16 research outputs found
Functional cooperation between FACT and the MCM helicase complex facilitates chromatin DNA replication.
No full textValidation and optimization of the Kalman filter in MIAS
No full textThe use of a Kalman filter in MIAS is discussed along with the dynamic model in the Kalman filter. Several error sources are treated, like non-optimal tuning, MLS biases, timing of the asynchronous input signals and airborne antennae displacementElectrical Engineering, Mathematics and Computer ScienceTelecommunicatie- en Verkeersbegeleidingssysteme
A user-centred re-design of indoor comfort: For the faculty of Civil Engineering and Geosciences with an energy-conscious approach
No full textAs a building ages the building performance demands may change. The CEG building is a representative case of building that has to face modern demands. Indoor comfort is a subject which does not only depend on physical parameters, but also on the occupants perception of comfort. To capture this duality this research has performed a user research. By the use of Post Occupancy Evaluation comfort complaint information was retrieved from the occupants. The user and technical data have led to a preliminary diagnosis on the building's performance. Several interventions have been reviewed that can improve the indoor climate. With the use of a simulation tool, Design Builder, several intervention profiles have been reviewed. Based on all the results a preliminary design proposal has been developed. The conclusion of this research is that a combination of active and passive solutions is required to improve the indoor climate of the CEG building. The preliminary design proposal will lead to an improvement of comfort and a decrease in energy consumption.Building Physics and Building TechnologyStructural EngineeringCivil Engineering and Geoscience
The wall - Preparing for China's urban billion
No full textThe Chinese cities grew enormously last decades, spreading to nearly infinity. Almost a billion people will live in the cities by 2025. A sharp, radical and significant course change to a new urban model is necessary to guide China towards a balanced future. The Wall can be this guide. Chengdu forms the perfect study-case for this challenge.Materialization - TALL (Vertical Cities Asia)ArchitectureArchitectur
The use of foreign copybook patterns to determine the country of origin of the author of a questioned document
No full textItem does not contain fulltext0ntbrkt
Extensive gene content variation in the Brachypodium distachyon pan-genome correlates with population structure
Full text link13 Pags.- 6 Figs. Open Access This article is licensed under a Creative Commons
Attribution 4.0 International License, which permits use, sharing,
adaptation, distribution and reproduction in any medium or format, as long as you give
appropriate credit to the original author(s) and the source, provide a link to the Creative
Commons license, and indicate if changes were made. The images or other third party
material in this article are included in the article’s Creative Commons license, unless
indicated otherwise in a credit line to the material. If material is not included in the
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regulation or exceeds the permitted use, you will need to obtain permission directly from
the copyright holderWhile prokaryotic pan-genomes have been shown to contain many more genes than any individual organism, the prevalence and functional significance of differentially present genes in eukaryotes remains poorly understood. Whole-genome de novo assembly and annotation of 54 lines of the grass Brachypodium distachyon yield a pan-genome containing nearly twice the number of genes found in any individual genome. Genes present in all lines are enriched for essential biological functions, while genes present in only some lines are enriched for conditionally beneficial functions (e.g., defense and development), display faster evolutionary rates, lie closer to transposable elements and are less likely to be syntenic with orthologous genes in other grasses. Our data suggest that differentially present genes contribute substantially to phenotypic variation within a eukaryote species, these genes have a major influence in population genetics, and transposable elements play a key role in pan-genome evolution.The work conducted by the US DOE Joint Genome Institute is supported by the Office of
Science of the US Department of Energy under Contract no. DE-AC02-05CH11231. D.P.
W. and R.A. were funded in part by the National Science Foundation (grant no.
IOS–1258126), and the Great Lakes Bioenergy Research Center (Department of Energy
Biological and Environmental Research Office of Science grant no. DE–
FCO2–07ER64494). TEJ and DLDM were supported by NSF PGRP grant IOS-0922457.
