Obesity With Oligoasthenozoospermia by Up-Regulating the PI3K-AKT and Down-Regulating the JNK MAPK Signaling Pathways: At the Crossroad of Obesity and Oligoasthenozoospermia.PPTX
No full textBackground: Oligoasthenozoospermia is the leading cause of male infertility, seriously affecting men’s health and increasing the societal medical burden. In recent years, obesity-related oligoasthenozoospermia has attracted increased attention from researchers to find a cure. This study aimed to evaluate the efficacy of Hua-Tan-Sheng-Jing decoction (HTSJD) in treating obesity with oligoasthenozoospermia, determine its active ingredients and identify its mechanism of action.Methods: The ingredients of HTSJD were determined by combining the ultra-performance liquid chromatography with mass spectrometry (UPLC-MS/MS) and systems pharmacology approach. The common pathogenesis of obesity and oligoasthenozoospermia and the potential mechanism of HTSJD against obesity with oligoasthenozoospermia were obtained through target fishing, network construction, and enrichment analyses. Further, molecular docking of the key ingredients with the upstream receptors of the key signaling pathways of the potential mechanism was used to predict their affinity. Finally, high-fat-induced obesity with oligoasthenozoospermia rat model was constructed to determine the effects of HTSJD on semen concentration, sperm motility, body weight, and serum lipid metabolism. The key proteins were validated by immunohistochemistry (IHC).Results: A total of 70 effective components and 847 potential targets of HTSJD (H targets) were identified, of which 743 were common targets related to obesity and oligoasthenozoospermia (O-O targets) mainly enriched in the pathways related to inflammation, oxidative stress and hormone regulation. Finally, 143 common targets (H-O-O targets) for HTSJD against obesity with oligoasthenozoospermia were obtained. Combining the hub genes and the results of Gene Ontology (GO) functional and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis of H-O-O targets, PI3K-AKT and MAPK signaling pathways were identified as the key pathways. Molecular docking results showed that Diosgenin, Kaempferol, Quercetin, Hederagenin, Isorhamnetin may act on the related pathways by docking EGFR, IGF1R and INSR. The animal-based in vivo experiments confirmed that HTSJD improves the sperm quality of high-fat diet-fed rats by reducing their body weight and blood lipid levels, influencing the PI3K-AKT and MAPK signaling pathways and altering the corresponding protein expressions.Conclusion: HTSJD treats obesity with oligoasthenozoospermia by up-regulating the PI3K-AKT signaling pathway and down-regulating the MAPK signaling pathway, which are at the crossroad of obesity and oligoasthenozoospermia.</p
DataSheet1_Hua-Tan-Sheng-Jing Decoction Treats Obesity With Oligoasthenozoospermia by Up-Regulating the PI3K-AKT and Down-Regulating the JNK MAPK Signaling Pathways: At the Crossroad of Obesity and Oligoasthenozoospermia.docx
No full textBackground: Oligoasthenozoospermia is the leading cause of male infertility, seriously affecting men’s health and increasing the societal medical burden. In recent years, obesity-related oligoasthenozoospermia has attracted increased attention from researchers to find a cure. This study aimed to evaluate the efficacy of Hua-Tan-Sheng-Jing decoction (HTSJD) in treating obesity with oligoasthenozoospermia, determine its active ingredients and identify its mechanism of action.Methods: The ingredients of HTSJD were determined by combining the ultra-performance liquid chromatography with mass spectrometry (UPLC-MS/MS) and systems pharmacology approach. The common pathogenesis of obesity and oligoasthenozoospermia and the potential mechanism of HTSJD against obesity with oligoasthenozoospermia were obtained through target fishing, network construction, and enrichment analyses. Further, molecular docking of the key ingredients with the upstream receptors of the key signaling pathways of the potential mechanism was used to predict their affinity. Finally, high-fat-induced obesity with oligoasthenozoospermia rat model was constructed to determine the effects of HTSJD on semen concentration, sperm motility, body weight, and serum lipid metabolism. The key proteins were validated by immunohistochemistry (IHC).Results: