102,694 research outputs found
Selected materials from the international conference "Is there a Court for Gaza?", 22 May 2009, Lelio Basso International Foundation, Rome
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Haemoglobin targets: we were wrong, time to move on
No full textBACKGROUND: The current 3rd edition of the Italian Society of Nephrology guidelines has been drawn up to summarize evidence of key intervention issues on the basis of systematic reviews (SR) of randomized trials (RCT) or RCT data only. In the present guideline, evidence of optimal haemoglobin (Hb) target levels in chronic kidney disease (CKD), either for pre-dialysis, dialysis or renal transplanted patients, is presented.
METHODS: SR of RCT and RCT on different Hb target levels in patients with CKD were identified, referring to a Cochrane Library and Renal Health Library search (2005 update). Quality of SR and RCT was assessed according to current methodological standards.
RESULTS: Four SR (19 RCT) were found addressing the point. Methodological quality of available trials was suboptimal. In CKD patients (non-dialysis patients) Hb targets of 11.3 g/dL should be preferred to Hb >13.5 g/dL (evidence from RCT). A Hb target of 11.0-11.5 g/dL should be preferred in CKD patients receiving dialysis treatment without significant cardiac disease, since no survival benefits has been showed with Hb >14 g/dL (evidence from RCT). The optimal Hb target in haemodialysis patients with severe cardiac disease should be 10.0-10.5 g/dL (evidence from SR). Increases in Hb target lev-els are associated with improved quality of life, although this was mainly noticed in observational studies and in few RCT often relying on unvalidated quality of life assessment scales.
CONCLUSION: In CKD patients current available evidence supports the hypothesis that optimal Hb targets should be low to subnormal
Exploiting Self-Absorption for Plasma Characterization in Laser-Induced Breakdown Spectroscopy Experiments: A Comparison of Two Recent Approaches
No full textIn this article, we compare two analytical methods that have been recently proposed: the columnar density Saha-Boltzmann plot method of Cristoforetti and Tognoni (Cristoforetti, G.; Tognoni, E. Spectrochim. Acta, Part B, 2013, 79-80, 63-71) and the C-sigma model of Aragon and Aguilera (Aragon, C.; Aguilera, J. A. J. Quant. Spectrosc. Radiat. Trans. 2014, 149, 90-102). Both methods are based on the exploitation of self-absorbed lines for the characterization of plasmas in laser-induced breakdown spectroscopy experiments. However, although the two methods can be safely applied in many cases, their usefulness is limited in many practical cases of interest because of the intrinsic constraints of the used plasma model or because of the complexity of the numerical treatment. The two methods are presented here and critically discussed. Finally, an extended C-sigma approach is proposed to merge the advantages of the two methods, overcoming their intrinsic limitations and simplifying the numerical treatment
Is there a Court for Gaza? : A test bench for International Justice
No full textThe 'Goldstone Report' of September 2009 started a critical debate at the international level. The Report raised serious allegations of grave violations of international law with regard to the Israeli attack on Gaza of 27 December 2008 - 18 January 2009, amounting to possible war crimes and crimes against humanity. The UN General Assembly and the Human Rights Council, amidst high political pressure, endorsed the Report’s recommendations, calling for prompt and proper investigations to ensure accountability and justice for the victims. Given the lack of proper investigations at the national level, international justice mechanisms are now needed. Indeed, the ICC opened a preliminary examination of the situation but difficulties arose because of the uncertain status of the occupied Palestinian territory. The issue of the existence of a State of Palestine is extremely actual and still unsolved at the UN level
Formarsi all’obbedienza o all’autonomia? e come? [Education to autonomy or obedience? And how?]
No full textThe nurses' autonomy should be pursued and practiced at several levels: not only in practice but also in the way the knowledge is updated. Most of the initiatives and teaching-learning methods offered in basic and continuing education are more oriented to contents and techniques that to the development of a critical approach. A nursing approach should be oriented at focusing on the impact of interventions and techniques on patients problems and needs
L'esperienza di una rete di studio multicentrica sull'assistenza diabetologica nel Triveneto.
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