46,671 research outputs found
Rauschiella linguatula Travassos 1924
No full textRauschiella linguatula (Rudolphi, 1819) Travassos, 1924 Hosts (prevalence; range): B. raniceps (1/79; 1) and L. chaquensis (2/143; 2–3). Site of infection: small intestine. Stage: adult. Type host and type locality: L. latrans (= L. ocellatus), Brazil. Comments: Rauschiella linguatula was described as Distoma linguatula by Rudolphi (1819). However the description was very superficial and Travassos (1924) improved details in a second description as Glypthelmins linguatula. After, Razo-Mendivil et al. (2006) integrating molecular data and scanning electron micrographs recombined some species of Glypthelmins as Rauschiella, including R. linguatula, by a set of characters such as small spines in the tegument, dextral ovary, cirrus sac with coiled seminal vesicle, Y-shaped excretory vesicle and vitelline follicles predominantly extracaecal. The small spines in tegument were not verify in our specimens because we did not undertake scanning electron micrographs; however, we observed the following features of R. linguatula: wide pharynx, small acetabulum, uterus intercaecal with one or two loops on the caeca and other loops passing between testes, posterior region filled with uterine loops which reach the end of the body after the end of caeca, and a notable subterminal excretory pore with radial ornamentation (Travassos 1924). Rauschiella linguatula is widely distributed in anurans from South America (Argentina, Bolivia, Brazil, Uruguay, and Venezuela) (see Kohn & Fernandes 2014), however, this is the first report in B. raniceps.Published as part of Aguiar, Aline, Morais, Drausio Honorio, Firmino Silva, Lidiane A., Anjos, Luciano Alves Dos, Foster, Ottilie Carolina & Silva, Reinaldo José Da, 2021, Biodiversity of anuran endoparasites from a transitional area between the Atlantic Forest and Cerrado biomes in Brazil: new records and remarks, pp. 1-41 in Zootaxa 4948 (1) on page 22, DOI: 10.11646/zootaxa.4948.1.1, http://zenodo.org/record/461606
Antibodies as Crypts of Antiinfective and Antitumor Peptides
No full textAntibodies (Abs), often associated with antimicrobial and antitumor agents, have emerged as an important class
of novel drugs for antigen-driven therapeutic purposes in diverse clinical settings, including oncology and infectious diseases.
Abs commonly give rise in the treated host to anti-Ab responses, which may induce adverse reactions and limit their therapeutic efficacy. Their modular domain architecture has been exploited to generate alternative reduced formats (Fabs, scFvs, dAbs, minibodies, multibodies), essentially devoid of the Fc region. The presence of complementarity determining regions (CDRs) ensures the maintenance of selective binding to antigens and supports their use for biotechnological and therapeutic applications. Paradigmatic Abs mimicking the wide-spectrum antimicrobial activity of a yeast killer toxin (killer Abs) have revealed the existence of a family of Abs exerting a direct in vitro and/or in vivo microbicidal activity. Based on the variable sequence of an antiidiotypic recombinant killer Ab, CDR-related peptides have been synthesized, engineered by alanine-scanning and selected according to antimicrobial, antiviral and immunomodulatory properties.
Irrespective of the native Ab specificity, synthetic CDRs from unrelated murine and human monoclonal Abs, have shown to display differential in vitro, in vivo and/or ex vivo antifungal (Candida albicans), antiviral (HIV-1) and antitumor (melanoma cells) activities. Alanine substitution of single residues of synthetic CDR peptides resulted in further differential increased/unaltered/decreased biological activity. The intriguing potential of Abs as source of antiinfective and antitumor therapeutics will be discussed, in light of recent advances in peptide design, stability and delivery
Schooling and education.
