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ABSENCE OF AN OPIOID STIMULATORY TONE ON GROWTH HORMONE SECRETION IN WOMEN WITH MICROPROLACTINOMA
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HIGH PREVALENCE OF ANTIBODIES TO HELICOBACTER PILORI IN PATIENTS WITH AUTOIMMUNE THYROIDITIS. COULD HP INFECTION PLAY A ROLE AS A TRIGGERING AGENT OF AUTOIMMUNITY?
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Lack of correlation between gastrointestinal symptoms and Helicobacter pylori infection in children
No full textThe effect of acute bladder filling on plasmatic antidiuretic hormone production in healthy adult volunteers
No full textObjective: To assess the existence of a vesical hypothalamic reflex by evaluating the changes of plasmatic ADH levels during acute bladder filling in healthy adult volunteers. Materials and Methods: Twenty normal male subjects aged between 19 and 40 years (average age 31.6 years) were evaluated. All subjects signed informed consent. The subjects had no pathologic blood and urine examination, no cardiovascular, hepatic, renal disease, they were no smokers and they did not take drugs which may interfere with plasmatic ADH levels. A blood sampling at rest condition (time 0) and successively during cystometry in the presence of first sensation, normal and strong desire was carried out. Plasmatic ADH was measured on extracted samples by radioimmunoassay. A one-factor repeated measures analysis of variance was employed to verify the effect of time on ADH levels. The Greenhouse-Geisser and Huynh-Feldt adjustments were adopted to protect against the case of violation of homogeneity of covariance. Results: Statistical analysis did not show significant differences of plasmatic ADH levels between rest condition and bladder filling. Conclusions: We exclude the existence of a vesical hypothalamic reflex and we suppose that extravesical factors may interfere with the plasmatic ADH production during the night
Is there anything to the reported association between Helicobacter pylori infection and autoimmune thyroiditis?
No full textHigher serological prevalence rates of Helicobacter pylori (Hp) infection have been reported in patients with autoimmune thyroiditis (AT), and it has been suggested that monoclonal antibodies against Cag-A positive Hp strains can cross-react with follicular cells of the thyroid gland. We studied the prevalence of AT and thyroid functional status in patients who underwent gastroscopy for dyspeptic symptoms. Patients were tested for TSH, free thyroid hormones, and antithyroglobulin and antithyroperoxidase antibodies (ATPO). Hp positivity was determined using urea breath test (UBT). Serum samples from 302 patients (59.9% women) were evaluated. One hundred ninety-one subjects (63.2%) were Hp-negative, and 111 of 302 (36.8%) were Hp-positive. Forty-three of 191 Hp-negative patients (22.5%; 95% CI, 17.1-29.0%) had an increase of either antibody, compared to 30 of 111 (27.0%; 95% CI, 19.6-36.0%) Hp-positive patients (P = 0.40). Similar results were obtained using positivity for both antibodies (7.3 vs. 7.2%; P = 1) or for ATPO (18.8 vs. 21.6%; P = 0.54). The prevalences of hypothyroidism (4.7 vs. 5.5%) or hyperthyroidism (5.8 vs. 5.5%) were also similar (P = 0.95). Hormonal levels were not different in the two groups (P > 0.22 in all cases). The previously reported association between AT and Hp infection was not observed in our study. Infection by Hp does not appear to increase the risk of AT in individuals with dyspeptic symptoms, and screening for this condition in patients with a positive UBT is not indicated
SCREENING FOR CELIAC DISEASE IN PATIENTS WITH AUTOIMMUNE THYROID DISEASE: FROM RESEARCH STUDIES TO DAILY CLINICAL PRACTICE
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