842 research outputs found
Pharmacological characterization of [I-125]CHIBA-1006 binding, a new radioligand for alpha 7 nicotinic acetylcholine receptors, to rat brain membranes
No full textThe alpha 7 nicotinic acetylcholine receptors (nAChRs) play an important role in the pathophysiology of neuropsychiatric diseases such as schizophrenia and Alzheimer's disease. However, there are currently no suitable small molecule radioligands for imaging alpha 7 nAChRs in the brain. In this study, we synthesized the novel radioligand [I-125]4-iodophenyl 1,4-diazaicyclo[3.2.2]nonane-4-carboxylate ([I-125]CHIBA-1006), a iodine-derivative of the selective alpha 7 nAChR agonist SSR180711, and studied the characterization of [I-125]CHIBA-1006 binding to rat brain membranes. The assays of [I-125]CHIBA-1006 binding to rat brain membranes were performed at 4 degrees C. The presence of a single saturable high-affinity binding component for [I-125] CHIBA-1006 in the rat brain was shown. Scatchard analysis revealed an apparent equilibrium dissociation constant (K-d) of 88.2 +/- 21.4 nM and a maximal number of binding sites (B-max) of 65.4 +/- 6.8 fmol/mg protein (mean +/- SEM, n=4). The specific binding of [I-125]CHIBA-1006 was inhibited by a number of alpha 7 nAChR-selective ligands (e.g., unlabeled CHIBA-1006, SSR180711, CHIBA-1001, MG624 and A844606), suggesting a similarity among 7 nAChR pharmacological profiles. In contrast, alpha-bungarotoxin, MLA, and nicotine showed very weak affinity for [I-125]CHIBA-1006 binding. The regional distribution of [I-125]CHIBA-1006 binding to crude membranes from dissected regions of the rat brain was different from that of [I-125] alpha-bungarotoxin binding, suggesting that [I-125]CHIBA-1006 binding sites may not be identical to [I-125]alpha-bungarotoxin binding sites in the rat brain. The present findings suggest that [I-125]CHIBA-1006 would be a useful new small molecule radioligand for alpha 7 nAChRs in the brain. (C) 2010 Elsevier B.V. All rights reserved.NeurosciencesSCI(E)2ARTICLE130-137136
An experimental study on (131)I-CHIBA-1001: a radioligand for α7 nicotinic acetylcholine receptors.
No full textOBJECTIVE: The α7 nicotinic acetylcholine receptors (nAChRs) play a vital role in the pathophysiology of neuropsychiatric diseases such as Alzheimer's disease and depression. However, there is currently no suitable positron emission tomography (PET) or Single-Photon Emission Computed Tomography (SPECT) radioligands for imaging α7 nAChRs in brain. Here our aim is to radiosynthesize a novel SPECT radioligand (131)I-CHIBA-1001 for whole body biodistribution study and in vivo imaging of α7 nAChRs in brain. METHOD: (131)I-CHIBA-1001 was radiosynthesized by chloramine-T method. Different conditions of reaction time and temperature were tested to get a better radiolabeling yield. Radiolabeling yield and radiochemical purities of (131)I-CHIBA-1001 were analyzed by thin layer chromatography (TLC) and high-performance liquid chromatography (HPLC) system. Whole body biodistribution study was performed at different time points post injection of (131)I-CHIBA-1001 in KM mice. Monkey subject was used for in vivo SPECT imaging in brain. RESULT: The radiolabeling yield of (131)I-CHIBA-1001 reached 96% within 1.5∼2.0 h at 90∼95°C. The radiochemical purity reached more than 99% after HPLC purification. (131)I-CHIBA-1001 was highly stable in saline and fresh human serum in room temperature and 37°C separately. The biodistribution data of brain at 15, 30, and 60 min were 11.05±1.04%ID/g, 8.8±0.04%ID/g and 6.28±1.13%ID/g, respectively. In experimental SPECT imaging, the distribution of radioactivity in the brain regions was paralleled with the distribution of α7 nAChRs in the monkey brain. Moreover, in the blocking SPECT imaging study, the selective α7 nAChR agonist SSR180711 blocked the radioactive uptake in the brain successfully. CONCLUSION: The CHIBA-1001 can be successfully radiolabeled with (131)I using the chloramine-T method. (131)I-CHIBA-1001 can successfully accumulate in the monkey brain and image the α7 acetylcholine receptors. (131)I-CHIBA-1001 can be a candidate for imagingα7 acetylcholine receptors, which will be of great value for the diagnosis and treatment of mental diseases
Memo from Marlin T. Kurtz to Mr. Ted Chiba and Mr. Shoji Nagumo, January 28, 1943
No full textMemorandum of understanding from Marlin Kurtz to Ted Chiba and Shoji Nagumo regarding construction in Recreation Hall 12-26 at Heart Mountain incarceration camp. "Rec. Dept. Form no. 12."The Japanese American Archival Collection documents the people, places, and daily life of Japanese Americans, primarily those who lived in the once thriving community of pre-war Florin in the Sacramento region, as well as the conditions in American incarceration camps during World War II. The approximately 7,000 original items include personal and official letters, photographs, diaries, arts and crafts, newsletters, textiles, camps artifacts, yearbooks and other publications
