1,158 research outputs found
LOWEST ELECTRONIC STATES OF .
No full textAuthor Institution: Department of Chemistry, Louisiana State UniversityPolarized luminescence excitation spectra absorption spectra and luminescence spectra of the uranyl ion () have been studied in glass matrices and as single crystals at room temperatures at and at . The results quite definitely indicate that the lowest energy absorption band of consists of three distinct electronic transitions. Information on the species of these electronic states was also provided and will be discussed
シンカク セイブツ ニ オケル D - アミノサン タイシャ ニ カンスル コウソガクテキ ケンキュウ
No full text京都大学0048新制・課程博士博士(農学)甲第8986号農博第1168号新制||農||819(附属図書館)学位論文||H13||N3505(農学部図書室)UT51-2001-F316京都大学大学院農学研究科応用生命科学専攻(主査)教授 江﨑 信芳, 教授 清水 昌, 教授 天地 輝夫学位規則第4条第1項該当Doctor of Agricultural ScienceKyoto UniversityDA
UNDERSTANDING UO BY MODELING ELECTRONIC AND VIBRATIONAL SPECTROSCOPY
No full textAuthor Institution: The Ohio State University, Columbus, OH 43210; University of Tennessee, Knoxville, TN 37996Spin-orbit configuration interaction ({\it{SO-CI}}) continues to be a valuable electronic structure tool in understanding the electronic states of small actinide containing molecules. Recent interest has a variation of a familiar actinide molecule, UO. The additional electron would appear to be a simple alteration or perturbation to an understood system, but experimentally it presents some questions for theory to investigate. Principal questions involve characterization of the lowest electronic states in UO involves occupation of the either the 5f or the 5f non-bonding orbitals and some simple excitation generates a multitude of electronic states. Use of self-consistent field with improved virtual orbital calculations ({\it{SCF}}) will again be the foundation of the {\it{SO-CISD}} determination of the potential energy surfaces ({\it{PES}}) of the ground and low lying excited states of the UO molecule. {\it{PES}} evaluation will occur along the internal coordinates of and , and will be variationally fit to determine bound vibrational levels present within the ground and low-lying excited states. Vibrational and electronic energy levels should help clarify and describe new and interesting spectra and other properties. Gibson, J. K.; Haire, R. G.; Marcalo, J.; de Matos, A. P.; Mrozik, M. K.; Pitzer, R. M.; Bursten, B. E. {\it{Organomet.}} {\bf 2007}, {\em 26}(16), 3947--3956
Abstract 5643: Physical and functional interactions of exon-skipping variants of androgen receptor with the full-length counterpart
No full textAbstract
The androgen receptor (AR) is arguably the critical driver of not only early but also advanced prostate cancer. The recent comprehensive splicing landscapes revealed that metastatic castration resistant prostate cancer harbors multiple forms of AR variants (AR-Vs), many of which have diverse patterns of inclusion/exclusion of exons (E4-8) corresponding to the ligand-binding domain. We had used AR-negative M12 prostate cancer cell line and recently reported characteristics of AR-Vs with respect to their subcellular localization and transcriptional activation on luciferase reporter driven by probasin-based promoter (AR2PB-luc)(1). While ARv5es is predominantly nuclear and constitutively active like well-documented ARv567es, many others are castration -induced variants are inactive. As many AR-Vs and the full-length AR (AR-FL) are co-expressed in the same cell, it is important to determine how these inactive AR-Vs interact with active AR including AR-FL. To this end, we examined two inactive AR-Vs namely v7es and v56es in relation to AR-FL. ARv7es, which skips exon 7, is predominantly localized in cytoplasm. ARv7es physically interacted with AR-FL. Moreover, nuclear accumulation of ARv7es was promoted by the addition of dihydrotestosterone (DHT) only in the presence of AR-FL, suggesting that ARv7es and AR-FL heterodimerize in the nuclear compartment. However, DHT-dependent transactivation of AR-FL was not affected by the presence of ARv7es. More specifically, in M12 cells, AR2PB-luc was transactivated by AR-FL to the similar extents either in the presence or absence of ARv7es. In addition, in doxycycline (Dox)-inducible ARv7es stable LNCaP cell line (LNCaP/ARv7es), the presence of ARv7es did not affect DHT-induced expression of endogenous PSA and NKX3.1 transcripts as well as transactivation of AR2PB-luc. In the similar setting, when we examined ARv56es which also physically interacted with AR-FL, Dox-induced expression of ARv56es in LNCaP/ARv56es was sufficient to induce expression of endogenous PSA and NKX3.1 transcripts. Further, DHT-induced expression of these transcripts was enhanced by ARv56es in LNCaP/ARv56es. Accordingly, we propose that AR-Vs display differential modes of action on AR-FL as exemplified by ARv7es as the bystander and v56es as the effector. 1. Oncogene (PMID: 27694897)
Citation Format: Takuma Uo, Cynthia C. Sprenger, Shihua Sun, Robert K. Bradley, Peter S. Nelson, Stephen R. Plymate. Physical and functional interactions of exon-skipping variants of androgen receptor with the full-length counterpart [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 5643. doi:10.1158/1538-7445.AM2017-5643</jats:p
Androgen Receptor Variants and Castration-resistant Prostate Cancer: Looking Back and Looking Forward
No full text
Labor market structure and monetary policy
No full textLabor market ; Monetary policy - United States ; Wages
LASER SPECTROSCOPY OF UO: CHARACTERIZATION, LIGAND FIELD ASSIGNMENTS AND DEPERTURBATION ANALYSIS OF STATES IN THE 0-3 eV RANGE
No full textAuthor Institution: Department of Chemistry, Emory University AtlantaWavelength-resolved fluorescence excitation techniques have been used to record thirty-three electronic transitions of UO at a resolution of . Nine low-lying electronic states that correlate with and were characterized. With few exceptions, assignments were unambiguously determined from observations of the first lines in at least two rotational branches. Deperturbed constants of and {\AA} have been determined for the ground state of the configuration, and and {\AA} for states of the configuration. Fitted values for the ligand field parameters . and strongly differ from their relativistic Dirac-Fock values: , and Ligand field theory calculations have been used in an attempt to provide configurational assignments for the excited states of UO. The energies of 23 electronic configurations of UO, and 19 electronic configurations of , have been calculated. The density distribution of bound states for UO and up to their ionization limits was also calculated
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