P.C. and B.C.M. were funded by
Spanish MINECO (CGL2012-39953-C02-01 and CGL2016-79790-P). B.C.M. was partially
funded by DGA—Obra Social La Caixa (grant number GA-LC-059-2011) and
Spanish MINECO (AGL2013-48756-R, CSIC13-4E-2490). PC was partially funded by
Spanish Aragon Government-European Social Fund (Bioflora).Peer reviewe
The peculiar debris disk of HD 111520 as resolved by the Gemini Planet Imager
No full textThis is the author accepted manuscript. The final version is available from American Astronomical Society / IOP Publishing via the DOI in this record.Using the Gemini Planet Imager, we have resolved the circumstellar debris disk around HD 111520 at a projected range of ∼30-100 AU in both total and polarized H-band intensity. The disk is seen edge-on at a position angle of 165° along the spine of emission. A slight inclination and asymmetric warp are covariant and alter the interpretation of the observed disk emission. We employ three point-spread function subtraction methods to reduce the stellar glare and instrumental artifacts to confirm that there is a roughly 2:1 brightness asymmetry between the NW and SE extension. This specific feature makes HD 111520 the most extreme example of asymmetric debris disks observed in scattered light among similar highly inclined systems, such as HD 15115 and HD 106906. We further identify a tentative localized brightness enhancement and scale height enhancement associated with the disk at ∼40 AU away from the star on the SE extension. We also find that the fractional polarization rises from 10% to 40% from 0.″5 to 0.″8 from the star. The combination of large brightness asymmetry and symmetric polarization fraction leads us to believe that an azimuthal dust density variation is causing the observed asymmetry.Z.H.D. and B.C.M. acknowledge a Discovery Grant and Accelerator Supplement from the Natural Science and Engineering Research Council of Canada. Supported by NSF grants AST-0909188, AST-1313718 (J.R.G., J.J.W., P.G.K.), AST-141378 (G.D., M.F.), and AST-1411868 (K.F., J.L.P., A.R., K.W.D.). Supported by NASA grants NNX15AD95G/NEXSS, NNX14AJ80G, and NNX11AD21G (J.R.G., J.J.W., P.G.K.)
Adjunctive use of celecoxib with anti-tuberculosis drugs: evaluation in a whole-blood bactericidal activity model
No full text10.1038/s41598-018-31590-4Scientific Reports811349
Pharmacokinetic and pharmacodynamic properties of polymyxin B in Escherichia coli and Klebsiella pneumoniae murine infection models
No full textBACKGROUND: Although polymyxin B has been in use since the late 1950s, there have been limited studies done to unravel its pharmacokinetics (PK) and pharmacodynamics (PD) index. METHODS: We determined, in neutropenic infected mice, the PK, plasma protein binding and PK/PD index best correlating with efficacy for Escherichia coli and Klebsiella pneumoniae strains. RESULTS: The pharmacokinetic profile showed non-linear PK; dose was significantly correlated with absorption rate and clearance. The inhibitory sigmoid dose-effect model for the fCmax/MIC index of E. coli fitted best, but was only modestly higher than the R2 of %fT>MIC and fAUC/MIC (R2 0.91-0.93). For K. pneumoniae the fAUC/MIC index had the best fit, which was slightly higher than the R2 of %fT>MIC and fCmax/MIC (R2 0.85-0.91). Static targets of polymyxin B fAUC/MIC were 27.5-102.6 (median 63.5) and 5.9-60.5 (median 11.6) in E. coli and in K. pneumoniae isolates, respectively. A 1 log kill effect was only reached in two E. coli isolates and one K. pneumoniae. The PTA with the standard dosing was low for isolates with MIC >0.25 mg/L. CONCLUSIONS: This study confirms that fAUC/MIC can describe the exposure-response relationship for polymyxin B. The 1 log kill effect was achieved in the minority of the isolates whereas polymyxin B PK/PD targets cannot be attained for the majority of clinical isolates with the standard dosing regimen, indicating that polymyxin B may be not effective against serious infections as monotherapy. © The Author(s) 2023. Published by Oxford University Press on behalf of British Society for Antimicrobial Chemotherapy. All rights reserved. For permissions, please e-mail: [email protected]
