14 research outputs found
5′-CMP and 5′-UMP alleviate dexamethasone-induced muscular atrophy in C2C12 myotubes
No full textAtrogin-1 and muscle RING finger 1 (MuRF1) are ubiquitin ligases specifically expressed during skeletal muscle atrophy and mediate muscle protein degradation. In contrast, PGC-1α (peroxisome proliferator-activated receptor γ coactivator 1α), which is a master regulator of mitochondrial biosynthesis, protects skeletal muscle from atrophy. Pyrimidine nucleoside 5′-monophosphates, such as cytidine 5′-monophosphate (5′-CMP) and uridine 5′-monophosphate (5′-UMP), induce PGC-1α expression and promote myotube formation in mouse C2C12 cells. In this study, we determined the effect of 5′-CMP and 5′-UMP on muscular atrophy in C2C12 myotube cells. 5′-UMP decreased Atrogin-1 and MuRF1 mRNA levels that were upregulated by dexamethasone treatment. 5′-CMP and 5′-UMP ameliorated dexamethasone-mediated atrophy in C2C12 myotubes. Furthermore, the combination of 5′-CMP and 5′-UMP further alleviated dexamethasone-mediated atrophy. In addition, cytidine and uridine, the precursors of 5′-CMP and 5′-UMP, markedly ameliorated dexamethasone-mediated atrophy. Considering nucleotide metabolism and absorption, the active metabolites underlying the observed effects of 5′-CMP and 5′-UMP appear to be cytidine and uridine. Our results indicate that 5′-CMP alleviates muscle atrophy by activating PGC-1α and differentiation, and 5′-UMP alleviates muscle atrophy by suppressing the activation of the myolytic system, whereas the combined use of both enhances the muscle atrophy inhibitory effect. 5′-CMP and 5′-UMP may be an effective and safe treatment for muscular atrophy
Pannus-Related Mechanical Valve Dysfunction Leading to Hemodynamic Shock
No full textMechanical prosthetic valve dysfunction caused by pannus formation is rare. Pannus restricts movement of prosthetic valve leaflets, resulting in severe aortic regurgitation. We describe the case of a 77-year-old woman who presented to the emergency room with increasing dyspnea, ischemia, and shock secondary to mechanical aortic valve dysfunction. Transesophageal echocardiography showed a blockade of the leaflets of the mechanical aortic valve, with severe aortic regurgitation. She underwent emergent cardiac surgery for aortic valve replacement. Pannus formation should be considered as a potential cause of acute severe aortic regurgitation in a patient with a small-sized mechanical aortic prosthesis in the supra-annular position. On a pathological exam, extensive pannus was found on the ventricular side of the prosthetic valve, extending from the ring into the central orifice. [Arch Clin Exp Surg 2012; 1(1.000): 50-53
The effects of health education on health science teachers’ intention to recommend adolescent HPV vaccine for female students in Japan
No full textThe Japanese government suspended proactive recommendation of human papillomavirus (HPV) vaccination due to several reports of adverse events related to it in 2013. After that, the immunization rate of HPV vaccine quickly declined in Japan. Health science teachers (HSTs) are qualified and licensed teachers in charge of health care and health education for students in Japanese schools. HSTs have not recommended HPV vaccination to female students, since active governmental recommendation for HPV vaccination was halted for 5 y. We conducted a primary survey targeting HSTs (N = 39) and university students taking the HST training course (N = 123). In each group, awareness regarding HPV vaccine and disease burden was evaluated and factors related to and barriers to HPV vaccine recommendation were identified. The primary survey found that many HSTs and university students recognized their insufficient knowledge regarding the HPV vaccine. Based on the primary survey’s results, infectious disease specialists, collaborating with Japanese HSTs, developed educational slide sets on HPV vaccine. A secondary survey was conducted before and after the lecture with HSTs (N = 162), where we evaluated their intelligibility and intention to recommend HPV vaccination for female students. In the post-lecture, secondary survey, the number of HSTs who recommended the HPV vaccine to their students had statistically increased from 76 before the lecture, to 103 (p < .05). An educational lecture using appropriate materials improved HSTs’ vaccine confidence and intention to recommend the HPV vaccine to their students, verifying the study’s hypothesis
Riflessi di storia universitaria e norme di disciplinamento del clero in area subalpina da una fonte canonistica spagnola (1435 ca.)
