106 research outputs found
Androgen receptor-binding sites are highly mutated in prostate cancer
No full textAndrogen receptor (AR) signalling is essential in nearly all prostate cancers. Any alterations to AR-mediated transcription can have a profound effect on carcinogenesis and tumor growth. While mutations of the AR protein have been extensively studied, little is known about those somatic mutations that occur at the non-coding regions where AR binds DNA. Using clinical whole genome sequencing, we show that AR binding sites have a dramatically increased rate of mutations that is greater than any other transcription factor and specific to only prostate cancer. Demonstrating this may be common to lineage-specific transcription factors, estrogen receptor binding sites were also found to have elevated rate of mutations in breast cancer. We provide evidence that these mutations at AR binding sites, and likely other related transcription factors, are caused by faulty repair of abasic sites. Overall, this work demonstrates that non-coding AR binding sites are frequently mutated in prostate cancer and can impact enhancer activity.We thank Dogancan Ozturan, Firat Uyulur, and Kenan Sevinc for their helpful scientific discussions. Mehmet Gonen is supported by the Turkish Academy of Sciences (GEBIP; The Young Scientist Award Program) and the Science Academy of Turkey (BAGEP; The Young Scientist Award Program). Nathan Lack is supported by the Turkish Academy of Sciences (GEBIP; The Young Scientist Award Program).Lack, NA (reprint author), Koc Univ, Sch Med, TR-34450 Istanbul, Turkey, Univ British Columbia, Vancouver Prostate Ctr, Vancouver, BC V6H 3Z6, Canada, Koc Univ, Koc Univ Res Ctr Translat Med KUTTAM, TR-34450 Istanbul, Turkey.
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Epigean amphipod fauna of Gonen Stream (western Anatolia, Turkey), with the description of Gammarus gonensis sp nov.
No full textGonen Stream, which is about 134 km in length, arises from the Ida Mountains near Balikesir and flows out near Misakca to the Sea of Marmara. In order to determine the freshwater amphipod species of Gonen Stream, 8 seasonal samplings were conducted between June 2010 and June 2012. Samplings were made at 16 stations located between the upper and lower parts of the stream. As a result of the study, 3 amphipod species were found, one of which is new to science: Gammarus gonensis sp. nov. The newly described species belongs to the Gammarus pulex- group. Gammarus gonensis resembles G. uludagi G. Karaman, 1975 by having long curled setae on the second gnathopods of the males. It differs from G. uludagi by having many long setae along the anterior margins of pereopods 5 to 7 in both sexes, and by having less setose peduncular segments of antenna 2. Some other characteristic features of the newly described species are also discussed, and detailed drawings of the extremities of holotype and allotype specimens are presented.Ege University Scientific Research FundEge University [2010/SUF/002]This study was financially supported by the Ege University Scientific Research Fund (Project No.: 2010/SUF/002). The author wishes to thank the project team for their help during field studies
Spectroscopic localization by simultaneous acquisition of the double‐spin and stimulated echoes
No full textLocalization errors in MR spectroscopic imaging due to the drift of the main magnetic field and their correction
No full textLongitudinal determination of serum placental protein 13 during development of preeclampsia
No full textObjective: To determine maternal serum placental protein 13 (PP13) in normal pregnancy and preeclampsia. Methods: A prospective, longitudinal study with 41 normal pregnant women, 18 cases with preterm delivery or cervix insufficiency and 4 with developing late-onset preeclampsia. Six hundred and sixty-six maternal blood samples were obtained every 2-4 weeks starting at 5-8 weeks gestation (10-12 samples/patient) and tested for serum PP13 by ELISA. Results: In normal pregnant women delivering at term, median maternal serum PP13 levels were growing from 166 to 202 pg/ml and 382 pg/ml in the first, second and third trimester, respectively. Preeclamptic women had significantly reduced PP13 levels in the first trimester (multiples of median of 0.14 at 7-8 weeks; p = 0.005 compared to normal). PP13 in the third trimester was significantly higher compared to normal at 35-36 weeks with PP13 multiples of median of 1.79. Conclusion: This preliminary study indicates that low levels of PP13 in early pregnancy identify at-risk pregnancies, whereas high levels precede the syndrome in late pregnancy and suggest syncytiotrophoblast necrosis. Copyright (C) 2008 S. Karger AG, Basel
