139,250 research outputs found
ROLE OF ETHANOL-INDUCIBLE CYTOCHROME-P450 (P450IIE1) IN CATALYZING THE FREE-RADICAL ACTIVATION OF ALIPHATIC-ALCOHOLS
No full textROLE OF ETHANOL-INDUCIBLE CYTOCHROME-P450 (P450IIE1) IN CATALYZING THE FREE-RADICAL ACTIVATION OF ALIPHATIC-ALCOHOLS
No full textIncubation of rat liver microsomes with 1-propanol and 1-butanol in the presence of NADPH and of the spin trapping agent 4-pyridyl-1-oxide-t-butyl nitrone (4-POBN) allowed the detection of free radical intermediates tentatively identified as 1-hydroxpropyl and 1-hydroxybutyl radical, respectively. Microsomes isolated from rats treated chronically with ethanol (EtOH) or with the combination of starvation and acetone treatment (SA), exhibited a two-fold increase in the ESR signal intensity as compared to untreated controls, whereas no increase was observed in phenobarbital-induced (PB) microsomes. Consistently, in reconstituted membrane vesicles, ethanol-inducible cytochrome P450IIE1 was twice as active as phenobarbital-inducible P450IIB1 in producing 1-butanol free radicals. In the microsomal preparations from EtOH and SA pretreated rats the addition of antibodies against cytochrome P450IIE1, but not of preimmune IgGs, lowered the ESR signal of 1-butanol radicals by more than 50%. The same antibodies decreased the free radical production by untreated microsomes by 35-40%, but were ineffective on microsomes from PB-treated animals. This indicated that cytochrome P450IIE1 is the major enzyme responsible for the free radical activation of alcohols in control and ethanol-fed rats. The generation of 1-hydroxybutyl radicals by EtOH microsomes was inhibited by 40, 48 and 68%, respectively, by the addition of isoniazid, tryptamine and octylamine, compounds known to specifically affect the NADPH oxidase activity of this isoenzyme. This effect was not due to the scavenging of the alcohol radical since none of these compounds affected the ESR signals originated from 1-butanol in a xanthine-xanthine oxidase system. When added to reconstituted membrane vesicles isoniazid, tryptamine and octylamine also decreased 1-butanol radical formation by P450IIE1 by 54, 38 and 66%, respectively. Such an inhibition corresponded to the effect exerted by the same compounds on O2- release from P450IIE1 containing vesicles. These results indicate that the capacity of cytochrome P450IIE1 to reduce oxygen is related to its ability to generate alcohol free radicals and suggest that ferric cytochrome P450-oxygen complex might act as oxidizing species toward alcohols
Spatially-localized time dependent solutions including turbulence and their interactions in 2D Kolmogorov flow
No full textIn 2D Kolmogorov flow in small aspect ratio domains, spatially-localized solutions such as kink, traveling or time-dependent kink-antikink pars coexist. However, the conservation of the flow rate in the y direction strongly restrict combination of localized solutions and their positioning. We find that by adding a homogeneous flow U y their positioning is controlled and each of localized solutions including a spatially-localized chaos is isolated. Numerical results suggest that these isolated solutions can be elements constructing a whole flow
Characteristics of overlap region in high-Reynolds number turbulent channel flow
No full textDirect numerical simulation of the fully developed turbulent channel flows have been carried out at the Reynolds number based on the friction velocity and the channel half width, 2000, 4000 and 8000. A hybrid 10th order accurate finite difference scheme in the stream and spanwise directions, and a second-order scheme in the wall-normal direction is adapted as the spatial discretization method. We observed the plateau profiles in the indicator function corresponded to the von Karman constant. Furthermore, second peak of streamwise pre-multiplied spectra were appeared in the same wall normal height, 300 < y+ < 600, in case of Re = 4000. Nevertheless, the effects of the lager than the channel half height scale on the streamwise turbulent intensity are fixed contributions without dependence on Reynolds number. These results suggested that the new streamwise vortexes are formed between buffer layer and outer layer with increasing of Reynolds number
La 'circunstancia' de 'Herederos y Pretendientes
No full textIn June 2010, the Ortega y Gasset Foundation hosted a Conference about the “Spanish Philosophical Transition” in order to debate the book of Francisco Vázquez, La filosofía española. Herederos y Pretendientes. Una lectura sociológica (1963-1990), recently published. This paper is the author’s response to criticism raised in the Conference and to published reviews received by this book. First, the author summarized the argument of Herederos y pretendientes. Secondly he responds and takes into account the most important objections against the book’s hypothesis and methodology. Finally the author evaluates the favorable judgments received by the book and suggests the limits of the historian’s task.Fundación Ortega y Gasset-Marañó
Author self-citation in orthodontics is associated with author origin and gender.