No full textThe treatise for confessors Speculum peccatoris, confessoris simul et praedicatoris in materia restitutionis seu satisfactionis, preserved in manuscript 37 of the Biblioteca de la Real Colegiata de San Isidoro de León, offers valuable insights into the social and religious history of the Subalpine area in the first half of the fifteenth century. The author, most likely the Spanish cleric Gómez González, gathered this information during his stay in Piedmont around 1435. This essay presents several cases of abuses committed by both laypeople and members of the clergy, as described in the Speculum. These cases include references to the University of Turin, which at the time had been temporarily relocated to Chieri (1427-1434) and to Savigliano (1434-1436). All references to the University of Turin concern issues related to the management of ecclesiastical benefices and provide information on faculty members, teaching practices in canon law at the Studium generale, and the involvement of local university doctors of canon law in judicial procedures of ecclesiastical courts
Japanese version of the Munich Parasomnia Screening: translation and linguistic validation of a screening instrument for parasomnias and nocturnal behaviors
No full textYoko Komada,1 Raoul Breugelmans,2 Stephany Fulda,3 Sae Nakano,4 Aya Watanabe,4,5 Chieri Noda,4,6 Shingo Nishida,1 Yuichi Inoue1 1Department of Somnology, 2Department of Medical Education, Tokyo Medical University, Tokyo, Japan; 3Sleep and Epilepsy Center, Neurocenter of Southern Switzerland, Civic Hospital (EOC) of Lugano, Lugano, Switzerland; 4Department of International Medical Communications, Tokyo Medical University, Tokyo, 5Language Center, University of Fukui, Fukui, Japan; 6Department of Applied Linguistics and Communication, Birkbeck, University of London, London, UK Objective: There is no broad screening instrument that can comprehensively assess parasomnias and sleep-related movement disorders listed in the International Classification of Sleep Disorders. The aim of this study was to develop the Japanese version of the Munich Parasomnia Screening (MUPS), a screening instrument for parasomnias and nocturnal behaviors, which was developed and validated at the Max Planck Institute of Psychiatry. Methods: A multi-step translation methodology consisting of forward translation, back translation, expert review, and cognitive debriefing interviews was performed between June and November 2011. Results: The English version of the MUPS was translated into Japanese, and the original author performed an expert review on the basis of a detailed report on the forward and back translation steps. The cognitive debriefing was carried out in five patients with parasomnia. The mean time to fill out the questionnaire was 8 minutes (ranging from 2 to 17 minutes). The authors reviewed and discussed the results of the cognitive debriefing interviews and modified the Japanese version. The final Japanese version was confirmed to be conceptually equivalent to the original English version. Conclusion: The Japanese version of the MUPS is an easy-to-use self-rating instrument for parasomnia and nocturnal behavior screening, consistent with the original version. The usage of this instrument would enable clinicians to quickly screen the past history and current frequency of nocturnal behaviors. Keywords: translation, linguistic validation, questionnaire, sleep-related eating disorder, sleep walkin
MED26 regulates the transcription of snRNA genes through the recruitment of little elongation complex
No full textRegulation of transcription elongation by RNA polymerase II (Pol II) is a key regulatory step in gene transcription. Recently, the little elongation complex (LEC)-which contains the transcription elongation factor ELL/EAF-was found to be required for the transcription of Pol II-dependent small nuclear RNA (snRNA) genes. Here we show that the human Mediator subunit MED26 plays a role in the recruitment of LEC to a subset of snRNA genes through direct interaction of EAF and the N-terminal domain (NTD) of MED26. Loss of MED26 in cells decreases the occupancy of LEC at a subset of snRNA genes and results in a reduction in their transcription. Our results suggest that the MED26-NTD functions as a molecular switch in the exchange of TBP-associated factor 7 (TAF7) for LEC to facilitate the transition from initiation to elongation during transcription of a subset of snRNA genes
