15 research outputs found
The Effect of Breed, Sex, Age and Race Type on Racing Performance and Blood Myostatin, Irisin, Erythropoietin Levels in Thoroughbred and Arabian Horses
No full textAmaç: Bu çalışma, İngiliz ve Arap atlarında ırk, cinsiyet, yaş ve yarış tipi gibi bazı biyolojik ve çevresel faktörlerin; kandaki miyostatin, irisin ve eritropoetin düzeyleri ile yarış performansı üzerindeki etkilerini saptamak amacına yönelik olarak yapılmıştır.
Gereç ve Yöntem: Çalışma, Türkiye Jokey Kulübü İzmir Şirinyer Hipodromu'nda düzenlenen resmi yarışlara katılan 176 yarış atı (88 İngiliz Atı, 88 Arap Atı) üzerinde yürütülmüş ve atlardan yarış öncesi alınan kan örneklerinden elde edilen serumda miyostatin, irisin ve eritropoetin düzeyleri ELISA yöntemi ile belirlenmiştir. Atların yarış performansına ilişkin veriler Türkiye Jokey Kulübü veri tabanından elde edilerek; pist tipi, pist uzunluğu, yarış yaşı, dereceye girme durumu ve mevsim faktörlerinin hız, miyostatin, irisin ve eritropoetin düzeyleri üzerine etkileri genel doğrusal model yöntemi ile analiz edilmiştir.
Bulgular: Bu çalışmada elde edilen bulgular, İngiliz ve Arap atları arasında yarış performansı açısından istatistiksel olarak anlamlı bir fark bulunduğunu, ancak aynı ırk içerisindeki cinsiyet farklılıklarının performans üzerinde belirgin bir etki oluşturmadığını ortaya koymuştur. Pist tipinin hız faktörü üzerinde etkili olduğu; çim pistte koşan atların, kum pistte koşanlara göre daha yüksek hız değerlerine ulaştığı saptanmıştır. Miyostatin düzeyleri, dereceye giren atlarda anlamlı biçimde daha yüksek saptanmış ve bu miyokinin performansla ilişkili olabileceğine dair önemli ipuçları sunmuştur. Miyostatin ve irisin konsantrasyonlarının mevsimsel değişkenlik gösterdiği ve bu farklılıkların istatistiksel olarak anlamlı düzeyde olduğu belirlenmiştir. İrisin düzeyleri de çevresel faktörlerden etkilenmiş; özellikle çim pistte koşan atlarda daha yüksek düzeyler gözlemlenmiş ve bu fark istatistiksel olarak anlamlı bulunmuştur. Eritropoetin düzeyleri açısından gruplar arasında sayısal farklılıklar gözlense de bu farklar istatistiksel olarak anlamlılık düzeyine ulaşmamıştır. Ayrıca yarış yaşına bağlı olarak hız ve irisin düzeylerinde anlamlı farklılıklar saptanmış; miyostatin düzeylerinde ise istatistiksel anlamlılık elde edilememekle birlikte dikkat çekici sayısal farklılıklar belirlenmiştir.
Sonuç: Bu çalışma, İngiliz ve Arap atlarında ırk, cinsiyet, yaş ve yarış tipi gibi biyolojik ve çevresel değişkenlerin yarış performansı ile kandaki miyostatin, irisin ve eritropoetin düzeylerine etkisini inceleyen özgün bir araştırmadır. Elde edilen bulgular, yaşın hız ve bazı biyobelirteç düzeyleri üzerinde anlamlı etkiler oluşturduğunu; miyostatin ve irisin düzeylerinin mevsim, pist tipi ve performans durumu gibi faktörlere duyarlı olduğunu göstermiştir. Ayrıca miyostatin ve irisin arasında anlamlı pozitif bir ilişki bulunması, bu iki myokinin egzersiz fizyolojisindeki ortak regülasyonunu düşündürmektedir. Elde edilen sonuçlar, yarış atlarının fizyolojik durumlarının daha iyi anlaşılması ve performansın biyobelirteç temelli değerlendirilmesi açısından önemli katkılar sunmaktadır. Çalışma, bu alanda Türkiye’de yapılan ilk kapsamlı araştırmalardan biri olması nedeniyle literatüre özgün değer katmaktadır.
