1,645 research outputs found
I film, scenari del Toti-Verso
No full textI film amatoriali e di famiglia di Gianni Toti e Marinka Dallo
TUMOUR MICROENVIRONMENT: PROTEIN MEDIATORS OF INTERCELLULAR CROSSTALK
No full textTumor progression is not only due to the aggressiveness of cancer cells but also to the support given by tumour reactive stroma; reason why the study of stromal cell involvement in tumor microenvironment has become extremely important in the last decades. Tumor mass is a complex network of cancer and stromal cells, and fibroblasts are the main component. Under the influence of tumor cells, fibroblasts engage a transdifferentiation program converting them into their active form (myofibroblast), the so called cancer associated fibroblasts (CAFs), that, in turn, are able to enhance tumor cells growth, migration and invasion. This crosstalk is mediated by soluble factors, cell–cell contacts and extracellular vesicles (EVs) trafficking. Our work is focused in particular on cellular interaction based on EVs trafficking. Two types of Evs has been described, ectosomes (with a diameter from 100 nm to 1 μm) and exosomes (from 30 to 100 nm) that show differences in size, biogenesis and composition. It has been discovered by my research group that a transfer of proteins and lipids between CAFs and cancer cells mediated by ectosomes exists and that this is, essentially unidirectional from CAFs to cancer cells. We have identified about two hundreds proteins that are specifically transferred to cancer cells by this type of cargo. One of the most interesting proteins, considering its role in cancer progression is Galectin-1 We have found that Galectin-1 silencing in CAFs reduce the migration of cancer cells, revealing a novel mechanism by which tumor stroma contribute to cancer progression. These results are important because Galectin-1 has been highlighted as a good target in both cancer and fibroblast cells, increasing the possibilities to counteract cancer aggressiveness by reducing Galectin- 1 action through specific inhibitors.
In the second part of my thesis the role of low molecular weight protein tyrosine phosphatase (LMW-PTP) in fibroblasts during their activation has been investigated for the first time. It is known that LMW-PTP expression in cancer increases with the staging of tumor and that it is implicated in several biological processes. Our findings show that the activation induces in CAFs an increase of LMW-PTP expression that is associated to cytoskeletal rearrangement. As a consequence CAFs show a more invasive phenotype that is reversed when LMW-PTP is silenced. Additionally our results suggest the LMW-PTP involvement in cell metabolism. The increase of LMW- PTP induces a more gycolytic metabolism and its silencing causes the induction of a more OXPHOS behaviour. We hypothesize that LMW-PTP could drive fibroblast infiltration and migration during tumor progression.
These findings, taken together, contribute to highlight the role of CAFs within tumor microenvironment in sustaining tumors
Creare le cose da vedere. Gianni Toti e il video, macchina da poesia
No full textsul videoartista italiano Gianni Toti nel contesto internazional
Between Cinema and Poetronic (and beyond)
No full textUn saggio dedicato al poeta e artista video italiano Gianni Toti, soprattutto per quanto riguarda il suo rapporto con il cinema. An essay about the italian poet and video-artist Gianni Toti, mainly on his dialogue and tribute to cinema
Lettera di Alessandra
No full textUn ritratto critico dell'opera di Alessandra Carnaroli, autrice fra le più apprezzate delle ultime generazioni della poesia di ricerca. La sezione a lei dedicata, nel numero della rivista, contiene inoltre saggi di Cecilia Bello Minciacchi, Andrea Cortellessa, e Ivan Schiavone; e vari inediti dell'autrice. Il saggio è pubblicato con lo pseudonimo di Tommaso Ottonieri.A critical portrait of the work of Alessandra Carnaroli, author of the most appreciated in the latest generations of italian research poetry. Published under the pseudonym Tommaso Ottonieri
Selected letters of Alessandra Strozzi
No full textThe letters of Alessandra Strozzi provide a vivid and spirited portrayal of life in fifteenth-century Florence. Among the richest autobiographical materials to survive from the Italian Renaissance, the letters reveal a woman who fought stubbornly to preserve her family's property and position in adverse circumstances, and who was an acute observer of Medicean society. Her letters speak of political and social status, of the concept of honor, and of the harshness of life, including the plague and the loss of children. They are also a guide to Alessandra's inner life over a period of twenty-three years, revealing the pain and sorrow, and, more rarely, the joy and triumph, with which she responded to the events unfolding around her.This edition includes translations, in full or in part, of 35 of the 73 extant letters. The selections carry forward the story of Alessandra's life and illustrate the range of attitudes, concerns, and activities which were characteristic of their author
Challenging the author: Gavin Douglas's Eneados
No full textGavin Douglas’s Eneados, a translation into the “Scottis” tongue of Virgil’s Aeneid, completed in 1513 and first published in London in 1553, presents, as well as the translation of the additional thirteenth book by Maphaeus Vegius, original prologues and marginal notes to the text, rubrics and articulate conclusive material. The present paper analyses this complex paratext as evidence of Douglas’s almost philological attention to the original and his preoccupation with a faithful reproduction; it is also suggested that the models for his organization of the commentary might be both medieval (i.e., manuscripts such as Petrarch’s Virgilius Ambrosianus) and early modern, as in the case of editions of classical works: the most apt example being Jodocus Badius Ascensius’ edition of the Aeneid, printed in 1501. The Eneados thus stands on the threshold between manuscript and print, and might have indicated new possibilities of use of the printing medium in Scotland, and of the value of the translation of a classical text, had history not intervened with the Scottish defeat at Flodden Fields in 1513, which put a temporary stop both to the circulation of the Eneados and to the development of Scottish printing
Un canto alla vita. "La morte del trionfo della fine", videopoema di Gianni Toti
No full textIl tema della tesi è inerente l'analisi dell'ultimo video dell'artista Gianni Toti dal titolo: "La morte del trionfo della fine". Il lavoro, partendo dalle prime opere dell'artista, descritte con il supporto di alcuni testi monografici e critici, ha preso in esame il tema ispiratore dell'ultima opera e, con l'ausilio di alcuni testi storico artistici e letterari, è giunto all'illustrazione di alcune ipotesi al riguardo
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