A total of 70 effective components and 847 potential targets of HTSJD (H targets) were identified, of which 743 were common targets related to obesity and oligoasthenozoospermia (O-O targets) mainly enriched in the pathways related to inflammation, oxidative stress and hormone regulation. Finally, 143 common targets (H-O-O targets) for HTSJD against obesity with oligoasthenozoospermia were obtained. Combining the hub genes and the results of Gene Ontology (GO) functional and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis of H-O-O targets, PI3K-AKT and MAPK signaling pathways were identified as the key pathways. Molecular docking results showed that Diosgenin, Kaempferol, Quercetin, Hederagenin, Isorhamnetin may act on the related pathways by docking EGFR, IGF1R and INSR. The animal-based in vivo experiments confirmed that HTSJD improves the sperm quality of high-fat diet-fed rats by reducing their body weight and blood lipid levels, influencing the PI3K-AKT and MAPK signaling pathways and altering the corresponding protein expressions.Conclusion: HTSJD treats obesity with oligoasthenozoospermia by up-regulating the PI3K-AKT signaling pathway and down-regulating the MAPK signaling pathway, which are at the crossroad of obesity and oligoasthenozoospermia.</p
Dissolution and Inheritance：A Study On Ou Tan-Sheng and His Works
No full text本文以戰後初期渡海來台的作家歐坦生及為研究對象，探討其人從福州到台灣的創作樣態。出生於福州的歐坦生，中學時期開始文學創作，在嘗試不同文體後最終走向最為擅長的小說創作。福州時期，他受到戰爭氛圍與國統區的影響，逐步確立現實主義的創作理念，以小說作品關照社會，擅長刻畫小人物與諷刺的風格，具有社會批判與人文關懷色彩，並將這種風格延續至來台後的創作。1947年歐坦生赴台後立即創作了反映戰後初期台灣社會現實的小說作品，被楊逵稱之為台灣新文學的好樣本。歐坦生的小說創作也與戰後初期台灣文壇中有關如何建設台灣新文學的討論相呼應，具體實踐了如何以現實主義創作反映台灣的「一般性」與「特殊性」。進入1950年代，台灣文壇受到國家機器的高度控制，創作自由受到限制，歐坦生改以丁樹南為筆名發表作品，意欲堅持其現實主義小說創作，但只能收起作品中的社會批判與諷刺意味，改而專注於描繪日常生活中小人物的悲歡離合。1960年代開始，歐坦生逐漸收起小說創作的道路，轉向寫作理論翻譯與文藝評論的活動，翻譯一系列針對寫作初學者的寫作理論與技巧，並最早在台灣文壇提倡「小小說」這一文體。 大抵，本文透過梳理歐坦生生命經歷與文學活動，建構其人從福州到台灣完整的創作樣貌。一方面，在縱向緯度上，考察歐坦生一生的文學活動軌跡，以期探討在時代與空間的變動中作家如何堅持並實踐自己的文學理念；在橫向緯度，則將其放置於各個時空的文學場域中，考察其如何主動或被迫地不斷調整以適應文學場域的變化。另一方面本文則是透過歐坦生其人其作，折射出戰後台灣文學史曲折多變的光影。This thesis focuses on Ou Tan-Sheng, who went across the sea to Taiwan from Fuzhou in the early stage of post-war, and his works. Ou Tan-Sheng (1923-2009) was born in Fuzhou. When he was 14 years old, Ou started writing. After trying different types of literature, Ou Tan-Sheng decided to establish novel as his main form of creative writing. In Fuzhou Period, the novelist was influenced by the social environment of KMT Ruling Area and began to establish the concept of the Realism in his works. As a result, the vivid depiction of average persons and the unique style of sarcasm were throughout this period, and all these characteristics were also the main branch of novel creation in the first few years after he settled in Taiwan. In 1947, Ou instantly finished several novels reflecting the social reality of Taiwan, and these works was called “the good samples of Taiwan Literature” by Yang Kui. In addition, through these novels creation, Ou responded the discussion about how to build the Taiwanese new literature in the literary circles of Taiwan, and did the concrete practices about how to reflect the universality and the particularity of Taiwan. In 1950''s, as the government increased the mind control of cultural community, Ou Tan-Sheng’s creation was restricted. As a kind of coping method, he used Ding Shu-Nan as his pseudonym, but he also tried to concentrate more on the depiction of joys and sorrows of ordinary people than social critique and sarcasm style. Then, Ou stopped writing novels and turned to translate the writing skills in 1960''s, and he is the first one who translated and introduced the short short story theory into Taiwan literary field. Therefore, through collecting and analyzing his experiences and works, this thesis aims to locate Ou Tan-Sheng and his works in Taiwan literary history, and bring this less-studied figure into the field of literary studies. On one hand, this thesis investigates the track of his whole life and literary activities, to find out the inheritance and changes of his works. On the other hand, this thesis also puts Ou Tan-Sheng and his works into different kinds of the cultural fields, to understand his adjustment and persistence for the change of literary field
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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