1,721,046 research outputs found
Introduction to "Core-shell nanostructures for drug delivery and theranostics: Challenges, strategies, and prospects for novel carrier systems"
No full textNo abstract availabl
Core-shell nanostructures for drug delivery and theranostics: Challenges, strategies, and prospects for novel carrier systems
No full textCore-Shell Nanostructures for Drug Delivery and Theranostics: Challenges, Strategies and Prospects for Novel Carrier Systems contains valuable chapters that deal with the fundamentals of nanotechnology for drug delivery, recent developments and research in core-shell nanoparticles for drug-delivery and theranostic applications, and the potential and applications of core-shell nanofiber. This book is a highly valuable resource for scientists interested in the design and development of innovative drug delivery systems, researchers and graduate/postdoctoral students engaged in biomaterials for drug delivery, and R&D managers in the biomaterials and pharmaceutical industry
Advances in multidrug delivery from electrospun nanomaterials
No full textMultidrug delivery systems are attracting increasing interest nowadays given their great potential as a novel therapeutic combination for different diseases, including cancer. Many different approaches have been explored to create a library of multidrug systems with controlled release kinetics, able to fulfill most medical demands. In this context electrospinning, due to its versatility, represents a valuable technique to load multiple active agents into polymeric nano-microfibers. A broad range of synthetic and natural polymers can be processed into electrospun fibers, allowing the development of drug delivery systems with a broad spectrum of different chemical and physical properties. In this chapter three main methods, (1) monolithic electrospun fibers, (2) core-sheath fibers, and (3) electrospun fibers loaded with nanocarriers, will be discussed in detail, underlining the pros and cons of each technique and discussing the most representative examples reported in literature
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Idrossiapatite intrinsecamente magnetica
No full textLa presente invenzione ha per oggetto idrossiapatite intrinsecamente magnetica ed i suoi usi nella ricostruzione ossea ed ostoecartilaginea, per il trasporto di sostanze biologiche e/o di farmaci e come agente di contrast
Novel Osteointegrative Sr-Substituted Apatitic Cements Enriched with Alginate
Full text linkThe present work describes the synthesis of novel injectable, self-setting bone cements
made of strontium-substituted hydroxyapatite (Sr-HA), obtained by single-phase calcium phosphate
precursors doped with different amounts of strontium and enriched with alginate. The addition of
alginate improved the injectability, cohesion, and compression strength of the cements, without
affecting the hardening process. A Sr-HA cement exhibiting adequate hardening times and
mechanical strength for clinical applications was further tested in vivo in a rabbit model, in
comparison with a commercial calcium phosphate cement, revealing the maintenance of biomimetic
composition and porous microstructure even after one month in vivo, as well as enhanced ability to
induce new bone formation and penetration
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