1,722,558 research outputs found

    Group photo of the CERN TSOs

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    TSO plenary session on 5 June 2025. The event is specially dedicated to all Territorial Safety officers, or TSOs, working at CERN as an opportunity to share experiences, common challenges and ideas, and to meet and exchange with other TSOs

    Tumor-suppressor-oncogene-scores (TSOS).

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    (a) Enrichment analysis using expression derived tumor-suppressor-oncogene-score (TSOS) in human tumors microarray and TCGA/GTEx RNAseq datasets for the whole candidate ortholog gene set (n = 619 and n = 637 respectively) in 1 million random samplings. The probability to find a list with TSOS score in the respective datasets equivalent to our experimentally obtained one is p = 7x10-6 and p = 0. (b) Tumor suppressor oncogene scores (TSOS) to assess gene expression of our candidate hits in malignancies of the indicated tissues compared to the corresponding normal tissues for all human orthologs of our fly hits (red line) versus the median distribution of gene expression of randomly chosen gene sets (numbers of samplings are indicated for each tumor, n = 619 genes for microarray gene sets and n = 637 for the TCGA and GTEx RNAseq data sets). Only human orthologs of all tested fly genes (S1 Table) were included to avoid bias of comparison. Positive values represent a higher expression in tumors, a negative TSOS shows a higher expression in normal tissues on average. For data on gene expression in tumors and normal tissue see S3 Table. P values are indicated for each tumor type.</p

    The diversity of design of TSOs

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    It is puzzling today to explain diversity and imperfection of actual transmission monopoly designs in competitive electricity markets. We argue that transmission monopoly in competitive electricity markets has to be analyzed within a [Wilson, R, 2002. Architecture of the power markets. Econometrica 70(4), 1299-1344] modular framework. Applied to the management of electricity flows, at least three modules make the core of transmission design: (1) the short run management of network externalities; (2) the long run management of network investment; and (3) the coordination of neighboring transmission system operators (TSOs) for cross-border trade. In order to tackle this diversity of designs of TSOs, we show that for each of these modules, three different basic ways of managing them are possible. Among the identified 27 options of organization, we define an ideal TSO. Second, we demonstrate that (1) monopoly design differs from this ideal TSO and cannot handle these three modules irrespective of the "institutional" definition and allocation of property rights on transmission, while (2) definition and allocation of property rights on transmission cannot ignore the existing electrical industry and transmission network structure: they have to complement each other to be efficient. Some conclusions for regulatory issues of TSOs are derived from this analysis of network monopoly organization.

    Strategic innovations by European electricity Transmission System Operators (TSOs) for navigating the energy transition

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    The electricity industry is undergoing far-reaching transformations. While the primary focus has been on decarbonizing supply and electrifying end uses, the challenges faced by grid operators, particularly Transmission System Operators (TSOs), have so far received less attention. TSOs play an essential role in maintaining the security and quality of electricity supply and are central to the energy transition. Despite being regulated monopolies shielded from direct competition, TSOs face numerous challenges, necessitating proactive future-proofing through investments in innovation and new technologies, organizational changes, and innovative business models. This thesis explores how TSOs approach innovation to counter these challenges, what drives their efforts, and how they see their role evolving in the future. It employs a mixed-methods approach, combining a qualitative benchmarking analysis to create a comparative assessment of TSOs' innovativeness, in-depth interviews with innovation leaders to provide more detailed perspectives, and quantitative modeling of the impact of disruptive technology on their business. In particular, it creates a comprehensive dataset of projects and initiatives being undertaken by TSOs across key technologies, identifying factors that might influence their innovativeness. It examines how TSOs perceive their evolving roles. Additionally, it conducts economic analysis on the impact of disruptive innovations like battery electricity storage. Finally, the thesis identifies strategies for future-proofing TSOs, emphasizing among others: decentralized innovation approaches, digital innovations, grid-enhancing technologies, sustainability, collaboration and integration with other network operators, alongside regulatory adaptations to support innovation and investment in new technologies. TSOs must embrace innovation to effectively drive and implement the energy transition in a timely manner, ensuring the achievement of climate goals. This necessitates strong regulatory support and strategic adaptability.Open Acces

    How do electricity TSOs embrace innovation to future-proof their role in the energy transition?