Overview of the PAN'2016 - New Challenges for Authorship Analysis: Cross-genre Profiling, Clustering, Diarization, and Obfuscation
Full text linkThe final publication is available at Springer via http://dx.doi.org/10.1007/978-3-319-44564-9_28This paper presents an overview of the PAN/CLEF evaluation lab. During the last decade, PAN has been established as the main forum of digital text forensic research. PAN 2016 comprises three shared tasks: (i) author identification, addressing author clustering and diarization (or intrinsic plagiarism detection); (ii) author profiling, addressing age and gender prediction from a cross-genre perspective; and (iii) author obfuscation, addressing author masking and obfuscation evaluation. In total, 35 teams participated in all three shared tasks of PAN 2016 and, following the practice of previous editions, software submissions were required and evaluated within the TIRA experimentation framework.The work of the first author was partially supported by the Som EMBED TIN2015-71147-C2-1-P MINECO research project and by the Generalitat Valenciana under the grant ALMA MATER (Prometeo II/2014/030). The work of the second author was partially supported by Autoritas Consulting and by Ministerio de Economía y Competitividad de España under grant ECOPORTUNITY IPT-2012-1220-430000.Rosso, P.; Rangel-Pardo, FM.; Potthast, M.; Stamatatos, E.; Tschuggnall, M.; Stein, B. (2016). Overview of the PAN'2016 - New Challenges for Authorship Analysis: Cross-genre Profiling, Clustering, Diarization, and Obfuscation. En Experimental IR Meets Multilinguality, Multimodality, and Interaction. Springer Verlag (Germany). 332-350. https://doi.org/10.1007/978-3-319-44564-9_28S332350Almishari, M., Tsudik, G.: Exploring linkability of user reviews. In: Foresti, S., Yung, M., Martinelli, F. (eds.) ESORICS 2012. LNCS, vol. 7459, pp. 307–324. Springer, Heidelberg (2012)Álvarez-Carmona, M.A., López-Monroy, A.P., Montes-Y-Gómez, M., Villaseñor-Pineda, L., Jair-Escalante, H.: INAOE’s Participation at PAN’15: author profiling task–notebook for PAN at CLEF 2015. In: Working Notes Papers of the CLEF 2015 Evaluation Labs. CEUR-WS.org, vol. 1391 (2015)Amigó, E., Gonzalo, J., Artiles, J., Verdejo, F.: A comparison of extrinsic clustering evaluation metrics based on formal constraints. Inf. Retrieval 12(4), 461–486 (2009)Argamon, S., Juola, P.: Overview of the international authorship identification competition at PAN-2011. In: Working Notes Papers of the CLEF 2011 Evaluation Labs (2011)Argamon, S., Koppel, M., Fine, J., Shimoni, A.R.: Gender, genre, and writing style in formal written texts. TEXT 23, 321–346 (2003)Bagnall, D.: Author identification using multi-headed recurrent neural networks. In: Working Notes Papers of the CLEF 2015 Evaluation Labs. CEUR-WS.org, vol. 1391 (2015)Bensalem, I., Boukhalfa, I., Rosso, P., Abouenour, L., Darwish, K., Chikhi, S.: Overview of the AraPlagDet PAN@ FIRE2015 shared task on arabic plagiarism detection. In: Notebook Papers of FIRE 2015. CEUR-WS.org, vol. 1587 (2015)Burger, J.D., Henderson, J., Kim, G., Zarrella, G.: Discriminating gender on twitter. In: Proceedings of EMNLP 2011 (2011)Burrows, S., Potthast, M., Stein, B.: Paraphrase acquisition via crowdsourcing and machine learning. ACM TIST 4(3), 43:1–43:21 (2013)Castillo, E., Cervantes, O., Vilariño, D., Pinto, D., León, S.: Unsupervised method for the authorship identification task. In: CLEF 2014 Labs and Workshops, Notebook Papers. CEUR-WS.org, vol. 1180 (2014)Chaski, C.E.: Who’s at the keyboard: authorship attribution in digital evidence invesigations. Int. J. Digit. Evid. 4, 1–13 (2005)Clarke, C.L., Craswell, N., Soboroff, I., Voorhees, E.M.: Overview of the TREC 2009 web track. In: DTIC Document (2009)Flores, E., Rosso, P., Moreno, L., Villatoro, E.: On the detection of source code re-use. In: ACM FIRE 2014 Post Proceedings of the Forum for Information Retrieval Evaluation, pp. 21–30 (2015)Flores, E., Rosso, P., Villatoro, E., Moreno, L., Alcover, R., Chirivella, V.: PAN@FIRE: overview of CL-SOCO track on the detection of cross-language source code re-use. In: Notebook Papers of FIRE 2015. CEUR-WS.org, vol. 1587 (2015)Fréry, J., Largeron, C., Juganaru-Mathieu, M.: UJM at clef in author identification. In: CLEF 2014 Labs and Workshops, Notebook Papers. CEUR-WS.org, vol. 1180 (2014)Gollub, T., Potthast, M., Beyer, A., Busse, M., Rangel, F., Rosso, P., Stamatatos, E., Stein, B.: Recent trends in digital text forensics and its evaluation. In: Forner, P., Müller, H., Paredes, R., Rosso, P., Stein, B. (eds.) CLEF 2013. LNCS, vol. 8138, pp. 282–302. Springer, Heidelberg (2013)Gollub, T., Stein, B., Burrows, S.: Ousting Ivory tower research: towards a web framework for providing experiments as a service. In: Proceedings of SIGIR 12. ACM (2012)Hagen, M., Potthast, M., Stein, B.: Source retrieval for plagiarism detection from large web corpora: recent approaches. In: Working Notes Papers of the CLEF 2015 Evaluation Labs. CEUR-WS.org, vol. 1391 (2015)van Halteren, H.: Linguistic profiling for author recognition and verification. In: Proceedings of ACL 2004 (2004)Holmes, J., Meyerhoff, M.: The Handbook of Language and Gender. Blackwell Handbooks in Linguistics, Wiley (2003)Iqbal, F., Binsalleeh, H., Fung, B.C.M., Debbabi, M.: Mining writeprints from anonymous e-mails for forensic investigation. Digit. Investig. 7(1–2), 56–64 (2010)Jankowska, M., Keselj, V., Milios, E.: CNG text classification for authorship profiling task-notebook for PAN at CLEF 2013. In: Working Notes Papers of the CLEF 2013 Evaluation Labs. CEUR-WS.org, vol. 1179 (2013)Juola, P.: An overview of the traditional authorship attribution subtask. In: Working Notes Papers of the CLEF 2012 Evaluation Labs (2012)Juola, P.: Authorship attribution. Found. Trends Inf. Retrieval 1, 234–334 (2008)Juola, P.: How a computer program helped reveal J.K. rowling as author of a Cuckoo’s calling. In: Scientific American (2013)Juola, P., Stamatatos, E.: Overview of the author identification task at PAN-2013. In:Working Notes Papers of the CLEF 2013 Evaluation Labs. CEUR-WS.org vol. 1179 (2013)Keswani, Y., Trivedi, H., Mehta, P., Majumder, P.: Author masking through translation-notebook for PAN at CLEF 2016. In: Conference and Labs of the Evaluation Forum, CLEF (2016)Koppel, M., Argamon, S., Shimoni, A.R.: Automatically categorizing written texts by author gender. Literary Linguist. Comput. 17(4), 401–412 (2002)Koppel, M., Schler, J., Bonchek-Dokow, E.: Measuring differentiability: unmasking pseudonymous authors. J. Mach. Learn. Res. 8, 1261–1276 (2007)Koppel, M., Winter, Y.: Determining if two documents are written by the same author. J. Am. Soc. Inf. Sci. Technol. 