86,600 research outputs found
Topical treatment of severe xerosis: Results of an observational study
No full textDry skin refers to an itchy eczema condition commonly seen, due to the extreme dryness of the skin. This situation occours when the skin protective layer which contains water, decreases. This situation can be related to physiological and pathological conditions. Objectively, skin appears dry, finely scaly, rough to the touch, sometime fissured and sometime associated with itching and/or burning. The purpose of this work is to evaluate the clinical efficacy, in the main forms of skin xerosis, of a cosmetic product for topical use, consisting of a mixture of active ingredients (L-carnitine, biotin and vitamin B12) capable of performing moisturizing, anti-inflammatory and soothing action. 30 patients were selected, and randomly divided into 2 groups: a first group of 20 patients who applied the active ingredient and a second group of 10 patients to whom the package contained a placebo. Everyone applied the product 2 times/day on affected areas. We adopted objective and subjective evaluation criteria, such as: erythema, desquamation and lichenification in a scale from 1 to 4. Furthermore, subjective symptoms were evaluated through a visual analogue scale (VAS) from 1 to 10 regarding itch. This product was capable to reduce skin xerosis in all the indications. We can therefore conclude that the use of a topical product containing L-carnitine, biotin and vitamin B12 represents a valid therapeutic approach to xerosis, induced by skin diseases such as atopic dermatitis
CO2 fractional laser: A new treatment for aging skin
No full textThe laser systems which take advantage of the close relation between wavelength and chromophore (target) handle many skin blemishes in a safe and effective way. Thanks to the resurfacing with fractional CO2 laser, patients with different degrees of photodamage can be improved with reduced healing time. The method is effective against wrinkles, acne scars (thanks to new collagen genesis and shrinkage), and in the improvement of the texture, skin elasticity and smoothness. The method is a viable response to the growing demand for results related to reduced healing time
Flash-lamp pulsed-dye laser treatment of keloids. results of an observational study
No full textObjective: Flash lamp pulsed dye laser (FPDL) was used in a selected group of patients with hypertrophic scars
and keloids. Objective of the study was to assess the efficacy on a large number of cases. Background data:
FPDL is a nonablative technology, typically used in vascular malformation therapy because of its specificity for
hemoglobin. Methods: A total of 59 patients (33 males and 26 females, mean age 37.5 years) affected by
hypertrophic postsurgical scars and keloids, underwent from four to six treatment sessions with a flash lamp
pumped pulsed dye laser. Clinical follow-up was performed 6 months after the last treatment. Results were
judged by blind observers. Results: A total of 29 patients out of 59 (49.1%) achieved excellent clearance, 15
patients (25.4%) achieved good to moderate clearance, and 12 patients (20.4%) obtained slight improvement.
Only three subjects (5%) had little or no removal of their lesion. Treatment was well tolerated with minor and
transient side effects. Conclusions: FPDL is known as a safe and effective treatment for different dermatological lesions in which skin microvessels play a key role in pathogenesis or development. This laser was
effective when applied to hypertrophic scars and keloids. Further studies in a larger set of patients, however, are required to assess a standardized and reproducible method for treating these lesions
Deep pulse fractional CO2 laser combined with a radiofrequency system: Results of a case series
No full textObjective: The purpose of this study was evaluation of the safety and efficacy of this new combined technology that adds deep ablation to thermal stimulation. Background data: Minimally ablative or subablative lasers, such as fractional CO2 lasers, have been developed in an attempt to achieve the same clinical results observed with traditional ablative lasers, but with fewer side effects. Despite being an ablative laser, the system used in this study is able to produce a fractional supply of the beam of light. Fractional ablation of skin is performed through the development of microscopic vertical columns surrounded by spared areas of epidermis and dermis, ensuring rapid wound healing and minimum down time. Simultaneous synchronized delivery of a radiofrequency (RF) current to the deeper layers of the skin completes the therapeutic scenario, ensuring an effective skin tightening effect over the entire treated area. Methods:.Nine adult patients were treated for wrinkles and acne scars using this new laser technology. An independent observer evaluated the improvement using a five point scale. Results: All patients had good results in terms of improvement of skin texture, with mild and transitory side effects. Conclusions: This novel combined system produced improvement in wrinkles and acne scars, with progressive enhancement of skin tone and elasticity. © Mary Ann Liebert, Inc. 2014
Emerging role of anti-IL23 in the treatment of psoriasis. when humanized is very promising
No full textRisankizumab is a novel anti-interleukin 23 humanized antibody developed to treat severe psoriasis. In this paper, we analyze the key information about this new drug and the results of phase 3 clinical trials already present in literature in order measure its safety and effectiveness in every day practice. Risankizumab seems to be one of the best performing drugs in the treatment of psoriasis, with a good safety profile and a dosage regimen less frequent than all other biologic agents, although head-to-head randomized clinical trials with other anti-interleukin treatments will be necessary in order to confirm these preliminary results
Trattamento topico della xerosi cutanea severa: risultati di uno studio osservazionale. [Topical treatment of severe xerosis: Results of an observational study]
No full textDry skin refers to an itchy eczema condition commonly seen, due to the extreme dryness of
the skin. This situation occours when the skin protective layer which contains water,
decreases. This situation can be related to physiological and pathological conditions.
Objectively, skin appears dry, finely scaly, rough to the touch, sometime fissured and sometime
associated with itching and/or burning.
The purpose of this work is to evaluate the clinical efficacy, in the main forms of skin
xerosis, of a cosmetic product for topical use, consisting of a mixture of active ingredients
(L-carnitine, biotin and vitamin B12) capable of performing moisturizing, anti-inflammatory
and soothing action. 30 patients were selected, and randomly divided into 2 groups: a
first group of 20 patients who applied the active ingredient and a second group of 10
patients to whom the package contained a placebo.
Everyone applied the product 2 times/day on affected areas. We adopted objective and
subjective evaluation criteria, such as: erythema, desquamation and lichenification in a
scale from 1 to 4. Furthermore, subjective symptoms were evaluated through a visual
analogue scale (VAS) from 1 to 10 regarding itch.
This product was capable to reduce skin xerosis in all the indications. We can therefore
conclude that the use of a topical product containing L-carnitine, biotin and vitamin B12
represents a valid therapeutic approach to xerosis, induced by skin diseases such as
atopic dermatitis
Photoprotection. which filters to use
No full textThe importance of preventing acute skin damage (erythema) and chronic damage (skin cancers and photoaging) resulting from exposure to ultraviolet (UV) radiation (UVB and UVA) is well understood today (1-2). However, there is still an ongoing debate about the safety of currently available UV filters, their negative impact on serum vitamin D levels, and the possibility of protecting ourselves from the newly identified harmful effects of non-ultraviolet solar radiation. It should be emphasized that while sunscreen products are excellent means of photoprotection, it is important to adopt additional preventive measures such as wearing protective clothing (wide-brimmed hats and sunglasses) and avoiding exposure during the central hours of the day (3)
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