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    Access to electricity is the lifeblood of modern society. Electricity grids are undergoing transformative changes, driven mainly by decarbonization, decentralization and the integration of variable renewables. Transmission System Operators (TSOs) face increasing pressures from these changes, yet the scale and pace of innovation required to overcome them remain largely unexplored. This study uses interviews with innovation leaders at 11 European TSOs to investigate their approaches to managing the energy transition, focusing on innovation strategies, technology adoption, and future visions. We find that many TSOs adopt decentralized innovation strategies, involving business lines in defining innovation needs and exploring digital and grid technologies to improve efficiency and flexibility. TSOs are using cross-sector collaborations with various decision-making and benchmarking tools to improve performance and better manage emerging technologies like non-wires alternatives. While TSOs seek to adopt new technologies, regulatory constraints, excessive bureaucracy, technology immaturity, skills gaps, and organizational cultural inertia are raised as key barriers. We argue that proactive engagement in innovation, supported by collaboration and regulatory changes could improve TSO resilience and agility. We highlight the importance of integrating innovation into the core strategy of TSOs and the critical need to modernize regulatory frameworks, originally designed for a very different historical context, to eliminate outdated constraints and enable TSOs to more effectively future-proof their organizations

    Market coupling and the organization of counter-trading: separating energy and transmission again?

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    The horizontal integration of the energy market and the organization of transmission services remain two open issues in the restructured European electricity sector. The coupling of the French, Belgian and Dutch electricity markets (the trilateral market) in November 2006 was a real success that the inclusion of Germany to the trilateral market should soon prolong. But the extension of market coupling whether in Central Western Europe or in other European regions encounters several difficulties and the future remains far from clear. The highly meshed grid of continental Europe complicates things and it is now sometimes recognized that the penetration of wind will further exacerbate these difficulties. The nodal system could go a long way towards solving these problems, but its implementation is not yet foreseen in the EU. This paper analyzes versions of market coupling that differ by the organization of counter- trading. While underplayed in current discussions, counter-trading will become a key element of market coupling as its geographic coverage expands and wind penetration develops. We consider a stylized six node example found in the literature and simulate market coupling for different assumptions of zonal decomposition and coordination of TSOs. We show that these assumptions matter: market coupling can be quite vulnerable to the particular situation on hand; counter-trading can work well or completely fail depending on the case and it is not clear beforehand what will prevail. Our analysis relies on standard economic notions such as social welfare, Nash and Generalized Nash equilibrium. But the use of these notions is probably novel. We also simplify matters by assuming away strategic behaviour. The nodal organization is the reference first best scenario: different zonal decompositions and degrees of coordinations are then studied with respect to this first best solution.D52, D58, Q40

    Resilience and adaptation of third sector organizations (TSOs): insights from a developing economy.

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    This study investigates the resilience and adaptation strategies of Third Sector Organizations (TSOs) in Nigeria, employing a semi-structured interview methodology to explore how these entities navigate socio-economic challenges, particularly during the Covid-19 pandemic. The research highlights how TSOs integrate traditional and innovative strategies, including strategic capabilities, digital citizenship, cultural dynamics, and community engagement, to address and overcome adversities. Focusing on the resilience mechanisms within a Sub-Saharan African context, the study offers critical insights that enrich understanding and provide valuable information for TSOs, policymakers, and academics concerned with non-profit sector resilience in challenging environments

    Pengaruh Penerapan Metode Three Stay One Stray (TSOS) terhadap Kemampuan Menulis Teks Ulasan Siswa Kelas VIII MTs Nurul Yaqin Pekanbaru

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    &nbsp;Penelitian ini bertujuan untuk mengetahui pengaruh penerapan metode Three Stay One Stray (TSOS) terhadap kemampuan menulis teks ulasan pada siswa kelas VIII MTs Nurul Yaqin Pekanbaru. Penelitian ini menggunakan pendekatan kuantitatif dengan desain eksperimen semu (quasi-experiment) dan melibatkan dua kelompok, yaitu kelas eksperimen yang diterapkan metode TSOS dan kelas kontrol yang menggunakan metode konvensional. Teknik pengumpulan data dilakukan dengan tes, observasi, dan komunikasi. Hasil penelitian menunjukkan bahwa kelas eksperimen yang menerapkan metode TSOS memperoleh nilai rata-rata 77, sedangkan kelas kontrol hanya memperoleh nilai rata-rata 62. Uji hipotesis menunjukkan bahwa nilai thitung (5,415) lebih besar dari ttabel (1,667), yang berarti penerapan metode TSOS meningkatkan kemampuan menulis teks ulasan siswa
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