The FOXO3/PGC-1β signaling axis is essential for cancer stem cell properties of pancreatic ductal adenocarcinoma
No full textA phase 2a, randomized, double-blind, placebo-controlled trial of the efficacy and safety of the oral gonadotropin-releasing hormone antagonist, ASP1707, in postmenopausal female patients with rheumatoid arthritis taking methotrexate
No full textObjectives: Many patients with rheumatoid arthritis (RA) are not able to achieve long-term disease remission. This phase 2a study (NCT02884635) evaluated the efficacy, safety, pharmacokinetics, and pharmacodynamics of the novel, oral, gonadotropin-releasing hormone antagonist, ASP1707, in combination with methotrexate (MTX) for treatment of RA. Methods: Postmenopausal women with RA who had been receiving MTX for ≥90 days were randomized to ASP1707 30 mg twice daily or placebo for 12 weeks. The primary endpoint was the American College of Rheumatology 20% improvement criteria (ACR20) response rate at week 12. Secondary endpoints included: ACR20, ACR50, and ACR70 response rates; disease activity score (DAS)28-CRP; DAS28-ESR; Tender or Swollen Joint Counts; and remission rates. Results: Of 105 patients screened, 72 were randomized to ASP1707 30 mg twice daily (n = 37) or placebo (n = 35). ASP1707 did not improve ACR20, ACR50, or ACR70 response rates at any time point and did not improve any secondary efficacy endpoint. Plasma luteinizing hormone (LH) concentration decreased >90% in >90% of patients receiving ASP1707, with a rapid decrease to Conclusion: In the current study, ASP1707 did not demonstrate a clinical benefit.</p
PDE3 inhibitor and EGCG combination treatment suppress cancer stem cell properties in pancreatic ductal adenocarcinoma
No full textAbstractRecurrence following chemotherapy is observed in the majority of patients with pancreatic ductal adenocarcinoma (PDAC). Recent studies suggest that cancer stem cells (CSCs) may be involved in PDAC recurrence and metastasis. However, an efficient approach to targeting pancreatic CSCs remains to be established. Here we show that in cancer cells overexpressing the 67-kDa laminin receptor (67LR)-dependent cyclic GMP (cGMP) inducer, epigallocatechin-3-O-gallate (EGCG) and a phosphodiesterase 3 (PDE3) inhibitor in combination significantly suppressed the Forkhead box O3 and CD44 axis, which is indispensable for the CSC properties of PDAC. We confirmed that the EGCG and PDE3 inhibitor in combination strongly suppressed tumour formation and liver metastasis in vivo. We also found that a synthesized EGCG analog capable of inducing strong cGMP production drastically suppressed the CSC properties of PDAC and extended the survival period in vivo. In conclusion, the combination treatment of EGCG and a PDE3 inhibitor as a strong cGMP inducer could be a potential treatment candidate for the eradication of CSCs of PDAC.</jats:p
Awards, Announcements, and News
No full textAmy’s Marathon of Reading continues westward. Her Marathon of Hope project was mentioned in this column before but as it continues to gather momentum and as it relevant to the topic of this special issue, I thought it pertinent to mention it again. From her website: “ Inspired by Terry Fox’s and Rick Hansen’s Canadian journeys, Amy Mathers decided to honour her passion for reading and Canadian teen literature while working around her physical limitations through a Marathon of Books. Realising that Terry Fox could run a kilometre in six minutes during his Marathon of Hope, she figured out that she could read ten pages in the same amount of time. Thus, on her journey, ten pages will represent one kilometre travelled across Canada. Amy will be reading teen fiction books from every province and territory, exploring Canada and promoting Canadian teen authors and books by finishing