Anahtar Sözcükler: İngiliz Atı, Arap Atı, yarış performansı, hız, miyostatin, irisin, eritropoetinAydın Adnan Menderes Üniversitesi, Bilimsel Araştırma Projeleri BirimiİÇİNDEKİLER
TEŞEKKÜR i
İÇİNDEKİLER iii
SİMGELER VE KISALTMALAR DİZİNİ viii
RESİMLER DİZİNİ x
TABLOLAR DİZİNİ xi
ÖZET xiii
ABSTRACT xv
1. GİRİŞ 1
2. GENEL BİLGİLER 3
2.1. Türkiye’deki At Varlığı ve At Yarışları 5
2.2. At Yarışlarında Kullanılan At Irkları 10
2.2.1. İngiliz Atı 10
2.2.2. Arap Atı 12
2.3. Yarış Performansı 13
2.3.1. Yarış Performansını Etkileyen Faktörler 14
2.3.1.1. Genotip 15
2.3.1.2. Yaş 17
2.3.1.3. Cinsiyet 17
2.3.1.4. Ana Yaşı 20
2.3.1.5. Yarış Mesafesi 23
2.3.1.6. Pist Tipi ve Hava Koşulları 24
2.4. Miyostatin 25
2.5. İrisin 28
2.6. Eritropoetin 32
3. GEREÇ ve YÖNTEM 35
3.1. Gereç 35
3.1.1. Hayvan Materyali 35
3.2. Yöntem 36
3.2.1. Örneklerin Alınması ve İşlenmesi 36
3.2.2. Laboratuvar Analizlerinin Gerçekleştirilmesi 37
3.2.3. Yarış Performansına İlişkin Verilerin İşlenmesi 37
3.2.4. İstatistiksel Analizler 38
4. BULGULAR 40
4.1. Örneklem Özellikleri 40
4.2. Yarış Performansı Değişkenine Ait Bulgular 42
4.2.1. İngiliz ve Arap Atlarında Yarış Performansı Değişkenine Ait Bulgular ……………………………………………………………………………...44
4.2.2. Dişi ve Erkek Atlarda Yarış Performansı Değişkenine Ait Bulgular 47
4.3. Miyostatin Değişkenine Ait Bulgular 51
4.3.1. İngiliz ve Arap Atlarında Miyostatin Değişkenine Ait Bulgular 52
4.3.2. Dişi ve Erkek Atlarda Miyostatin Değişkenine Ait Bulgular 55
4.4. İrisin Değişkenine Ait Bulgular 58
4.4.1. İngiliz ve Arap Atlarında İrisin Değişkenine Ait Bulgular 61
4.4.2. Dişi ve Erkek Atlarda İrisin Değişkenine Ait Bulgular 63
4.5. Eritropoetin Değişkenine Ait Bulgular 67
4.5.1. İngiliz ve Arap Atlarında Eritropoetin Değişkenine Ait Bulgular 68
4.5.2. Dişi ve Erkek Atlarda Eritropoetin Değişkenine Ait Bulgular 71
5. TARTIŞMA 75
5.1. Yarış Performansı 76
5.2. Miyostatin 82
5.3. İrisin 86
5.4. Eritropoetin 90
6. SONUÇ VE ÖNERİLER 93
7. KAYNAKLAR 95
8. EKLER 112
10. ÖZGEÇMİŞ 114
Investigation of extreme precipitation indices in Turkey
No full text© 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.This paper focuses on spatiotemporal characteristics of precipitation indices of Turkey’s precipitation data for the periods 1966–2014. Seven precipitation indices include the number of extremely wet days, very wet days, heavy precipitation days (10 mm and 20 mm), simple daily intensity days, and consecutive dry and wet days. The indices are based on homogenized precipitation data. Besides, long-term changes and trends in the time series of precipitation indices in terms of climatic variability were investigated using nonparametric time series analysis methods. The results obtained are summarized as follows. Extremely wet and very wet day indices include significant decreasing trends in most stations. The trend is statistically significant at some stations in the Mediterranean region and southeastern Anatolia region. The number of heavy precipitation day indices tend to decrease in most of the stations in the Mediterranean precipitation zone, throughout Turkey. Simple daily intensity index generally displays an increasing trend. Consecutive dry days include an overall upward trend throughout Turkey. The inner and in the west of southeastern Anatolia regions have displayed a statistically significant increasing trend. Consecutive humid days tend to decrease overall outside of Turkey’s internal parts. The study also examined the relationships between atmospheric oscillation indices and precipitation indices. Accordingly, the atmospheric oscillation index that has the most decisive effect on the Turkish precipitation indices is NAO
Mehmed Münib Ayıntabi ve el-Makametü'l-Viladiyye ve'l-Makaletü'l-Miladiyye adlı eserinin tahkik ve tahlili