No full textBACKGROUND
The aims of this bibliometric study were to determine author self-citation trends in high-impact orthodontic literature and to investigate possible association between self-citation and publication characteristics.
METHODS
Six orthodontic journals with the highest impact factor as ranked by 2017 Journal Citation Reports were screened for a full publication year (2018) for original research articles, reviews, and case reports. Eligible articles were scrutinized for article and author characteristics and citation metrics. Univariable and multivariable negative binomial regression was used to examine associations between self-citation incidence and publication characteristics.
RESULTS
Medians for author self-citation rate of the most self-citing authors and self-citations were 3.03% (range 0-50) and 1 (range 0-19), respectively. In the univariable analysis, there was no association between self-citation counts and study type (P = 0.41), article topic (P = 0.61), number of authors (P = 0.62), and rank of authors (P = 0.56). Author origin (P = 0.001), gender (P = 0.001) and journal (P = 0.05) were associated with self-citation counts and in the multivariable analysis only origin and gender remained strong self-citation predictors. Asian authors and females self-cited significantly less often than all other regions and male authors.
CONCLUSIONS
Authors in orthodontics do not self-cite at a frequency that suggests potential citation manipulation. Author origin and gender were the only variables associated with citations counts. More bibliometric research is necessary to draw solid conclusions about author self-citation trends in orthodontic literature
Overview of the Author Profiling Task at PAN 2013
No full text[EN] This overview presents the framework and results for the Author Profiling
task at PAN 2013. We describe in detail the corpus and its characteristics,
and the evaluation framework we used to measure the participants performance to
solve the problem of identifying age and gender from anonymous texts. Finally,
the approaches of the 21 participants and their results are described.The author profiling task @PAN-2013 was an activity of the WIQ-EI IRSES project (Grant No. 269180) within the FP 7 Marie Curie People Framework of the European Commission. We want to thank the Forensic Lab of the Universitat Pompeu Fabra Barcelona for sponsoring the award for the winner team. The work of the first author was partially funded by Autoritas Consulting SA and by Ministerio de Economía y Competitividad de España under grant ECOPORTUNITY IPT-2012-1220-430000. The work of the second author was in the framework the DIANA-APPLICATIONS-Finding Hidden Knowledge in Texts: Applications (TIN2012-38603-C02-01) project, and the VLC/CAMPUS Microcluster on Multimodal Interaction in Intelligent Systems. The work of fifth author was funded in part by the Swiss National Science Foundation (SNF) project "Mining Conversational Content for Topic Modelling and Author Identification (ChatMiner)" under grant number 200021_130208.Rangel, F.; Rosso, P.; Koppel, M.; Stamatatos, E.; Inches, G. (2013). Overview of the Author Profiling Task at PAN 2013. CLEF Conference on Multilingual and Multimodal Information Access Evaluation. 352-365. https://riunet.upv.es/handle/10251/46636S35236
Author Co-Citation Analysis (ACA): a powerful tool for representing implicit knowledge of scholar knowledge workers
No full textIn the last decade, knowledge has emerged as one of the most important and valuable organizational assets. Gradually this importance caused to emergence of new discipline entitled ―knowledge management‖. However one of the major challenges of knowledge management is conversion implicit or tacit knowledge to explicit knowledge. Thus Making knowledge visible so that it can be better accessed, discussed, valued or generally managed is a long-standing objective in knowledge management. Accordingly in this paper author co- citation analysis (ACA) will be proposed as an efficient technique of knowledge visualization in academia (Scholar knowledge workers)