65(1), 178–187 (2014)Layton, R., Watters, P., Dazeley, R.: Automated unsupervised authorship analysis using evidence accumulation clustering. Nat. Lang. Eng. 19(1), 95–120 (2013)López-Monroy, A.P., Montes-y Gómez, M., Jair-Escalante, H., Villasenor-Pineda, L.V.: Using intra-profile information for author profiling-notebook for PAN at CLEF 2014. In: Working Notes Papers of the CLEF 2014 Evaluation Labs. CEUR-WS.org, vol. 1180 (2014)López-Monroy, A.P., Montes-y Gómez, M., Jair-Escalante, H., Villasenor-Pineda, L., Villatoro-Tello, E.: INAOE’s participation at PAN’13: author profiling task-notebook for PAN at CLEF 2013. In: Working Notes Papers of the CLEF 2013 Evaluation Labs. CEUR-WS.org, vol. 1179 (2013)Luyckx, K., Daelemans, W.: Authorship attribution and verification with many authors and limited data. In: Proceedings of COLING (2008)Maharjan, S., Shrestha, P., Solorio, T., Hasan, R.: A straightforward author profiling approach in MapReduce. In: Bazzan, A.L.C., Pichara, K. (eds.) IBERAMIA 2014. LNCS, vol. 8864, pp. 95–107. Springer, Heidelberg (2014)Mansoorizadeh, M.: Submission to the author obfuscation task at PAN 2016. In: Conference and Labs of the Evaluation Forum, CLEF (2016)Eissen, S.M., Stein, B.: Intrinsic plagiarism detection. In: Lalmas, M., MacFarlane, A., Rüger, S.M., Tombros, A., Tsikrika, T., Yavlinsky, A. (eds.) ECIR 2006. LNCS, vol. 3936, pp. 565–569. Springer, Heidelberg (2006)Mihaylova, T., Karadjov, G., Nakov, P., Kiprov, Y., Georgiev, G., Koychev, I.: SU@PAN’2016: author obfuscation-notebook for PAN at CLEF 2016. In: Conference and Labs of the Evaluation Forum, CLEF (2016)Miro, X.A., Bozonnet, S., Evans, N., Fredouille, C., Friedland, G., Vinyals, O.: Speaker diarization: a review of recent research. Audio Speech Language Process. IEEE Trans. 20(2), 356–370 (2012)Moreau, E., Jayapal, A., Lynch, G., Vogel, C.: Author verification: basic stacked generalization applied to predictions from a set of heterogeneous learners. In: Working Notes Papers of the CLEF 2015 Evaluation Labs. CEUR-WS.org, vol. 1391 (2015)Nguyen, D., Gravel, R., Trieschnigg, D., Meder, T.: How old do you think I am? a study of language and age in twitter. In: Proceedings of ICWSM 13. AAAI (2013)Peñas, A., Rodrigo, A.: A Simple measure to assess non-response. In: Proceedings of HLT 2011 (2011)Pennebaker, J.W., Mehl, M.R., Niederhoffer, K.G.: Psychological aspects of natural language use: our words, our selves. Ann. Rev. Psychol. 54(1), 547–577 (2003)Potthast, M., Barrón-Cedeño, A., Eiselt, A., Stein, B., Rosso, P.: Overview of the 2nd international competition on plagiarism detection. In: Working Notes Papers of the CLEF 2010 Evaluation Labs (2010)Potthast, M., Barrón-Cedeño, A., Stein, B., Rosso, P.: Cross-language plagiarism detection. Lang. Resour. Eval. (LREC) 45, 45–62 (2011)Potthast, M., Eiselt, A., Barrón-Cedeño, A., Stein, B., Rosso, P.: Overview of the 3rd international competition on plagiarism detection. In: Working Notes Papers of the CLEF 2011 Evaluation Labs (2011)Potthast, M., Gollub, T., Hagen, M., Graßegger, J., Kiesel, J., Michel, M., Oberländer, A., Tippmann, M., Barrón-Cedeño, A., Gupta, P., Rosso, P., Stein, B.: Overview of the 4th international competition on plagiarism detection. In: Working Notes Papers of the CLEF 2012 Evaluation Labs (2012)Potthast, M., Gollub, T., Hagen, M., Tippmann, M., Kiesel, J., Rosso, P., Stamatatos, E., Stein, B.: Overview of the 5th international competition on plagiarism detection. In: Working Notes Papers of the CLEF 2013 Evaluation Labs. CEUR-WS.org, vol. 1179 (2013)Potthast, M., Gollub, T., Rangel, F., Rosso, P., Stamatatos, E., Stein, B.: Improving the reproducibility of PAN’s shared tasks: plagiarism detection, author identification, and author profiling. In: Kanoulas, E., Lupu, M., Clough, P., Sanderson, M., Hall, M., Hanbury, A., Toms, E. (eds.) CLEF 2014. LNCS, vol. 8685, pp. 268–299. Springer, Heidelberg (2014)Potthast, M., Hagen, M., Beyer, A., Busse, M., Tippmann, M., Rosso, P., Stein, B.: Overview of the 6th international competition on plagiarism detection. In: Working Notes Papers of the CLEF 2014 Evaluation Labs. 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