102,108 research outputs found
Stem cell models in ataxia-telangiectasia
No full text: Ataxia-telangiectasia is a rare neurodegenerative disease with a complex phenotype, which has recently been associated with alterations in metabolism, inadequate responses to oxidative stress and inflammation, as well as increased cardiovascular and tumor risk. All of these appear to be attributable to genetic mutations/variants in the ataxia-telangiectasia mutated gene, which encodes the ataxia-telangiectasia mutated protein. The possibility of a better phenotypic definition provides a basis for timely, personalized therapeutic intervention to reduce or prevent worsening of clinical symptoms. Several ataxia-telangiectasia mutated knock-out murine models were created, but none efficiently developed progressive ataxia, failing to recapitulate human neurodegeneration following ataxia-telangiectasia mutated deficiency. Furthermore, considering the strong awareness of the ban on the use of animals in scientific research, a great effort has been made and is still ongoing to create human cellular models of ataxia-telangiectasia with the aim of understanding in detail the molecular mechanisms of neurodegeneration and skeletal muscle defect, of being able to identify specific therapies. This review highlights human stem cell approaches as in vitro models that have been established as attempts to study the outcomes of ataxia-telangiectasia mutated inactivation regarding neurogenic and myogenic differentiation. The first attempts at differentiation from fetal tissues, through the induced pluripotent stem cell revolution and the latest urine-derived stem cells will be reviewed
Time-series forecasting using manifold learning, radial basis function interpolation, and geometric harmonics
No full textWe address a three-tier numerical framework based on nonlinear manifold learning for the forecasting of high-dimensional time series, relaxing the "curse of dimensionality"related to the training phase of surrogate/machine learning models. At the first step, we embed the high-dimensional time series into a reduced low-dimensional space using nonlinear manifold learning (local linear embedding and parsimonious diffusion maps). Then, we construct reduced-order surrogate models on the manifold (here, for our illustrations, we used multivariate autoregressive and Gaussian process regression models) to forecast the embedded dynamics. Finally, we solve the pre-image problem, thus lifting the embedded time series back to the original high-dimensional space using radial basis function interpolation and geometric harmonics. The proposed numerical data-driven scheme can also be applied as a reduced-order model procedure for the numerical solution/propagation of the (transient) dynamics of partial differential equations (PDEs). We assess the performance of the proposed scheme via three different families of problems: (a) the forecasting of synthetic time series generated by three simplistic linear and weakly nonlinear stochastic models resembling electroencephalography signals, (b) the prediction/propagation of the solution profiles of a linear parabolic PDE and the Brusselator model (a set of two nonlinear parabolic PDEs), and (c) the forecasting of a real-world data set containing daily time series of ten key foreign exchange rates spanning the time period 3 September 2001-29 October 2020
Comparison of anti-inflammatory mechanisms between doxofylline and theophylline in human monocytes
No full textMethylxanthines are important pharmacological agents in the treatment of asthma and of chronic obstructive pulmonary diseases. The present study was designed to compare the ability of doxofylline and theophylline to modulate inflammatory pathways in human monocytes
Theologisches Wörterbuch zum Alten Testament. In Verbindung mit G.W. Anderson, H. Cazelles, D.N. Freedman, S. Talmon und G. Wallis, hrsg. von H. Ringgren und H.-J. Fabri. Band V, Lief. 1-2, 3-4, 5-6, 7-8. Stuttgart, Kohlhammer, 1984-1986
No full textBogaert Pierre-Maurice. Theologisches Wörterbuch zum Alten Testament. In Verbindung mit G.W. Anderson, H. Cazelles, D.N. Freedman, S. Talmon und G. Wallis, hrsg. von H. Ringgren und H.-J. Fabri. Band V, Lief. 1-2, 3-4, 5-6, 7-8. Stuttgart, Kohlhammer, 1984-1986. In: Revue théologique de Louvain, 19ᵉ année, fasc. 4, 1988. pp. 492-493
Theologisches Wörterbuch zum Alten Testament. In verbindung mit G.W. Anderson, H. Cazelles, D.N. Freedman, Sh. Talmon und G. Wallis hrsg. von G.J. Botterweck, H. Ringgren und H.-J. Fabry. Bd. IV, lief. 1- 2, 3-4, 5, 6-7, 8-9. 1982-1984
