1,720,969 research outputs found
Metaplastic carcinoma of the breast: Treatment, results and prognostic factors based on international literature
No full textMetaplastic carcinoma of the breast (MCB) is a rare form of cancer containing mixture of epithelial and mesenchymal elements in variable combinations. Few and conflicting clinical data are available in the literature addressing optimal treatment modalities, prognosis and outcome. A retrospective study was conducted to review all patients with MCB diagnosed and treated at Breast Unit of Azienda Ospedaliera "Santa Maria" Terni - Italy between 2001/2010. The aim is to describe patient's clinic pathologic features and to analyze treatment results. Six female patients were studied. The median age was 48 years (range 14/58). The median tumor size was 9 cm. (range 3/18 cm.). Two cases (33%) were identified as purely epithelial and 4 (67%) as mixed epithelial and mesenchymal metaplasia. Hormone receptors were positive in only 2 patients. Modified radical mastectomy performed in 3 patients and 5 underwent axillary node dissection. Adjuvant chemotherapy was given to all patients and postoperative radiotherapy to 4. Four patients relapsed with median time of relapse of 12 months. MCB is an aggressive form of breast cancer associated with poor outcome, high incidence of local recurrence and pulmonary metastases. The disease tends to be estrogen/progesterone receptor negative. Tumor size has an important impact on outcome. The best treatment approach is yet to be defined
Forgotten goiter: our experience
No full textForgotten goiter is a rare disease that is defined as a mediastinal thyroid mass after total thyroidectomy. Massard, a French school author, was the first to us this term. According to literature the incidence is between 2-16%. The authors recorded their experience about four cases. Patients age is 46-56 years and three of them were female: case n. 1 was an incidental finding, case n. 2 had cervicobrachialgia, case n. 3 had persistent hyperthyroidism and case n. 4 had thyroid cancer metastases in laterocervical nodes. The time gap between thyroidectomy and reintervention was average 10 years. Diameter of masses is between 8-10 cm. Cervicotomy was enough to carry out in one case, cervicotomy and sternotomy were used in two patients. In one case it was necessary to carry out a cervicosternotomy and right posterolateral thoracotomy because the mass reached the Barety loggia and paraesofageal area. We used new devices for hemostasis and intraoperative nerve monitoring. Cases of permanent hypoparathyroidism, permanent recurrent laryngeal nerve paralysis or hemorrhage were not recognized. The surgery is mandatory after diagnosis. The choice of the type surgery way is conditioned by the relationships that the pathological tissue has with the mediastinal structures and exact location in that area. Surgical management for forgotten goiter in specialized centers is associated with low morbility
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Approach to lymph node metastases in sporadic medullary thyroid carcinoma. An istitutional experience
No full textAnalyse the impact of aggressive surgical treatment with accurate lymphadenectomy in medullary thyroid carcinoma
Current indications for surgical treatment of primary hyperparathyroidism in the elderly
No full textThis study presents the results of surgery in the elderly for primary hyperparathyroidism (PHPT) from a single institution's experience. We retrospectively analyzed 898 cases of surgically treated PHPT, divided into two groups: 135 elderly patients (A) and 763 patients younger than 65 years (B). PHPT was symptomatic in 68.8 per cent patients in group A and in 81.6 per cent in group B. Unilateral temporary recurrent laryngeal nerve palsy was observed in 0.9 per cent in group A and 0.1 per cent in group B (P > 0.05). No cervical hematomas, mortality or major cardiovascular, neurological, respiratory or metabolic postoperative complications were registered. All the patients evaluated at one year had improvement in the quality of life, with increase of bone mineral density (BMD) in 85.6 per cent and 79.8 per cent of patients in groups A and B, with no significant differences between symptomatic and asymptomatic patients. Parathyroidectomy in elderly PHPT patients is safe, with rate of morbidity similar to what observed in younger individuals. Further investigations are recommended to confirm the role of surgery as an effective approach in elderly PHPT patients
Breast cancer and reconstruction: can surgical technique, reconstructive time and adjuvant treatment influence the result?
No full textINTRODUCTION: Some techniques for the total reconstruction of the breast, regardless of the complexity, have specific complications, with varying degrees of morbidity. Therefore, we wanted to identify the most frequent complications of the main techniques used for breast reconstruction, and compare the relation to the relevant independent variables. METHODS: Our study was conducted by examining the medical record of patients who had received complete reconstruction of the breast after a mastectomy due to breast cancer from January 2008 to December 2010, with a minimum follow-up of 3 years postoperatively. The data collected, such as the time of intervention, reconstruction techniques, operating time, and adjuvant treatment, were statistically correlated to the presence of complications. RESULTS: Of the 40 total breast reconstructions analyzed, the technique in which they were used expanders followed by replacement with implants showed the lowest prevalence of complications (1 6 7%, p < 0.000). Some surgical techniques have shown particular complications. The operative time for transplant transverse rectus abdominis musculocutaneous flap (363.57 ± 59.91 nin) was significantly higher than that required for the techniques that use allophtic materials (155.71 ± 38.02 min, p = 0, 01), but similar to that for the latissimus dorsi flap (309.69 ± 77.66 rnin). The operative time, the timing of reconstructive surgery, and type of adjuvant treatment was not correlated with the incidence of complications. CONCLUSIONES: Each technique has its indications, contraindications and complications. The application of each technique must be tailored to the individual characteristics of each patient
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Approach to lymph node metastases in sporadic medullary thyroid carcinoma: An istitutional experience
No full textAIM: Analyse the impact of aggressive surgical treatment with accurate lymphadenectomy in medullary thyroid MATERIALS AND METHODS: We retrospectively analysed 152 patients affected by medullary thyroid carcinoma, divided two groups, considering outcome and surgical complications. RESULTS: Primary surgical treatment with thyroidectomy plus central and lateral neck dissection, offers significant reduction in post-operative calcitonin levels, reduced recurrences and limited complications. DISCUSSION: Accurate lymphadenectomy, according to the international guidelines and the main results of clinical studies is the only treatment combined to total thyroidectomy which offers improved outcome in medullary thyroid carcinoma since inejficacy of chemotherapy and radiotherapy. CONCLUSIONS: Surgery is the unique and fundamental therapy for patients affected by medullary thyroid carcinoma. Extended neck dissection combined to precocious diagnosis and strict follow-up might be considered the standard of treatment medullary thyroid carcinoma
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
- …