a book a day for each day of 2014. She will write a review for each book she reads, and invites people to share their thoughts on the books she reads too.” For more information and to see how far Amy’s marathon has taken her so far, go to http://amysmarathonofbooks.ca/Upcoming events and exhibitsKAMLOOPS WRITERS FESTIVAL, Nov. 7-9, 2014, Old Courthouse Cultural Centre. Guest authors include children’s author Lois Peterson.WORKSHOP: Reading Challenges and Options for Young People with Disabilities. Friday, November 14, 2014; 11:30 am to 1:00 pm. REGISTRATION and more information: https://www.microspec.com/tix123/eTic.cfm?code=BOOKFAIR14 International and Canadian experts will discuss reading challenges and options for children and teens with disabilities, with examples from the IBBY Collection of Books for Young People with Disabilities. This outstanding international collection, formerly in Norway and now housed at North York Central Library, encompasses 3,000 books in traditional formats and accessible formats including sign language, tactile, Braille, and Picture Communication Symbols.There are two major opportunities to hear award winning author Kit Pearson in Toronto and Vancouver in the upcoming months. Kit will be presenting “The Sanctuary of Story” for the 8th Annual Sybille Pantazzi Memorial Lecture on Thursday November 13, 8 p.m., in the Community room, Lillian H. Smith branch of the Toronto Public Library.Kit Pearson will also be the guest speaker at A Celebration of Award Winning BC Authors and Illustrators of 2014 at A Wine and Cheese event from 7 – 9 p.m. at January 21, 2015. (Event venue still to be confirmed. Please check www.vclr.ca for updates.) The event celebrates many other BC winners and finalists of the Governor General’s Literary Awards, the BC Book Prizes, the VCLR Information Book Award, and several other important awards.For those of you in the Toronto area be sure to check out the exhibit Lest We Forget: War in Books for Young Readers, September 15 – December 6, 2014, at the Osborne Collection. In commemoration of the 100th anniversary of the beginning of the First World War.Do not forget to Celebrate Freedom to Read Week, February 22-28, 2015, the annual event that encourages Canadians to think about and reaffirm their commitment to intellectual freedom, which is guaranteed them under the Charter of Rights and Freedoms.Serendipity 2015 promises to be a tantalizing affair. An Edgy, Eerie, Exceptional Serendipity 2015 (Saturday March 7, 2015) with Holly Black, Andrew Smith, Mariko Tamaki, Molly Idle, and Kelli Chipponeri will have captivating discussions ranging from haunted dolls and worlds of nightmare, to the raw emotion and exceptional beauty of growing up. The event, a members-only event, includes breakfast, lunch, and snacks. [This may be a very good incentive to become a member!] More information at http://vclr.ca/serendipity-2015/Call for papers and presentationsYALSA is currently seeking program proposals and paper presentations for its 2015 Young Adult Services Symposium, Bringing it All Together: Connecting Libraries, Teens & Communities, to be held Nov. 6-8, 2015, in Portland, Ore. The theme addresses the key role of connection that librarians have for the teens in their community. YALSA invites interested parties to propose 90-minute programs centering on the theme, as well as paper presentations offering new, unpublished research relating to the theme. Applications for all proposals can be found http://www.ala.org/yalsa/yasymposium . Proposals for programs and paper presentations must be completed online by Dec. 1, 2014. Applicants will be notified of their proposals’ status by Feb. 1, 2015.Book Award newsThe 2014 Information Book Award Finalists. The winner and honor title, voted by members of the Children’s Literature Roundtables, will be announced November 17, 2014 in Vancouver.Before the World Was Ready: Stories of Daring Genius in Science by Claire Eamer. Annick Press. Follow Your Money by Kevin Sylvester and Michael Hlinka. Annick Press.Looks Like Daylight: Voices of Indigenous Kids by Deborah Ellis. Groundwood Books. Pay