No full textMEHMED MÜNÎB AYINTÂBÎ VE EL-MAKÂMETÜ’L-VİLÂDİYYE VE’L-MAKÂLETÜ’L-MÎLÂDİYYE ADLI ESERİNİN TAHKİK VE TAHLİLİBu çalışmada XVIII. yüzyılın son yarısı ile XIX. yüzyılın ilk çeyreğine tekabül eden zaman diliminde yaşamış olan Osmanlı müelliflerinden Mehmed Münîb Ayıntâbî (ö.1238/ 1823) ve onun “el-Makâmetü’l-Vilâdiyye ve’l-Makâletü’l-Mîlâdiyye” isimli eseri konu edilmiştir. Üç bölümden oluşan çalışmanın ilk bölümünde Ayıntâbî’nin hayatı ve eserleri yaşadığı dönem bağlamında incelenmiştir. İkinci bölümde “el-Makâmetü’l-Vilâdiyye”nin tahlili yapılmış; bu tahlile basamak olması için öncelikle Arap edebiyatında makâme türünün tarihçesi ve genel özellikleri incelenmiş, sonrasında söz konusu eser; nüshalarının vasıfları, telif sebebi, konusu, kaynakları, muhtevası, üslubu ve kullanılan edebî sanatlar açısından ayrıntılı bir şekilde ele alınmıştır. Üçüncü bölümde ise eserin tahkikine (edisyon kritik) yer verilmiştir. Bu çalışmayla Osmanlı döneminde üretilen eserlerden biri gün yüzüne çıkartılarak, dönemin doğru anlaşılmasına hizmet etmek ve Arap edebiyatı Osmanlı dönemi literatürüne mütevazı bir katkıda bulunmak hedeflenmiştir.MEHMED MÜNĪB AYINTᾹBĪ AND THE CRITICAL EDITION AND ANALYSIS OF HIS WORK TITLED AS AL-MAQᾹMAH AL-VİLᾹDİYYAH WAL-MAQᾹLAH AL-MĪLᾹDİYYAHIn this study the Ottoman author Mehmed Münīb Ayıntābī (time of death 1238/ 1823) who lived in the period that corresponds to the final half of the XVIII. century and the first quarter of the XIX. century and his work titled as “al-Maqāmah al-Vilādiyyah wal-Maqālah al-Milādiyyah” is entreated. In the first part of the study, which is comprised of three parts, the life and works of Ayıntābī is examined in the context of the period that he lived. In the second part, “Al-Maqāmah Al-Viladiyyah” is analyzed; in order to be a stage to this analysis, firstly the history and the general characteristics of the maqamah genre in the Arabic literature are examined and then the aforesaid work is covered in detail in terms of the features of the manuscripts, reason of the writing, subject, sources, content, style and literary arts used. In the third part, the work is examined (critical edition). With this work, one of the works produced in the Ottoman period was brought to the surface to serve the correct understanding of the period and to make a modest contribution to the Ottoman period of the Arabic literature
Effects of age and sex on some body measurements and body weight in Malya sheep
No full textcilek, suleyman/0000-0002-2352-649XThis experimental research was carried out to determinate effects of age and sex on body weight and some body measurements of Malya sheep (11/16 Akkaraman x 5/16 Deutsches Merinofleischschaf). Body measurements, wither height, rump height, back height, rump length, rump width, front cannon bone circumference, body length, chest circumference, chest depth, chest length, chest width, tail length, tail-tarsal joint distance, and tail width were recorded. This is the first study on body measurements of Malya breed sheep and rams. General linear model was used in Minitab program to investigate effects of age and sex on these traits. Duncan multiple range test was used for multiple comparisons in important subgroups. The least square means of body weight of male and female at 1-year-old, 2-year-old, 3-year-old, 4-year-old and 5 years and older were estimated. Effect of age and sex on all body measurements were significant except for effect of age on back height.Scientific Research Project Coordination Unit of Kirikkale UniversityKirikkale University [2012/42]This research was supported by the Scientific Research Project Coordination Unit of Kirikkale University (project number 2012/42). The author is grateful to assistance from Scientific Research Project Coordination Unit of Kirikkale University and Mehmet Gevrek, Turan Kaya, Kadir Gokhan Yildirim, his mother Zahide cilek and his father Ali cilek
