5 research outputs found
Response inhibition training: evaluating the combined effects of varied exemplar training and consolidation
No full textThis research proposal explores the dynamics of response inhibition training, a central executive function, reflecting the capacity to withhold or stop automatic responses. While the rehabilitation of these deficits, widespread in neurological and psychiatric populations, has posed challenges to researchers and clinicians, some developments in computerized response inhibition training have indicated some promising outcomes in both learning and generalization (e.g., Houben et al., 2011, 2012). Our current research seeks to examine the different factors influencing the efficiency of response inhibition training for learning and generalization. Specifically, the central inquiry of this study concerns the influence of time between exemplars on the advantageous impacts of variable training. This study poses the question whether training with variable stimuli preceding a 24-hour break, a period that enables consolidation of memories, (Lewis & Durrant, 2011; Squire et al., 2015), is crucial for the benefit of variable practice on generalization. From a theoretical standpoint, this research intends to investigate whether the simultaneous (as opposed to separate) consolidation of varied exemplars is critical for the extraction of shared abstract knowledge
Response inhibition training: evaluating the combined effects of varied exemplar training and consolidation
No full textThis research proposal explores the dynamics of response inhibition training, a central executive function, reflecting the capacity to withhold or stop automatic responses. While the rehabilitation of these deficits, widespread in neurological and psychiatric populations, has posed challenges to researchers and clinicians, some developments in computerized response inhibition training have indicated some promising outcomes in both learning and generalization (e.g., Houben et al., 2011, 2012). Our current research seeks to examine the different factors influencing the efficiency of response inhibition training for learning and generalization. Specifically, the central inquiry of this study concerns the influence of time between exemplars on the advantageous impacts of variable training. This study poses the question whether training with variable stimuli preceding a 24-hour break, a period that enables consolidation of memories, (Lewis & Durrant, 2011; Squire et al., 2015), is crucial for the benefit of variable practice on generalization. From a theoretical standpoint, this research intends to investigate whether the simultaneous (as opposed to separate) consolidation of varied exemplars is critical for the extraction of shared abstract knowledge
Response inhibition training: evaluating the combined effects of varied exemplar training and consolidation
No full textThis research proposal explores the dynamics of response inhibition training, a central executive function, reflecting the capacity to withhold or stop automatic responses. While the rehabilitation of these deficits, widespread in neurological and psychiatric populations, has posed challenges to researchers and clinicians, some developments in computerized response inhibition training have indicated some promising outcomes in both learning and generalization (e.g., Houben et al., 2011, 2012). Our current research seeks to examine the different factors influencing the efficiency of response inhibition training for learning and generalization. Specifically, the central inquiry of this study concerns the influence of time between exemplars on the advantageous impacts of variable training. This study poses the question whether training with variable stimuli preceding a 24-hour break, a period that enables consolidation of memories, (Lewis & Durrant, 2011; Squire et al., 2015), is crucial for the benefit of variable practice on generalization. From a theoretical standpoint, this research intends to investigate whether the simultaneous (as opposed to separate) consolidation of varied exemplars is critical for the extraction of shared abstract knowledge
Colorectal cancer incidences in Lynch syndrome: a comparison of results from the prospective lynch syndrome database and the international mismatch repair consortium
No full text\ua9 2022, The Author(s).Objective: To compare colorectal cancer (CRC) incidences in carriers of pathogenic variants of the MMR genes in the PLSD and IMRC cohorts, of which only the former included mandatory colonoscopy surveillance for all participants. Methods: CRC incidences were calculated in an intervention group comprising a cohort of confirmed carriers of pathogenic or likely pathogenic variants in mismatch repair genes (path_MMR) followed prospectively by the Prospective Lynch Syndrome Database (PLSD). All had colonoscopy surveillance, with polypectomy when polyps were identified. Comparison was made with a retrospective cohort reported by the International Mismatch Repair Consortium (IMRC). This comprised confirmed and inferred path_MMR carriers who were first- or second-degree relatives of Lynch syndrome probands. Results: In the PLSD, 8,153 subjects had follow-up colonoscopy surveillance for a total of 67,604 years and 578 carriers had CRC diagnosed. Average cumulative incidences of CRC in path_MLH1 carriers at 70 years of age were 52% in males and 41% in females; for path_MSH2 50% and 39%; for path_MSH6 13% and 17% and for path_PMS2 11% and 8%. In contrast, in the IMRC cohort, corresponding cumulative incidences were 40% and 27%; 34% and 23%; 16% and 8% and 7% and 6%. Comparing just the European carriers in the two series gave similar findings. Numbers in the PLSD series did not allow comparisons of carriers from other continents separately. Cumulative incidences at 25 years were < 1% in all retrospective groups. Conclusions: Prospectively observed CRC incidences (PLSD) in path_MLH1 and path_MSH2 carriers undergoing colonoscopy surveillance and polypectomy were higher than in the retrospective (IMRC) series, and were not reduced in path_MSH6 carriers. These findings were the opposite to those expected. CRC point incidence before 50 years of age was reduced in path_PMS2 carriers subjected to colonoscopy, but not significantly so
