718 research outputs found
I remember sports at Bridgeton High School
No full textAlthough Satoru Tsufura only lived at Seabrook for a year, he still contributed to Seabrook's reputation of producing outstanding athletes. In fact, Sat was the only 4-letter athlete in his graduating class at Bridgeton High School. He won a scholarhip in his senior year, and he was chosen as an all-star baseball player and was invited to play in a special baseball game against minor or major league baseball players. The Seabrook Educational and Cultural Center has been soliciting current and past residents of Seabrook Farms for an "I remember" project. Residents are asked to create narratives regarding their experiences at Seabrook Farms. These memories help preserve the history and multi-cultural heritage of Seabrook Farms
Associations of concomitant medications with immune-related adverse events and survival in advanced cancers treated with immune checkpoint inhibitors: a comprehensive pan-cancer analysis
No full textBackground: While concomitant medications can affect the efficacy of immune checkpoint inhibitors (ICIs), few studies have assessed associations of concomitant medications with the occurrence and profile of immune-related adverse events (irAEs). Methods: This study assessed associations of concomitant medication (antibiotics/proton pump inhibitors (PPIs)/corticosteroids)-based risk model termed the "drug score" with survival and the occurrence and profile of irAEs in 851 patients with advanced cancer treated with ICIs (with or without other agents). The study also assessed the survival impact of the occurrence of irAEs, using a landmark analysis to minimize immortal time bias. Multivariable Cox proportional hazard analyses were conducted for progression-free survival (PFS) and overall survival (OS). Results: The drug score classified patients into three risk groups, with significantly different PFS and OS. Notably, the score's predictive capability was better in patients treated with ICIs only than in those treated with ICIs plus other agents. The landmark analysis showed that patients who developed irAEs had significantly longer PFS and OS than those without irAEs. Generally, concomitant medications were negatively associated with the occurrence of irAEs, especially endocrine irAEs, whereas PPI use was positively associated with gastrointestinal irAEs, as an exception. Conclusions: Using a large pan-cancer cohort, the prognostic ability of the drug score was validated, as well as that of the occurrence of irAEs. The negative association between concomitant medications and irAE occurrence could be an indirect measure of the detrimental effect on the immune system induced by one or more concomitant drugs
Editorial Comment from Dr Taguchi to Demographics, management and treatment outcomes of benign and malignant retroperitoneal tumors in Japan
No full textPredicting Long-Term Effects of Infrastructure Development Projects in Continental South East Asia: IDE Geographical Simulation Model
No full textIt is important to develop a rigorous economic geography model for predicting changes in the location of population and industries across regions in the process of economic integration. The IDE Geographical Simulation Model (IDE-GSM) has been developed for two major objectives: (1) to determine the dynamics of locations of population and industries in East Asia in the long term, and (2) to analyze the impact of specific infrastructure projects on the regional economy at sub-national levels. The basic structure of the IDE-GSM is introduced in this article and accompanied with results of test analyses on the effects of the East West Economic Corridor on regions in Continental South East Asia. Results indicate that border costs appear to play a big role in the location choice of populations and industries, often a more important role than physical infrastructures themselves.Economic geography; Infrastructure development; Custom clearance
Usage of seawater system for long-term study of phytoplankton in the boreal coastal water of Hokkaido, Japan
No full textEffects of Thickness and Tensile Stress on Magnetic Properties of Grain-Oriented Electrical Steel
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The Development of Grain-oriented Silicon Steel with High Permeability : Current Trend of Mechanical Industry
No full textEffect of Surface State on Domain Structure and Core Loss of Grain-Oriented Electrical Steel with High Permeability
No full textEffect of Grain Size, Thickness and Tensile Stress on Core Loss of Grain-Oriented Electrical Steel
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