1,720,965 research outputs found
Serum levels of inhibin B and FSH in patients with and without microdeletions of the Y chromosome long arm
No full textCOMPORTAMENTO SESSUALE, IMPREGNAZIONE STEROIDEA E CERVELLO FETALE: IL MODELLO DEI TRANSESSUALI.
No full textHormone and genetic study in male to female transsexual patients
No full textBackground: Data of the literature demonstrated controversial results of a correlation between transsexualism and genetic mutations. Aim: To evaluate the hormone and gene profile of male-female (M-F) transsexual. Subjects and methods: Thirty M-F transsexuals aged 24-39. Seventeen had already undergone sex reassignment surgery, 13 were awaiting. All subjects had been undergoing estrogen and antiandrogen therapy. We studied hormones of the hypothalamus-pituitary-testicular axis, thyroid and adrenal profile, GH basal and after GHRH stimulation, IGF-I. The gene study analyzed SRY, AR, DAX1, SOX9, AZF region of the Y chromosome. Results: Pre-surgery subjects had elevated PRL, reduced testosterone and gonadotropins. Post-surgery subjects showed reduced androgens, a marked increase in LH and FSH and normal PRL. Cortisol and ACTH were similar to reference values in pre- and post-surgery patients. There was a marked increase in the baseline and post-stimulation GH values in 6 of the 13 pre-surgery patients, peaking at T15. IGF-I was similar to reference values in both groups except for one post-surgery patient, whose level was below the normal range. There were no polymorphisms in the amplified gene region for SOX9, and a single nucleotide synonimous polymorphism for DAX1. No statistically significant differences were seen in the mean of CAG repeats between controls and transsexual subjects. SRY gene was present in all subjects. Qualitative analysis of the AZFa, AZFb, and AZFc regions did not reveal any microdeletions in any subject. Conclusions: This gender disorder does not seem to be associated with any molecular mutations of some of the main genes involved in sexual differentiation. (C) 2013, Editrice Kurti
Dietary Intervention and Nutritional Counseling
No full textThe dietary treatment for weight loss in overweight and obesity has been approached in many different dietary models. Nevertheless, beside the size of weight loss, the main outcomes should be mostly the improvement of body composition (loss of body fat and preservation of lean body mass), long-term maintenance, nutritional quality of the diet, lower risk for chronic diseases (better metabolic parameters), improvement in quality of life and psychological well-being. The most popular diets have been analyzed: High protein diets (HPD); Low-carbohydrate diets (LChoD) and Low Glycaemic Index or Load diets (LGID); Low-Fat diets (LFD); Low Calorie Diet (LCD) and Very low-calorie diet (VLCD); Ketogenic diets (KD). In the end, the criteria for the development of a balanced dietary treatment in obese patient are discussed as a result of a critical analysis of the different dietary patterns described. Several evidences lead to the conclusion that the Mediterranean dietary pattern better respects the clinical guidelines for overweight and obesity treatment. In order to achieve a good compliance and the subsequently long-term results, the multidisciplinary approach, based on nutritional counseling, physical activity, together with the cognitive-behavioral therapy, is the only reasonable therapeutic option
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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