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Mycophenolate mofetil inhibits lymphocyte binding and the upregulation of adhesion molecules in acute rejection of rat kidney allografts.
No full textMycophenolate mofetil (MMF) interacts with purine metabolism and possibly with the expression of adhesion molecules. In the present study, we analysed the expression of these molecules in transplanted kidney allografts treated with RS LBNF1 kidneys were orthotopically transplanted into Lewis rats and either treated with RS (20 mg/kg/day) or vehicle. Rats were harvested 3, 5 and 7 days following transplantation. For binding studies, fresh-frozen sections of transplanted kidneys were incubated with lymph node lymphocytes (LNL) derived from transplanted rats. Additionally, immunohistology was performed with various monoclonal antibodies. In general, MMF resulted in better preservation of graft structure by 7 days. Cellular infiltration and tubular atrophy were less pronounced. At day 3, macrophages were diminished in MMF-treated animals to a high extent, while the number of T cells was almost identical to that of controls. In addition, the number of cells positive for MHC class II and LFA-1 was reduced in the MMF-treated animals. These findings correlated with the binding results. Three days following engraftment, LNL bound to MMF-treated kidneys to a lesser extent compared to controls. In conclusion, MMF resulted in a markedly reduced leucocytic infiltrate, presumably based on a reduced expression of lymphocytic adhesion molecules and an interaction with macrophages
AGONISTIC AND ANTAGONISTIC INTERACTIONS OF ANTI-INTERLEUKIN-2 RECEPTOR MONOCLONAL-ANTIBODIES IN RAT RECIPIENTS OF CARDIAC ALLOGRAFTS
No full textCYCLOSPORINE AND ANTI-INTERLEUKIN-2 RECEPTOR MONOCLONAL-ANTIBODY THERAPY SUPPRESS ACCELERATED REJECTION OF RAT CARDIAC ALLOGRAFTS THROUGH DIFFERENT EFFECTOR MECHANISMS
No full textSOME PARAMETERS AFFECTING EFFICACY OF ANTI INTERLEUKIN-2 RECEPTOR MONOCLONAL ANTIBODY (IL-2R mAb) THERAPY IN RAT RECIPIENTS OF CARDIAC ALLOGRAFTS
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BIODISTRIBUTION OF ANTI-INTERLEUKIN-2 RECEPTOR MONOCLONAL-ANTIBODIES CORRELATES WITH THEIR THERAPEUTIC EFFICACY FOLLOWING TRANSPLANTATION
No full textSYNERGY BETWEEN SUBTHERAPEUTIC DOSES OF CYCLOSPORINE AND IMMUNOLOGICAL ENHANCEMENT IN RAT RECIPIENTS OF CARDIAC ALLOGRAFTS
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2 PHENOTYPICALLY DISTINCT POPULATIONS OF T-CELLS HAVE SUPPRESSOR CAPABILITIES SIMULTANEOUSLY IN THE MAINTENANCE PHASE OF IMMUNOLOGICAL ENHANCEMENT
No full textIMMUNOHISTOLOGIC PROFILE OF CELLS INFILTRATING ACUTELY REJECTING AND LONG-SURVIVING RAT CARDIAC ALLOGRAFTS
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