69 research outputs found
Developing, Validating and Using Internal Ratings: Methodologies and Case Studies
No full textWith a focus on practical applications of biophysical techniques, Biophysical Methods for Biotherapeutics helps formulation and analytical scientists in pharma and biotech better understand and use biophysical methods. Author Tapan K. Das links fundamental biophysics to the process of biopharmaceutical development using a chapter organization according to the steps of the drug development process. The text provides information to help organizations develop short- and long-term strategies for resource investment in biophysical research. © 2010 John Wiley & Sons, Ltd
Secure document management and distribution in an open network environment
No full textThis paper analyzes the problem of secure document management and distribution in an open network environment. Reader and author authentication, document integrity, origin, and privacy are addressed by a public-key based solution which exploits a combination of the PEM format with SSL-enhanced FTP and HTTP servers and clients. The solution is being implemented as part of a project to provide network security to the Italian public administratio
Erratum: Tahara, M., et al. Measles Virus Hemagglutinin Protein Epitopes: The Basis of Antigenic Stability. Viruses 2016, 8, 216
No full textThe authors wish to make the following change to their paper [1].[...
Un viaggio culturale attraverso le mostre fotografiche: dalla wilderness di A. Adams al parco dei divertimenti di M. Pesaresi
No full textIn this essay photography is regarded as a tool for the careful observation of the landscape, which keeps the observer’s perception through places of everyday life as well as remote places, sometimes non directly experienced. In both instances images represent landscape knowledge and documentation caught in the instant of photography shot. According to his observational point, the author offers his own “sight”. Photographic exhibitions are here described as an opportunity for carefully understanding the landscape. They take the observer to a cultural journey in which his look is led by the author with thoroughness and method, transmitting “indefinable feelings”. Their poetry remains fluctuating in the memory of the spectator, creating new geographical frontiers, new meeting spaces and differences
L'alfabeto "Osmanìa" in Somalia
No full textL'autore riferisce sulle vicende dell'alfabeto osmania, dopo le notizie fornite su di esso dal Cerulli, e dà alcuni testi in questa scrittura.Qoraagu wuxuu ka hadlayaa taariikhda farta Cusmaaniya, kaddib markii laga helay warkeeda Cerulli, iyo qoraallo ku saabsan fartan.The author reports on the history of the "osmania" alphabet, after the earlier account by E. Cerulli, and gives some texts in this writing
Role of age at diagnosis in defining potential familial nonmedullary thyroid cancer in kindreds with two affected members
No full textContext
The definition of familial nonmedullary thyroid cancer (FNMTC) in 2 or more first-degree relatives is controversial due to the high probability of observing a sporadic association when only 2 members of first-degree relatives are affected.
Objective
To evaluate the role of age at diagnosis in differentiating the true cases of FNMTC.
Design, Setting, Participants, and Main Outcome
From a group of 721 papillary thyroid cancer (PTC) patients, 95 familial PTC (FPTC) patients with 2 first-degree relatives have been identified. They were split in 2 groups: Group 1 consisted of both the proband and the affected relative, with age at diagnosis ≤ 45 years; Group 2 consisted of proband and/or the affected family member, with age at diagnosis > 45 years. The clinical-pathological features and outcome of both FPTC groups were compared with 626 sporadic PTC patients (SPTC).
Results
Familial PTC patients with age at diagnosis ≤ 45 years, compared with the matched group of sporadic PTCs, had a more frequent multifocal, bilateral, and extrathyroidal extension of tumor and showed worse outcome. No differences were found between FPTC and SPTC patients with age > 45 years. At multivariate analysis, distant metastases, American Thyroid Association (ATA) risk, and FPTC ≤ 45 years were independent predictors of outcome.
Conclusions
Based on the observation that PTC is more aggressive when the diagnosis is made in 2 family members, both with age < 45years, we suggest that the definition of FPTC in kindreds with 2 affected members should also take into account the age at diagnosis as a key element of familial cancer.
© The Author(s) 2020. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved
Environmental adjustment, academic involvement and difficulties of students with disabilities in ecuador
No full textThis study examines the state of education for disabled students in Ecuador, and includes
information obtained through interviews with select disabled undergraduate students. The author
provides recommendations for how educational institutions and individuals can better support
disabled students.El estudio examina el estado de la education para estudiantes descapacitados en Ecuador, e incluye informacion obtenida mediante entrevistas con ciertos estudiantes descapacitados a nivel universitario. El autor provee recomendaciones para que las instituciones academicas e individuos puedan apoyar mejor a estudiantes descapacitados
Multiple Amino Acid Substitutions in Hemagglutinin Are Necessary for Wild-Type MeaslesVirus To Acquire the Ability To Use Receptor CD46 Efficiently
No full textWild-type measles virus is intrinsically dual-tropic
No full textMeasles is a highly contagious disease that causes temporary and severe immunosuppression in patients. Signaling lymphocyte activation molecule (SLAM) expressed on cells of the immune system functions as a receptor for measles virus (MV). In addition to SLAM, vaccine strains of MV also use a ubiquitously expressed complement regulatory protein, CD46, as a receptor, whereas wild-type (wt) MV strains do not use this receptor. However, recent studies have indicated that SLAM is not the sole receptor for wt MV strains. These strains have an intrinsic ability to enter both immune and epithelial cells using distinct receptor binding sites in their hemagglutinin (H) protein. Recently, a clear answer was obtained through the identification of an epithelial MV receptor, nectin4, expressed at adherens junctions, thereby greatly improving our knowledge of MV receptors. It is now clear that MV specifically targets two cell types, immune cells and epithelial cells, using SLAM and nectin4, respectively. MV loses the ability to use either SLAM or nectin4 when it possesses specific mutations in the H protein. However, nectin4-blind MV still infects SLAM-positive immune cells efficiently (SLAM-tropic), and conversely, SLAM-blind MV infects nectin4-positive epithelial cells efficiently (nectin4-tropic). In this regard, MV is intrinsically dual-tropic to immune cells and epithelial cells. Although many aspects and molecular mechanisms underlying immunosuppressive effects and a highly contagious nature of MV still remain to be elucidated, analyses of physiological functions of these two receptors would provide deep insights into MV pathogenesis
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