The Zoom ADC: An Energy Efficient ADC for High Resolution
No full textAnalog-to-digital converters (ADCs) are an indispensable part of the digital age we are living in, as they form the interface between physical reality and virtual reality. Higher ADC energy efficiency is the dominant focus of ADC design research due to the high impact of ADC energy consumption to total energy consumption of the systems they are employed in. The energy consumption of an ADC increases with its resolution within a given signal bandwidth, which makes the efficiency of high-resolution ADCs even more important. Although the average energy efficiency of ADCs improved orders of magnitude in the last two decades, the high energy consumption of high-resolution ADCs was still restrictive for a large range of applications. This thesis investigates how the zoom ADC architecture can achieve both highresolution and high energy efficiency.Electronic Instrumentatio
Robust inter-subject audiovisual decoding in functional magnetic resonance imaging using high-dimensional regression
No full textMajor methodological advancements have been recently made in the field of neural decoding, which is concerned with the reconstruction of mental content from neuroimaging measures. However, in the absence of a large-scale examination of the validity of the decoding models across subjects and content, the extent to which these models can be generalized is not clear. This study addresses the challenge of producing generalizable decoding models, which allow the reconstruction of perceived audiovisual features from human magnetic resonance imaging (fMRI) data without prior training of the algorithm on the decoded content. We applied an adapted version of kernel ridge regression combined with temporal optimization on data acquired during film viewing (234 runs) to generate standardized brain models for sound loudness, speech presence, perceived motion, face-to-frame ratio, lightness, and color brightness. The prediction accuracies were tested on data collected from different subjects watching other movies mainly in another scanner. Substantial and significant (QFDR<0.05) correlations between the reconstructed and the original descriptors were found for the first three features (loudness, speech, and motion) in all of the 9 test movies (R¯=0.62, R¯ = 0.60, R¯ = 0.60, respectively) with high reproducibility of the predictors across subjects. The face ratio model produced significant correlations in 7 out of 8 movies (R¯=0.56). The lightness and brightness models did not show robustness (R¯=0.23, R¯ = 0). Further analysis of additional data (95 runs) indicated that loudness reconstruction veridicality can consistently reveal relevant group differences in musical experience. The findings point to the validity and generalizability of our loudness, speech, motion, and face ratio models for complex cinematic stimuli (as well as for music in the case of loudness). While future research should further validate these models using controlled stimuli and explore the feasibility of extracting more complex models via this method, the reliability of our results indicates the potential usefulness of the approach and the resulting models in basic scientific and diagnostic contexts
An Explorative Study on the Relation between Patents and Venture Capital in the Semiconductor Industry
No full textInnovation SystemsTechnology, Policy and Managemen
A Hybrid ADC for High Resolution: The Zoom ADC
No full textThis paper presents a dynamic zoom ADC for audio applications. It achieves 109-dB DR, 106-dB SNR, and 103-dB SNDR in a 20-kHz bandwidth, while dissipating 1.12 mW and occupying only 0.16 mm2 in 0.16-μm CMOS. This translates to state-of-the-art energy and area efficiency. In this paper, the system- and circuit-level design of the ADC will be presented.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Electronic Instrumentation(OLD)Applied Quantum ArchitecturesMicroelectronic
A Low Power Continuous-Time Zoom ADC for Audio Applications
No full textThis paper presents a continuous-time (CT) zoom ADC for use in audio applications. Compared to previous zoom ADCs, its input impedance is mainly resistive, making it much easier to drive while still maintaining high energy efficiency. The prototype is fabricated in a 0.16 ×m CMOS process, occupies 0.27 m m2 and achieves 108.5 dB DR, 108.1 dB SNR, 106.4 dB SNDR in a 20 kHz BW, while consuming 618 ×W. This results in a state-of-the-art Schreier FoM of 183.6 dB.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Electronic InstrumentationMicroelectronic
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