Paranthura oriens sp. nov. (Isopoda: Anthuroidea: Paranthuridae) from Tateyama, Chiba, Japan
No full textWe describe Paranthura oriens sp. nov. based on specimens collected from Tateyama, Chiba, Japan. Paranthura is the most speciose genus in Anthuroidea, with five groups defined by the condition of the pleonites. Our new species belongs in Group E, defined by having dorsally fused pleonites 1–5. It differs from the other 17 species in Group E in the following combination of characters: (1) the apical edge of the telson is rounded, not sharp, (2) the uropodal endopod is triangular and tapering, and (3) the uropodal exopod is narrow, 2.72–2.84 times longer than wide. We determined a partial cytochrome c oxidase subunit I (COI) nucleotide sequence for the new species
Moral instruction in budo: a study of Chiba Chosaku with a translation of his major work
No full textThis thesis provides a translation and transliteration of a late Meiji period martial arts text, Moral Instruction in Budo (1912), together with a study of its author, Chiba Chosaku (1861-1935). The aim is to contextualize Chiba's thinking in the framework of historical events and ideological currents of his time, in order to facilitate better understanding of his contribution. Chiba argued that martial arts practice (budo) is the way to maintain and transmit martial religious ethics (bushido) in the modern condition of Westernized Japan. The importance of Chiba's study lies in his claim that bushido is not a legacy of the medieval samurai class, but a due faith based on loyalty to the Emperor and patriotism toward the Japanese nation, which provides the foundation for budo practice. Chiba submits that the implementation of budo instruction at the level of national education would prevent the slackening of morals and contribute to strengthening of the Japanese national character and military institution. Chiba's career and writings demonstrate that the militarist slant in the budo ideology of Japan did not occur in the 1930s, as is generally accepted, but began at least two decades earlier. As the earliest example of a narrative that blends budo and bushido ideologies, Moral Instruction in Budō remains a crucial text for understanding the historical impact of martial arts in Japan.Cette thèse offre une traduction et une translittération d'un texte datant de la fin de l'ère Meiji sur les arts martiaux, Moral Instruction in Budo (1912), ainsi qu'une étude sur l'auteur, Chiba Chosaku (1861-1935). L'objectif visé consiste à conceptualiser la pensée de Chiba dans la perspective des événements historiques et des courants idéologiques de son époque, en vue de faciliter une meilleure compréhension de sa véritable contribution. Chiba défendait l'idée que la pratique des arts martiaux (budo) soit la manière de maintenir et de transmettre l'éthique religieuse martiale (bushido) dans la condition moderne du Japon occidentalisé. L'oeuvre de Chiba prend toute son importance lorsqu'il affirme que le bushido ne découle pas d'un héritage issu de la classe des samouraïs médiévaux, mais plutôt d'une foi récompense basée sur la loyauté en l'Empereur et sur le patriotisme envers la nation japonaise, laquelle fournit les fondements de la pratique du budo. Chiba soumet l'idée que la mise en application de l'enseignement du budo au niveau de l'éducation nationale préviendrait contre le relâchement de la morale et contribuerait au renforcement du caractère national japonais et de l'institution militaire. La carrière et les écrits de Chiba démontrent que la tendance militariste de l'idéologie budo n'a pas fait son apparition dans les années 1930, comme il est généralement accepté, mais qu'elle a débuté au moins deux décennies plus tôt. Comme il s'agit du tout premier exemple d'une narration fusionnant les idéologies budo et bushido, Moral Instruction in Budo ne laisse pas d'être un texte crucial dans la compréhension de l'impact historique des arts martiaux au Japon
Two Cases of Urinary Retention with Prostatic Abscess Drained by Transurethral Resection
No full textA 58-year-old male with alcoholic liver cirrhosis and a 58-year-old male with diabetes mellitus presented with high fever and urinary retention. Prostatic abscess was diagnosed by a computed tomography scan, which showed fluid collection in the prostate in both patients. Despite systematic antibiotic therapies, urinary retention persisted even after fever diminished. They underwent prostatic abscess drainage by transurethral resection (TUR). Urinary retention was released, and the recurrence of prostatic abscess has not been observed after TUR