Psoriatic fasciitis in a pediatric patient: A case report
No full textBACKGROUND Diffuse fasciitis with psoriatic arthritis on magnetic resonance imaging (MRI) has not been previously described in childhood. Here we present the first case report of a pediatric patient developing fasciitis, beyond plantar fasciitis, with psoriatic arthritis. CASE SUMMARY An 11-year-old female was admitted with the complaints of psoriatic rash on the body associated with severe pain in the lower extremities and arthritis in the right knee. Psoriasis was confirmed by skin biopsy, she diagnosed with juvenile psoriatic arthritis. Diagnostic tests did not indicate any pathology except MRI. MRI of the femur and tibia revealed that high-signal inflammatory changes in the subdermal fascia. These findings led to a diagnosis of psoriatic fasciitis. Methotrexate was given for 3 mo but the patient showed no response to therapy; therefore, etanercept was added. However, there was no response to treatment. Etanercept was switched to adalimumab at the sixth month of therapy. Clinical improvement started with therapy of adalimumab within one month. Fasciitis finding in MRI disappeared at seventh months on adalimumab therapy. She has no complaint for two years with adalimumab. CONCLUSION The most effective imaging method is MRI and adalimumab may be the best choice of treatment for psoriatic fasciitis. © The Author(s) 2019
Determination of fleece qualities of malya sheep (11/16 Akkaraman X 5/16 Deutsches Merinofleischschaf) and effect of age and sex on these qualities
No full textcilek, suleyman/0000-0002-2352-649XThis study was carried out to investigate fleece qualities of Malya ewes and rams and effect of age (14 months age, 26 months age, 38 months age, 50 months age and 62 months age and older) and sex (ewe and ram) on fleece traits. The data were collected from 100 head ewes and 50 head rams raised at Malya State farm and were analyzed by using least squares method. The least squares means was calculated for greasy fleece weight (2.90 +/- 0.08 kg), clean wool percentage (50.05 +/- 0.69%), tenacity (18.72 +/- 0.52 Cn/Tex), fiber elasticity (31.17 +/- 0.43%), fiber diameter (26.66 +/- 0.19 mu m), staple length (H) (31.88 +/- 0.46 mm), and staple length (B) (47.67 +/- 0.72 mm), medullated fiber rate (23.52 +/- 0.73%), comfort factor (78.04 +/- 1.14%), and opacity (75.67 +/- 0.11%). Effect of age on all fleece traits was significant (P<0.001-P<0.05) except for fiber elasticity. Effect of sex on all fleece traits was significant (P<0.001-P<0.05) except for fiber diameter, tenacity and comfort factor. It can be generally concluded that younger and rams have higher fleece yield and fleece quality than older and ewes and fleece quality of Malya sheep was between textile and carpet industry and is closely similar to textile type wool.Scientific Research Project Coordination Unit of Kirikkale UniversityKirikkale University [2011/38]This research was supported by the Scientific Research Project Coordination Unit of Kirikkale University (project number 2011/38). The author is grateful to Scientific Research Project Coordination Unit of Kirikkale University and housekeeper Mehmet Gevrek, Veterinary Medicine Alim Zeber, his mother Zahide Cilek, and his father Ali Cilek
Hydrophobic coating of surfaces by plasma polymerization in an RF plasma reactor with an outer planar electrode: synthesis, characterization and biocompatibility
