1,720,971 research outputs found
KatG 315 mutation as a molecular determinant for isoniazid resistance in mycobacterium tuberculosis
No full textEmergence of multidrug resistant tuberculosis
(MDR-TB) and extensively drug resistant
tuberculosis (XDR-TB) is one of the reasons
why tuberculosis (TB) continues to cause great
mortality and morbidity in less-developed
countries. The development of rapid diagnostic
methods targeting genetic mutations associated
with resistance to the anti-tuberculous drugs is
essential to fight this deadly pathogen. Isoniazid
(INH) has been included in the multidrug
regimens for the treatment of drug-susceptible
TB for the decades. In the worldwide setting,
isoniazid resistance was highly prevalent and was
observed in one of every seven TB cases. Since
katG315 mutation is highly prevalent, the common
mutation in the enzyme essential for the activation
of the INH concerned with the mechanism of drug
resistance and associated with high level resistance
to INH, katG315 mutation was necessary to be
identified by molecular method as a molecular
determinant of INH resistant Mycobacterium
tuberculosis. The prevalence of katG315 mutation
in various countries was discussed in this report
and a new molecular method for the detection of
the mutation was proposed
Atypical El Tor: new vibrio cholerae O1 biotype causing epidemic cholera
No full textToxigenic strains of Vibrio cholerae serogroup O1 and O139 are causative agents of deadly
diarrheal disease named cholera. Vibrio cholerae O1 is traditionally divided into two
biotypes, classical and El Tor, which are different in phenotypic as well as genotypic traits.
Since 1961, classical strains of Vibrio cholerae O1 serogroup has become obsolete as the
cause of epidemic and pandemic cholera and replaced by El Tor strains. Since 2002, atypical
O1 El Tor strains possessing the traits of classical strains have been increasingly recognized
as the cause of cholera in many countries across the world. This article focuses on the genetic
traits of O1 classical and El Tor strains. Furthermore, an overview of emergence of atypical
O1 El Tor strains and their genetic traits is presented
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Unsupervised Skeleton Based Human Action Recognition
Full text link埼玉大学博士(工学)指導教員 : 小室 孝 教授textapplication/pd
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Unsupervised Skeleton Based Human Action Recognition
Full text link学位記番号 : 博理工甲第1366号博士の専攻分野の名称 : 博士（工学）
学位授与年月日 : 令和7年3月25日textapplication/pd
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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