It Forward Kids: Small Acts, Big Change by Nancy Runstedler. Fitzhenry & Whiteside.Pedal It! How Bicycles are Changing the World by Michelle Mulder. Orca Book Publishers.The list of nominees for the 2015 Astrid Lindgren Memorial Award (ALMA) includes 50 first-time nominees among a total of 197 candidates from 61 countries. Canadian nominees include The Canadian Children’s Book Centre (Organisation, nominated by IBBY Canada) and authors Sarah Ellis and Marie-Francine Hébert. Full list available at http://www.alma.se/en/Nominations/Candidates/2015/The winners of the 2014 Governor General’s Literary Award will be announced November 18, 2014. The nominated titles for children’s literature (English text) are:Jonathan Auxier, (Pittsburgh, Pa.) – The Night Gardener (Penguin Canada)Lesley Choyce, (East Laurencetown, N.S.) – Jeremy Stone (Red Deer Press)Rachel and Sean Qitsualik-Tinsley – Skraelings (Inhabit Media Inc.)Raziel Reid, (Vancouver) – When Everything Feels like the Movies (Arsenal Pulp Press)Mariko Tamaki, (Oakland, Calif.) – This One Summer (Groundwood Books/House of Anansi Press)Nominations for illustration in (English) children’s literature are:Marie-Louise Gay, (Montreal) – Any Questions?, text by Marie-Louise Gay (Groundwood Books/House of Anansi Press)Qin Leng, (Toronto) – Hana Hashimoto, Sixth Violin, text by Chieri Uegaki (Kids Can Press)Renata Liwska, (Calgary) – Once Upon a Memory, text by Nina Laden (Little, Brown and Company)Julie Morstad, (Vancouver) – Julia, Child, text by Kyo Maclear (Tundra Books)Jillian Tamaki, (Brooklyn, N.Y.) – This One Summer, text by Mariko Tamaki (Groundwood Books/House of Anansi Press)Nominations for (French) children’s literature (text) are:Linda Amyot, (St-Charles-Borromée, Que.) – Le jardin d\u27Amsterdam (Leméac Éditeur)India Desjardins, (Montreal) – Le Noël de Marguerite (Les Éditions de la Pastèque)Patrick Isabelle, (Montreal) – Eux (Leméac Éditeur)Jean-François Sénéchal, (Saint-Lambert, Que.) – Feu (Leméac Éditeur)Mélanie Tellier, (Montreal) – Fiona (Marchand de feuilles)Nominations for (French) children’s literature (illustration):Pascal Blanchet, (Trois-Rivières, Que.) – Le Noël de Marguerite, text by India Desjardins (Les Éditions de la Pastèque)Marianne Dubuc, (Montreal) – Le lion et l\u27oiseau, text by Marianne Dubuc (Les Éditions de la Pastèque)Manon Gauthier, (Montreal) – Grand-mère, elle et moi…, text by Yves Nadon (Éditions Les 400 coups)Isabelle Malenfant, (Montreal) – Pablo trouve un trésor, text by Andrée Poulin (Éditions Les 400 coups)Pierre Pratt, (Montreal) – Gustave, text by Rémy Simard (Les Éditions de la Pastèque)Online resources:Welcome to the Teachers\u27 Book Bank! This database of Canadian historical fiction and non-fiction books is brought to you by the Canadian Children\u27s Book Centre with Historica Canada, and funded by the Government of Canada. These titles may be used by teachers to introduce topics and themes in Canadian history and by students carrying out research projects. Many of the books also offer opportunities for cross-curricular connections in language arts, geography, the arts, science and other subjects. In most cases, publishers have indicated specific grade levels and age ranges to guide selection. For lesson plans to go with these books, visit Historica Canada\u27s Canadian Encyclopedia. http://bookbank.bookcentre.ca/index.php?r=site/CCBCChairing Stories on Facebook Created in response to requests from former students of Gail de Vos’s online courses on Canadian Children’s Literature and Graphic Novels and comic books, this page celebrates books, their creators, and their audiences. Postings for current students too! Check it out at https://www.facebook.com/ChairingStoriesPresented by Gail de VosGail de Vos, an adjunct instructor, teaches courses on Canadian children\u27s literature, Young Adult Literature and Comic Books and Graphic Novels at the School of Library and Information Studies for the University of Alberta and is the author of nine books on storytelling and folklore. She is a professional storyteller and has taught the storytelling course at SLIS for over two decade