No full textThis paper presents the plasma polymerization of poly(hexafluorobutyl acrylate) (PHFBA) thin films on different substrates in an RF plasma reactor with an outer planar electrode. This reactor configuration allows. large area uniformity and fast processing times. Deposition rates of up to 60 nm min(-1) were observed. The influence. of plasma power and substrate temperature on the. deposition rate, structure and wettability of the as-deposited films was. investigated. It was observed that better hydrophobicity was obtained at high plasma power and in low temperature conditions. PHFBA thin films deposited on electrospun poly(acrylonitrile) fiber mats under such conditions resulted in superhydrophobic surfaces with. contact angle values greater than 150 degrees. In. vitro cell studies using human epithelial cells demonstrated the non-toxic nature of the. plasma-polymerized PHFBA films.Scientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [213M399]; TUBITAK-BIDEBTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK)This project was supported by the Scientific and Technological Research Council of Turkey (TUBITAK) with grant number 213M399. The author MG was supported by TUBITAK-BIDEB
Impact of Biotic and Abiotic Stresses on Onion Production: Potential Mitigation Approaches in Modern Era
No full textOnion is one of the most commonly consumed vegetable crops in the world, following tomato. Biotic and abiotic stresses are known to affect onion production, causing significant yield losses, similar to other vegetables and main crops. It is estimated that about 40% of overall losses in agricultural production is related to insects, pests, and weeds. Likewise, environmental fluctuation and climate change are threatening the production rate of onion. Strangely, in the era of omics approach to understand plants’ responses to environmental changes, there is limited literature regarding onion response to biotic and abiotic stresses. This chapter enlightens the impacts of biotic and abiotic stresses with the potential exploitation of modern plant improvement techniques. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2023
Careers and Research Performance of PhD Program Graduates of Health Sciences in Turkey
No full textIn this review, we aimed to evaluate PhD graduates of the period between 1985-2010 and analyze the status, motivation and positive and negative factors influencing research motivation of graduates in eight disciplines from three graduate schools of Health Sciences in Turkey and to compare with the present status in the world. Some information obtained by web-based survey is the following: The most of graduates (83%) have academic positions in basic sciences departments in the faculty of medicine in universities. 94.2 % of graduates recognized the importance of personal motivation, while 54% of them thought that finding the appropriate research environment was important for research. For 52%, the biggest hindrance to medical research was lack of funding and for 39%, lack of technic personnel for research. The studies in the literature related to PhD graduates pointed out to the following facts: The number of PhD graduates is increasing gradually and the graduates' career choices have changed from academic to non-academic positions, especially in the industry. This is not parallel to our pilot study findings. About the teaching perspective treated in the relevant literature, the concept of "one should be a good researcher, as well as a good teacher" is dominant. PhD graduates in our pilot study mentioned that they had responsibilities in the education activities during their PhD education. We think that these responsibilities are useful for their future academic career. In conclusion, the majority (83%) of graduates from Graduate Schools of Health Sciences in Turkey are enrolled into academic researcher positions in universities. They keep producing funded research work as a first author and publish despite some problems