Exploring Environmental Services Incentive Policies for the Philippine Rice Sector: The Case of Intra-Species Agro Biodiversity Conservation
No full textThis paper considers a hypothetical scheme of green payments to induce inter-specific agrobiodiversity in the context of Philippine rice farming. We empirically estimate a model of farmer behavior and then simulate the consequences of alternative (hypothetical) PES schemes under a fixed budget constraint. We find that, under this particular application, there is a clear trade-off between the two policy goals of enhancing biodiversity and poverty reduction. Even the totally untargeted lump-sum subsidy would have a larger poverty reduction impact than would the first-best conservation subsidy payment scheme. Therefore, policymakers would be required to strike a delicate balance between the two competing policy objectives. In addition, there is also a clear trade-off between the efficiency of targeted conservation payment and the information requirement for implementing subsidy schemes.payments for environmental services (PES); biodiversity; conservation; poverty; rice; Philippines
Litterfall, accumulation and turnover of nutrients in the forest floor of warm-temperate forests of central Japan
No full textExamined the forest floor of six subtropical/warm-temperate forests, three natural and semi-natural forests developed on contrasting topography, and Cryptomeria plantations of different ages, on Mt Kiyosumi, Chiba Prefecture. Annual input of nutrient elements to the soil through litterfall was estimated to be 63-121 kg/ha for N, 2.8-7.0 kg/ha for K, 1.1-1.7 kg/ha for Na, 45.6-131.0 kg/ha for Ca, and 10.2-28.4 kg/ha for Mg. The Abies-Tsuga forest occurred on shallow soil on a ridge, and had the greatest accumulation of nutrients on the forest floor and surface soils (0-15 cm). The amounts of nutrients accumulated in the forest floor and surface soils (0-15 cm) of the evergreen Quercus (Cyclobalanopsis)-Castanopsis forest on a crest slope and the deciduous Quercus-Cornus forest on a valley bottom were about half those of the Abies-Tsuga forest, but the latter deciduous forest developed on deep soils, and nutrients were stored in the lower soil layer (15-50 cm). Turnover times of nutrient elements in the forest floor and soil system were 1.6-10.8 yr for Ca. 3.2-15.8 yr for Na, 8.6-25.1 yr for Mg, 9.5-31.7 yr for K, and 20.3-100.9 yr for N. -from Author
Raw data for "Activation of oligonucleotide polyanions using collisions, electrons and photons in a timsOmni platform"
No full textRaw mass spectral data used to prepare the figures of the article "Activation of oligonucleotide polyanions using collisions, electrons and photons in a timsOmni platform", by Frédéric Rosu,1 Rim Chiba,1 Arjun Mani Mallika,1 Athanasios Smyrnakis,2 Jean-François Greisch,3 Dimitris Papanastasiou,2 Valérie Gabelica1*
1 School of Pharmaceutical Sciences, University of Geneva, 1205 Geneva, Switzerland.
2 Fasmatech Science & Technology, 15232 Chalandri, Athens, Greece.
3 Bruker Switzerland AG, 8117 Fällanden, Switzerland.
* Corresponding author: [email protected]
The data is organized by Table or Figure number as in the manuscript main text and supporting information
Integrating Role of Non-profit Organizations (NPOs) in Rural Tourism Development: evidence from Chiba, Japan
No full textOperators of rural tourism face various difficulties that hamper development of their activities. This paper explored the roles that NPOs play in the development of rural tourism to help operators counter such difficulties. For this purpose, the author firstly presented a conceptual framework from the perspective of institutional economics that explains why development of a rural tourism activity is often slow. It was revealed that the high marginal cost of acquiring skills in local resource management should be reduced to counter that slow development. Secondly, the author empirically evaluated the significance of NPOs through a case study in Chiba, Japan, that works to horizontally integrate stakeholders. This type of NPO provides services to ease difficulties encountered by operators by network building among stakeholders, providing training opportunities, negotiating with travel agencies, and assisting in program development in which many other stakeholders are not always proficient. This type of NPO can reduce the marginal cost of local resource management, which eventually leads to the development of rural tourism. Thus, it is expected that roles of this type of NPO will increase in the future. Partnerships with NPOs will be important in the design of policy measures for rural tourism
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