Semana Santa y su simbología. 5 Segunda época Año 3 (2019) enero-junio. Rutas de Campo. Trabajo de Campo: Iztapalapa: memoria y cultura
No full textLos dos grandes momentos en torno a los cuales gira la cosmovisión católica, el nacimiento de Jesús y su muerte, han dado lugar, el primero, a la celebración de la Navidad, y el segundo, a la conmemoración de Semana Santa. En este texto nos ocuparemos de los años finales de la vida de Jesús, pues es precisamente Semana Santa la celebración litúrgica con que se recuerda su Pasión y su muerte. Recordemos que, en este contexto, el término “pasión” hace referencia al sufrimiento y a la serie de tormentos a que fue sometido Jesús poco antes de su muerte en la cruz, que todos conocemos.Altamirano, Ignacio Manuel (1974). Paisajes y leyendas. Tradiciones y costumbres de México. México: Porrúa.Calendario de fiestas tradicionales (1988). México: Dirección General de Culturas Populares-SEP.Calendario Litúrgico Pastoral 1991 (1990). México: Obra Nacional de la Buena Prensa.Campos, Rubén M. (1929). El folklore literario en México. Investigación de la producción literaria popular. México: Talleres Gráficos de la Nación._____ (1958). “Semana Santa”. En Fiesta. México: Talleres de la Secretaría de Hacienda.Castelló Iturbide, María Teresa (1958). “El altar del Viernes de Dolores”. En Fiesta. México: Talleres de la Secretaría de Hacienda.Catalán Blanco, Juan Carlos (s.f.). “Las fiestas de carnestolendas y la celebración de la Semana Santa en la época colonial” [inédito]. s.l.: Dirección General de Culturas Populares de Guerrero-SEP.Cid, Carlos, y Manuel Riu (1965). Historia de las religiones. Barcelona: Sopena._____ (1987). Compendio de historia sagrada y de la historia de la Iglesia. México: Progreso.Crumrine N., Roos (1979). “Cuaresma”. En Gran Enciclopedia Rialp. Madrid: Rialp.Estrada, Genaro (1945). Visionario de la Nueva España. México: Patria.Estrada, Humberto (1985). “La cuaresma” [inédito]. s.l.: Dirección General de Culturas Populares-SEP.Foster, George M. (1962). Cultura y conquista. Xalapa: Universidad Veracruzana.García Cubas, Antonio (1945). El libro de mis recuerdos. México: Patria.González Obregón, Luis (1936). Croniquillas de la Nueva España. México: Botas.____(1941). Las calles de México. México: Botas.Horcasitas, Fernando (1974). El teatro náhuatl: época novohispana y moderna. México: IIH-UNAM.Iglesias y Cabrera, Sonia C. (1996). Tradiciones de Cuaresma y Semana Santa. México: Museo Nacional de Culturas Populares-Dirección General de Culturas Populares._____ (2001). La semana Santa en México. Con la muerte en la cruz. México: Dirección General de Culturas Populares.Lercaro, Giacomo (1960). ¿Cuál es el vocabulario de la liturgia católica? México: Novaro.Macgowan, Kenneth, y William Melnitz (1964). Las edades de oro del teatro. México: FCE.Mendieta, Gerónimo de (1945). Historia eclesiástica indiana. México: Salvador Sánchez.Mendoza, Vicente T., y Adalberto Fuentes Cruz (1945). “Drama de la Pasión intitulado: el drama del Gólgota, que se representa en la delegación de Milpa Alta, D.F.”. Anuario de la Sociedad Folklórica de México, 6.Moreno Toscano, Alejandra (1981). “La conquista espiritual”. En Historia general de México. México: El Colegio de México.Olavarría Ferrari, Enrique de (1953). “Pasión de Cristo”. En Enciclopedia de la religión católica [t. V]. Barcelona: Dalma y Jovier._____ (1961). Reseña del teatro en México. México: Porrúa.Pike E., Royston (1986). Diccionario de religiones. México: FCE.Prieto, Guillermo (1969). Memorias de mis tiempos. México: Patria.Rodríguez, Mariángela (1991). Hacia la estrella con la Pasión y la ciudad a cuestas. Semana Santa en Iztapalapa. México: Ediciones de la Casa Chata-CIESAS.Sociedad Bíblica Británica y Extranjera de Londres (1929). La Santa Biblia. Londres: SBBEL.Vetancurt, Agustín de (1941). Teatro mexicano: descripción breve de los sucesos exemplares de la Nueva España en el mundo occidental de las Indias. Madrid: J. Porrúa.Verti, Sebastián (1991). Tradiciones mexicanas. México: Diana.Weckmann, Luis (1984). La herencia medieval de México. México: FCE
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