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More on: factor V Leiden and prothrombin G20210A polymorphisms as risk factors for miscarriage during a first-intended pregnancy: the matched case-control 'NOHA first' study.
No full text.More on: factor V Leiden and prothrombin G20210A polymorphisms as risk factors for miscarriage during a first-intended pregnancy: the matched case-control 'NOHA first' study. J Thromb Haemost. 2006; 4(3):709-10
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Anticoagulant prophylaxis in women affected by thrombophilia and previous obstetric complications.
No full text24 h and prolonged ambulatory ECG recording in patients with ventricular ectopy: Maybe 24 h are not enough?
No full textImpact of common thrombophilias and JAK2 V617F on pregnancy outcomes in unselected Italian women.
No full textBACKGROUND:
Although an association between thrombophilias and adverse pregnancy outcome has been shown, the influence of the most common inherited thrombophilias and the somatic mutation JAK2 V617F in determining an adverse outcome is questioned.
OBJECTIVES:
We examined the contribution of the factor V Leiden (FVL), the prothrombin G20210A (PTm) and the somatic JAK2 V617F mutations to adverse pregnancy outcome in an unselected cohort of pregnant women.
PATIENTS/METHODS:
During the study period, 5345 pregnant women were admitted to the 14 hospitals of the five provinces of the Campania region (Italy). Of these, 3097 samples were investigated and obstetric history collected. The presence of the FVL, PTm, and JAK2 V617F mutation was prospectively determined by polymerase chain reaction followed by TaqMan SNP genotyping assays.
RESULTS AND CONCLUSIONS:
We identified 119 (3.8%) women that carried FVL and 138 (4.4%) with the PTm. Only 4 (0.1%) women carried both mutations. Only one woman tested positive for the JAK2 V617F somatic mutation. The prevalence of a previous history of an adverse pregnancy outcome was similar in women with common thrombophilias as compared to those without. In the current pregnancy, there was no association of any of the genetic markers considered with any of the adverse outcomes investigated. Carriership of FVL or PTm showed a positive trend with delivery of a small for gestational age newborn (OR: 1.5, 95% CI: 0.9-2.5). Pregnancy outcomes in asymptomatic women with inherited thrombophilias are often uneventful. Therefore, in women at low-risk of an adverse pregnancy, neither screening for common thrombophilias nor administration of routine thromboprophylaxis are warranted
The haplotype M2 within the ANXA5 gene is independently associated with the occurrence of deep venous thrombosis.
No full textPredictive value of symptoms in subjects with palpitations and normal ECG undergoing event-recorder monitoring
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