106,452 research outputs found
Mgr Tihamer Toth, Le symbole des apôtres, 1935 ; T. Burger, Le prédicateur des enfants ; Cl. Oberhammer, Nouveau recueil d'exemples
No full textVansteenberghe Edmond. Mgr Tihamer Toth, Le symbole des apôtres, 1935 ; T. Burger, Le prédicateur des enfants ; Cl. Oberhammer, Nouveau recueil d'exemples. In: Revue des Sciences Religieuses, tome 15, fascicule 4, 1935. pp. 639-640
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
The particle spectrum of the Tricritical Ising Model with spin reversal symmetric perturbations
No full textPam3Cys4 internalization by naïve CD4+T cells accelerates t-bet promoter epigenetic modification and restrains TGF–β1 expressing tumor growth (P2153)
No full textPam3Cys4 internalization by naïve CD4+T cells accelerates t-bet promoter epigenetic modification and restrains TGF–β1 expressing tumor growth (P2153)
Mohsen Ibrahim,1,3Kelsey Toth,1Donatella Ponti,4Antonella Calogero,4Claudio Andreetti,3Howard Huang,2Daniel Kreisel,1Sasha Kreisel,1Erino Rendina,3 and Andrew Gelman1,3
1Surgery, Washington Univ. in St. Louis, St. Louis, MO 2Medicine, Washington Univ. in St. Louis, St. Louis, MO 3Thoracic Surgery, Sapienza University of Rome, Rome, Italy 4Pathology, Sapienza University of Rome, Rome, Italy
To promote Th1 responses TLR2 engagement is conducted on ex vivo-activated T cells but this hinders Ag-specific clonal expansion in vivo. We asked if naive CD4+T cells could internalize the TLR2 agonist Pam3Cys4 to promote Th1 responses in vivo. Methods: WT, TLR2-/- or OT2 CD69-CD25-CD44-CD62L+CD4+T cells were incubated with rhodamine-labeled or unlabeled Pam3Cys4 for 3 hrs and extensively washed to remove all soluble agonist. CD4+T(iPam) activation ex vivo was conducted under Th1 conditions +/- TGF-β1 and bisulfite conversion t-bet promoter sequence analysis was performed. 4x10(5) OT2 or OT2(iPam) cells were adoptively transferred into B6 mice with established EG-7 OVA tumors. Results: Intracellular FACS revealed WT or TLR2-/- CD4+T cells readily internalize Pam3Cys4. As compared to untreated CD4+T cells CD4+T(iPam) displayed > than 50% t-bet promoter CpG hypomethylation at -134 and -75 at 36 hrs post-activation leading to sharply higher t-bet and IFN-{gamma} expression in a TLR2 dependent manner. OT2 (iPam) halted EG-7 OVA growth with high numbers of OVA-specific CD4+ and CD8+ T cells in the DLN and tumor. In contrast, untreated OT2 induced little Th1 accumulation and accelerated tumor growth when compared to mice that did not receive T cells but this rapid growth pattern could be reversed with TGF-β1 Abs. Also, unlike with untreated OT2 cells TGF-β1 could not block naïve OT2(iPam) differentiation into Th1 cells. These data suggest a novel approach to tumor immunotherapy
Insights into flood-dominated fan-deltas: Very high-resolution seismic examples off the Amalfi cliffed coasts, eastern Tyrrhenian Sea
No full textA high-resolution (IKB-Seistec) seismic survey calibrated with gravity-core data, off the Amalfi coast, a rocky coastal area on the southern side of the Sorrento Peninsula (Italy), documents the internal stratigraphic architecture of a series of small fan-deltas that develop at the mouth of major bedrock streams. The fan-delta system mostly postdates the Plinian eruption of Vesuvius of AD 79 and displays various phases of development associated with periods of high sediment supply from the adjacent river basins. During these periods landscape-mantling loose pyroclastic deposits (mostly air-fall tephra from Vesuvius) were quickly eroded and delivered to the continental shelf by sheet wash and flash flood events. Depositional processes on the foresets were dominated by sediment gravity flows originating from hyperpycnal river flow and pyroclastic fall deposits. This in turn created favourable conditions for sea-floor instability, soft sediment failure, slumping and sliding, which characterize the deltaic stratigraphic architecture. The intermittently increased sediment yield during the various phases of the evolution of the fan-delta system was probably influenced also by the morphoclimatic regime. This may have resulted in varying rates of progradation of the delta foresets, tentatively correlated with the main climatic oscillations of the last 2000 years. The Amalfi fan-delta system represents a small-scale analogue for larger flood-dominated fan-deltas of the world and may be regarded as a useful example for a better understanding of inner-shelf, mixed siliciclastic-volcaniclastic fan-delta systems in the stratigraphic record. © The Geological Society of London 2009
Reflecting on words: the formation of words in the Invalsi tests
No full texthe present study examines the word formation tasks administered in Careful attention is reserved to the topic of tex translation within th the language awareness section of the Invalsi tests, starting from 2008, field of linguistics. However, t is true that he tr nslation of cassic the first year when the tests were administered, up to 2019. The objeclanguages, widely considered as dead languages", s still unexplored tive of this revision is to gain a deeper understanding of 1) which word This study is based on the syntactic and lexical analysis of scholasti formation processes (e.g., derivation, composition, conversion, etc.) are translations from Latin by high school students a d proposes to outlin put under scrutiny in the tasks; 2) how the tasks are distributed between the patterns of this typology of texts The research intends to demon school levels and levels of difficulty; 3) which variables affect task difstrate how the linguistic code derived from these texts differentiates it ficulty; 4) if the test results allow for the identification of a progression self from the common written and spoken Italian and thus is based on of topics, from the easiest to the most difficult. The analyses reveal that own and artificial norms that make this textual production a simpl most of the tasks investigate the process of derivation and that their diftranslation exercise rather than the creation of a self-standing and au ficulty is influenced by the interaction of several variables. The most tonomous text. Secondly, these patte ns are an lyzed and compare salient variables are the complexity of the task (number of words to with contact language (pidgins, interlanguage) and with a technical an analyse and the format), the degree of abstraction required by the quesguage, scholastic Italian. tion and the frequency of the words to analyse
Handwritten biographical information on Paulina T. McClung Merritt
No full textA handwritten biography of Paulina T. McClung Merritt by an unknown author, 1892.
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
No full textIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
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