No full textSchooling and education by Giles R. Wright with Howard L. Green and Lee R. Parks. Number 4 in the New Jersey Ethnic Life Series. Published by New Jersey Historical Commission
Rhadinorhynchidae Travassos 1923
No full textFamily Rhadinorhynchidae Travassos, 1923 Gorgorhynchus trachinotus Noronha, Vicente, Pinto & Fábio, 1986 —adult Host and habitat: Trachinotus goodei (MAR) Locality: Off Rio de Janeiro Reference: Noronha et al. (1986) Gorgorhynchus sp.—adult and larva Hosts and habitat: Dactylopterus volitans (MAR—adult), Dipturus trachyderma (MAR—larva), Pinguipes brasilianus (MAR—adult) new record, Pseudopercis numida (MAR—adult), Sphyrna zygaena (MAR—larva), Squatina sp. (MAR—larva) Localities: Off Rio de Janeiro, off Rio Grande do Sul, off Paraná, off Santa Catarina References: Knoff et al. (2001), Cordeiro and Luque (2005), Luque et al. (2008) Rhadinorhynchus plagioscionis Thatcher, 1980 —adult Host and habitat: Plagioscion squamosissimus (FW) Locality: Amazon River basin Reference: Thatcher (1980, 1991) Rhadinorhynchus pristis (Rudolphi, 1802) —adult Hosts and habitat: Coryphaena hippurus (MAR), Balistes vetula (MAR), Euthynnus alletteratus (MAR), Katsuwonus pelamis (MAR), Auxis thazard (MAR), Scomber japonicus (MAR) Locality: Off Rio de Janeiro References: Rudolphi (1819), Abdallah et al. (2002), Mogrovejo and Santos (2002), Alves et al. (2003, 2005), Alves and Luque (2006), Oliva et al. (2008) Rhadinorhynchus sp.—adult Hosts and habitat: Dactylopterus volitans (MAR), Merluccius hubbsi (MAR) (new record), Paralonchurus brasiliensis (MAR) Locality: Off Rio de Janeiro References: Ribeiro et al. (2002), Luque et al. (2003), Cordeiro and Luque (2005) Serrasentis sp.—larva Hosts and habitat: Balistes capriscus (MAR), Haemulon steindachneri (MAR), Oligoplites palometa (MAR), Orthopristis ruber (MAR), Paralonchurus brasiliensis (MAR), Parona signata (new record) (MAR) Locality: Off Rio de Janeiro References: Luque et al. (1995, 1996a, b, 2003), Takemoto et al. (1996), Luque and Poulin (2004), Alves et al. (2005)Published as part of Santos, Cláudia P., Gibson, David I., Tavares, Luiz E. R. & Luque, José L., 2008, Checklist of Acanthocephala associated with the fishes of Brazil, pp. 1-22 in Zootaxa 1938 on pages 5-6, DOI: 10.5281/zenodo.18499
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
De Maiestate / Praeside M. Jacobo Thomasio, Moralis Philosoph. P. P., publice disputabit Johannes Dunte, R. L. Author & Respon: ad diem 9. Septembr. H L. Q. C.
No full textDE MAIESTATE / PRAESIDE M. JACOBO THOMASIO, MORALIS PHILOSOPH. P. P., PUBLICE DISPUTABIT JOHANNES DUNTE, R. L. AUTHOR & RESPON: AD DIEM 9. SEPTEMBR. H L. Q. C.
De Maiestate / Praeside M. Jacobo Thomasio, Moralis Philosoph. P. P., publice disputabit Johannes Dunte, R. L. Author & Respon: ad diem 9. Septembr. H L. Q. C. (1)
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"Closing the R&D Gap, Evaluating the Sources of R&D Spending"
No full textBoth spending and tax policies have been implemented in the United States with the goal of stimulating private sector research and development (R&D). Karier questions whether current R&D policy, especially the research and experimentation tax credit, can contribute to closing the gap between nondefense expenditures on R&D in the United States and such expenditures in other countries, such as Japan and Germany. He also explores possible changes to our current R&D policy to make it more effective.
Antibodies are cryptic reservoirs of antiinfective, antitumor and immunomodylatory peptides
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