No full textBogaert Pierre-Maurice. Theologisches Wörterbuch zum Alten Testament. In verbindung mit G.W. Anderson, H. Cazelles, D.N. Freedman, Sh. Talmon und G. Wallis hrsg. von G.J. Botterweck, H. Ringgren und H.-J. Fabry. Bd. IV, lief. 1- 2, 3-4, 5, 6-7, 8-9. 1982-1984. In: Revue théologique de Louvain, 16ᵉ année, fasc. 1, 1985. p. 83
Theologisches Wörterbuch zum Alten Testament. In verbindung mit G.W. Anderson, H. Cazelles, D.N. Freedman, Sh. Talmon und G. Wallis hrsg. von G.J. Botterweck, H. Ringgren und H.-J. Fabry. Bd. IV, lief. 1- 2, 3-4, 5, 6-7, 8-9. 1982-1984
No full textBogaert Pierre-Maurice. Theologisches Wörterbuch zum Alten Testament. In verbindung mit G.W. Anderson, H. Cazelles, D.N. Freedman, Sh. Talmon und G. Wallis hrsg. von G.J. Botterweck, H. Ringgren und H.-J. Fabry. Bd. IV, lief. 1- 2, 3-4, 5, 6-7, 8-9. 1982-1984. In: Revue théologique de Louvain, 16ᵉ année, fasc. 1, 1985. p. 83
Bibliographie Hilarion G. Petzold 1958 – 2009 mit Anhang als Einführung
No full textDieses Archiv enthält die Gesamtbibliographie der Werke des Autors nebst einiger Texte „Über H. G. Petzold“ im Schlussteil der Bibliographie sowie einen Anhang mit einer Einführung in die Architektur des Werkes in seinem wissenslogischen Aufbau als Ausarbeitung seines „Tree of Science Modells“ (2007).This archive contains the complete bibliography of the author and some texts about H. G. Petzold, moreover an epilogue with an introduction to the architecture of the works in its epistemological structure and composition and as an elaborations of Petzold’s „Tree of Science Modell (2007).https://www.fpi-publikation.de/polyloge/01-2009-petzold-h-g-gesamtbibliographie-h-g-petzold-1958-2009-updating-november2009/peerReviewedpublishedVersio
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Phase equilibria involving microemulsions (Remarks on the Talmon-Prager model)
No full textWe discuss a statistical model for microemulsions, inspired by an idea of Talmon and Prager (but with certain modifications). The surfactant is assumed to be insoluble in both oil and water, and to be distributed in thin sheets, separating oil and water regions. The sheet has a persistence length ξ K. Consecutive pieces (of area ξ2K) have independent orientations. This gives a certain entropy S to the film. The free energy includes : a) the interfacial tension y; b) the entropy S ; c) a curvature term whose sign is defined by the Bancroft rule. Interaction effects between droplets (or other shapes) appear simply as a renormalization of γ. We show that in this model all equilibria of interest take place for very low γ ∼ kT/ξ2K, i.e. very close to a particular line (the « Schulman line ») corresponding to γ = 0 in the ternary phase diagram. The detailed structure of the tie lines depends sensitively on the structure of the curvature term. But for plausible forms of this term we are able to generate only 2-phase equilibria, and we do not reproduce 3-phase equilibria. We conclude that more complex effects (involving the vicinity of a cloud point or strong attraction between droplets) are requested to explain the observed 3-phase equilibria.Nous présentons ici un modèle statistique pour les microémulsions inspiré d'une idée de Talmon et Prager (mais comportant quelques modifications). On suppose que le surfactant est insoluble à la fois dans l'huile et dans l'eau et qu'il est distribué en minces feuillets séparant les domaines d'huile et d'eau. Le feuillet a une longueur de persistance ξK. Deux éléments successifs (d'aire ξ 2K) ont des orientations indépendantes. Ceci apporte au film une certaine entropie S. L'énergie libre inclut : a) la tension interfaciale γ ; b) l'entropie S ; c) un terme de courbure dont le signe est déterminé par la règle de Bancroft. Les effets d'interaction entre gouttelettes (ou autres formes de dispersion) apparaissent simplement comme renormalisation de γ. Nous montrons que, dans ce modèle, tous les équilibres présentant un intérêt ont lieu pour les très faibles valeurs de γ ∼ kT/ξα2 K, c'est-à-dire au voisinage immédiat d'une courbe bien définie (courbe de Schulman), correspondant à γ = 0 dans le diagramme de phase temaire. La structure détaillée des lignes d'équilibre est fortement dépendante de la forme donnée au terme de courbure. Cependant les formes plausibles simples que nous avons introduites pour ce terme ne peuvent engendrer que des équilibres à deux phases et non à trois phases. Nous en concluons que des effets plus complexes (incluant le voisinage d'un point de trouble ou des attractions fortes entre gouttelettes) sont nécessaires pour expliquer les équilibres à trois phases
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